中药外敷联合二仙汤治疗桥本氏甲状腺炎伴结节患者的疗效<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2026.06.003

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摘要 【目的】探讨中药外敷联合二仙汤治疗桥本氏甲状腺炎(HT)伴结节(痰结血瘀证)患者的临床疗效。【方法】选择2022年6月至2024年12月上海市浦东新区浦兴社区卫生服务中心和上海中医药大学附属龙华医院收治的196例HT伴结节(痰结血瘀证)患者,随机分为对照组与观察组,每组98例。对照组患者单纯采用二仙汤治疗,观察组患者采用二仙汤联合中药外敷治疗。比较两组患者治疗前后的中医证候积分、甲状腺功能和抗体水平以及甲状腺结节最大直径。【结果】治疗前,两组各项观察指标比较,差异均无统计学意义(均P＞0.05)。治疗后,观察组中医证候各项积分均显著低于对照组(均P＜0.05);观察组甲状腺素(TSH)、游离甲状腺素(FT₄)水平显著高于对照组(均P＜0.05),观察组抗过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平显著低于对照组(均P＜0.05);两组甲状腺结节最大直径均较治疗前缩小,且观察组显著小于对照组(P<0.05)。【结论】二仙汤联合中药外敷治疗HT伴结节患者,可有效改善患者的中医证候症状,调节甲状腺功能,降低甲状腺相关抗体水平,并缩小甲状腺结节体积,临床疗效显著,值得临床推广应用。

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	吴天芯
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	杨燕青
	顾佳音
	张笑

关键词 ：桥本病, 甲状腺结节, 敷贴疗法, 中医药疗法

Abstract：【Objective】 To investigate the clinical efficacy of external application of traditional Chinese medicine combined with Erxian Decoction in the treatment of patients with Hashimoto's thyroiditis (HT) accompanied by nodules (phlegm stagnation and blood stasis syndrome). 【Methods】 A total of 196 patients with HT accompanied by nodules (phlegm stagnation and blood stasis syndrome) admitted from June 2022 to December 2024 were enrolled and randomly divided into a control group and an observation group, with 98 cases in each group. The control group was treated with Erxian Decoction alone, while the observation group received Erxian Decoction combined with external application of traditional Chinese medicine. The traditional Chinese medicine (TCM) syndrome scores, thyroid function, antibody levels, and the maximum transverse diameter of thyroid nodules were compared between the two groups before and after treatment. 【Results】 Before treatment, there were no statistically significant differences in all observed indicators between the two groups (all P>0.05). After treatment, the TCM syndrome scores in the observation group were significantly lower than those in the control group (all P<0.05). The levels of thyroid-stimulating hormone (TSH) and free thyroxine (FT₄) in the observation group were significantly higher than those in the control group (all P<0.05), while the levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were significantly lower than those in the control group (all P<0.05). The maximum transverse diameter of thyroid nodules in both groups decreased compared with before treatment, and the maximum transverse diameter in the observation group was significantly smaller than that in the control group (P<0.05). 【Conclusion】 The combination of Erxian Decoction and external application of traditional Chinese medicine can effectively improve TCM syndrome manifestations in patients with HT accompanied by nodules, regulate thyroid function, reduce thyroid-related antibody levels, and shrink thyroid nodules. The clinical efficacy is significant and worthy of further promotion in clinical practice.

Key words： Hashimoto Disease Thyroid Nodule Plastering therapy Traditional Chinese Medicine Therapy

收稿日期: 2025-11-24

中图分类号:

R736.1

基金资助:*上海市浦东新区卫生健康委员会优秀青年医学人才培养计划(编号:PWRq2022-38)

通讯作者: **E-mail:ssss1116ssss@163.com

引用本文:

吴天芯, 薛锦花, 杨燕青, 顾佳音, 张笑. 中药外敷联合二仙汤治疗桥本氏甲状腺炎伴结节患者的疗效^*[J]. 医学临床研究, 2026, 43(6): 889-892.
WU Tianxin, XUE Jinhua, YANG Yanqing, GU Jiayin, ZHANG Xiao. Effect of External Application of Traditional Chinese Medicine Combined with Erxian Decoction in the Treatment of Hashimoto's Thyroiditis with Nodules. JOURNAL OF CLINICAL RESEARCH, 2026, 43(6): 889-892.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.06.003 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I6/889

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