Abstract：【Objective】To evaluate the diagnostic value of multimodal ultrasound for benign and malignant thyroid nodules in patients with diffuse thyroid diseases. 【Methods】A total of 85 patients with diffuse thyroid diseases complicated with thyroid nodules treated in two hospitals from January 2021 to January 2023 were selected. Taking pathological results as the gold standard, all patients were divided into benign group (n=45) and malignant group (n=40). All patients underwent multimodal ultrasound examination. The nature, boundary, morphology, echo, aspect ratio, and calcification of thyroid nodules, as well as elastic parameters, blood flow typing, and hemodynamic parameters [peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI)] were compared between the two groups. Multivariate analysis was performed based on the ultrasonic characteristics of thyroid nodules in the two groups, and a nomogram model was constructed. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of multimodal ultrasound for benign and malignant thyroid nodules in patients with diffuse thyroid diseases. 【Results】Compared with the benign group, the malignant group had more solid nodules, blurred boundaries, irregular morphology, low or extremely low echo, larger aspect ratio, and obvious microcalcification. The proportions of blood flow types Ⅲ and Ⅳ in the malignant group were higher than those in the benign group, PSV and RI were higher than those in the benign group, and EDV was lower than that in the benign group, with statistically significant differences (all P<0.05). Multivariate analysis showed that the ultrasonic characteristics and blood flow parameters of thyroid nodules were significantly correlated with the benignancy and malignancy of thyroid nodules (P<0.05). The accuracy, sensitivity, and specificity of multimodal ultrasound combined examination in diagnosing benign and malignant thyroid nodules in patients with diffuse thyroid diseases were 95.3%, 95.0%, and 95.6%, respectively, with high diagnostic efficacy. 【Conclusion】 Multimodal ultrasound has high diagnostic value for benign and malignant thyroid nodules in patients with diffuse thyroid diseases.
许建春, 刘玲. 多模态超声对甲状腺弥漫性病变患者甲状腺结节良恶性的诊断价值[J]. 医学临床研究, 2025, 42(6): 970-973.
XU Jianchun, LIU Ling. Diagnostic Value of Multimodal Ultrasound for Benign and Malignant Thyroid Nodules in Patients with Diffuse Thyroid Diseases. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 970-973.
[1] 姜可伟,王晨一.甲状腺癌临床研究现状和热点[J].中华普通外科杂志,2021,36(6):401-404.
[2] 曾玲,黄玲,刘立江,等.超微血管成像联合高频超声对弥漫性甲状腺病背景下甲状腺结节良恶性的诊断价值[J].中国现代医学杂志,2022,32(22):32-37.
[3] 张娜,闫凤芝,李娅,等.多模态超声在甲状腺弥漫性病变背景中C-TIRADS 4a类结节诊断价值优势[J].中国超声医学杂志,2023,39(5):490-494.
[4] 中华医学会内分泌学分会,中华医学会外科学分会内分泌学组,中国抗癌协会头颈肿瘤专业委员会,等.甲状腺结节和分化型甲状腺癌诊治指南[J].中华核医学与分子影像杂志,2013,33(2):96-115.
[5] 中国超声医学工程学会浅表器官及外周血管专业委员会.甲状腺及相关颈部淋巴结超声若干临床常见问题专家共识(2018版)[J].中国超声医学杂志,2019,35(3):193-204.
[6] 吴立旋,傅继勇,马伟琼,等.超声结合BRAFV600E基因突变检测在桥本甲状腺炎合并甲状腺结节鉴别中的应用价值[J].中国现代医学杂志,2021,31(12):35-39.
[7] 张晓燕,张波,姜玉新,等.超声弹性成像评估桥本甲状腺炎背景下甲状腺结节的价值[J].中国医学科学院学报,2018,40(1):59-66.
[8] JIANG Q Y, LI J M, JING M R,et al. Cystathionine β-synthase regulates the proliferation, migration, and invasion of thyroid carcinoma cells[J].Oxid Med Cell Longev,2022, 2022:8678363.
[9] 刘明新,高莹,崔京淑,等.颈部Castleman病合并结节性甲状腺肿1例[J].临床与实验病理学杂志,2023,39(4):503-504.
[10] ALYAMI J, ALMUTAIRI F F, ALDOASSARY S, et al. Interobserver variability in ultrasound assessment of thyroid nodules[J].Medicine (Baltimore),2022 ,101(41):e31106.
[11] KARAGÜLLE M, ARSLAN F Z,ŞIMŞEK S, et al. Investigation of the effectiveness of microvascular doppler ultrasound and q-pack in the discrimination of malign thyroid nodules from benign[J].Ultrasound Q,2023,39(1):37-46.
[12] 杨光旭,万静,吴作辉,等.超微血管成像评估甲状腺影像报告和数据系统(TI-RADS)4级甲状腺结节血流特征[J].中国医学影像技术,2021,37(6):867-870.
2025, Vol. 42 
