Abstract：【Objective】 To explore the clinical efficacy of Shenshu Tiaozhong Decoction in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) complicated with multidrug resistant bacterial infection.【Methods】 A total of 82 elderly AECOPD patients with multi-drug resistant bacterial infection, who were treated in our hospital from January 2022 to April 2024, were selected and they were randomly divided into an observation group(treated with Shenshu Tiaozhong Decoction in addition to Western medicine) and a control group(treated with Western medicine alone) according to the random number table method, with 41 cases in each group. The therapeutic effects, pathogen clearance rates, adverse reactions, and changes in serum inflammatory factors, immune function indicators, and blood gas indicators before and after treatment were compared between the two groups.【Results】 After treatment, the levels of serum interleukin-6(IL-6), interleukin-8(IL-8) and the proportion of CD8+ T lymphocytes in the observation group were significantly lower than those in the control group(P<0.05), while the proportions of CD3+ and CD4+ T lymphocytes were higher than those in the control group(P<0.05). After treatment, the arterial partial pressure of oxygen(PaO2) in the observation group was higher than that in the control group, and the arterial partial pressure of carbon dioxide(PaCO2) was lower than that in the control group(P<0.05). The total effective rate and pathogen clearance rate in the observation group were significantly higher than those in the control group(P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 The application of Shenshu Tiaozhong Decoction in the treatment of elderly AECOPD patients with multi-drug resistant bacterial infection can significantly alleviate the inflammatory response, improve immune function and blood gas indicators, increase the pathogen clearance rate, and is highly safe.
2025, Vol. 42 
