Abstract：【Objective】To investigate the factors influencing the occurrence of intestinal obstruction in patients with gastrointestinal tumors following laparoscopic radical surgery and subsequent chemotherapy.【Methods】A total of 162 patients who underwent laparoscopic radical surgery and postoperative chemotherapy for gastrointestinal tumors were followed for 30 days postoperatively. The incidence of intestinal obstruction was recorded. Univariate and multivariate Logistic regression analyses were performed to identify factors associated with the development of intestinal obstruction.【Results】Among the 162 patients, 13 cases developed intestinal obstruction within 30 days postoperatively, yielding an incidence rate of 8.02%. Factors showing significantly more prevalent in the obstruction group compared to the non-obstruction group included: male gender, age ≥70 years, tumor stage Ⅲ-Ⅳ, preoperative hypoproteinemia, history of preoperative intestinal obstruction, history of abdominal surgery, operative time ≥2 hours, combined organ resection, use of antiemetic drugs post-chemotherapy, time to first flatus ≥48 hours, time to first defecation ≥72 hours, time to recovery of bowel sounds ≥72 hours, and time to postoperative feeding ≥96 hours (P<0.05). Multivariate logistic regression analysis identified gender, age, tumor stage, preoperative hypoproteinemia, history of abdominal surgery, combined organ resection, use of antiemetic drugs post-chemotherapy, time to first flatus, time to first defecation, time to recovery of bowel sounds, and time to postoperative feeding as significant factors influencing the occurrence of intestinal obstruction (P<0.05).【Conclusion】The development of intestinal obstruction following chemotherapy after laparoscopic radical surgery in patients with gastrointestinal tumors is influenced by multiple factors, including gender, age, tumor stage, preoperative hypoproteinemia, history of abdominal surgery, combined organ resection, and use of antiemetic drugs post-chemotherapy. Clinicians should proactively implement preventive measures to minimize the risk of intestinal obstruction.
黄元哲, 张定喜, 邹浩洋. 胃肠道肿瘤患者腹腔镜根治术后化疗并发肠梗阻的影响因素[J]. 医学临床研究, 2025, 42(6): 974-977.
HUANG Yuanzhe, ZHANG Dingxi, ZOU Haoyang. Influencing Factors of Intestinal Obstruction Following Chemotherapy after Laparoscopic Radical Surgery in Patients with Gastrointestinal Tumors. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 974-977.
2025, Vol. 42 
