Abstract：【Objective】To investigate the effect of single injection of dexmedetomidine (Dex) on hemodynamics in patients undergoing laparoscopic myomectomy (LM). 【Methods 】A total of 90 patients with LM were randomly divided into two groups, 45 cases in each group. Dex was injected once in the observation group before anesthesia induction, while Dex was injected continuously in the control group before anesthesia induction. The clinical indexes, hemodynamic parameters, serological indexes, adverse reactions and sleep quality were compared between the two groups. 【Results】There was no significant difference in operation time between the two groups (P>0.05). The extubation time, anesthesia recovery time and postoperative recovery time in the observation group were shorter than those in the control group (P<0.05). There were no significant differences in mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SPO2) between the two groups before anesthesia induction (P>0.05), and there were no significant differences in HR and SPO2 between the two groups after anesthesia induction (P>0.05). After anesthesia induction, MAP and HR levels in both groups were higher than before induction (P<0.05), and MAP in observation group was lower than control group (P<0.05). There was no significant difference in the levels of epinephrine (E), aldosterone (ALD) and cortisol (Cor) between the two groups before surgery (P>0.05), and the three indexes of the two groups were lower than those of the two groups before surgery (P<0.05), and the three indexes of the observation group were higher than those of the control group (P<0.05). There was no significant difference in Pittsburgh sleep quality index (PSQI) scores between the two groups 1 week after surgery (P>0.05), and PSQI scores in the observation group were lower than those in the control group 2 weeks and 3 weeks after surgery (P<0.05). 【Conclusion】Single injection of Dex has a good anesthetic effect in patients with LM, which is conducive to the stability of hemodynamic indexes of the body.
姚莺, 刘智慧, 王学勤. 单次注射右美托咪定对腹腔镜子宫肌瘤剔除术患者血流动力学参数的影响[J]. 医学临床研究, 2025, 42(6): 1037-1039.
YAO Ying, LIU Zhihui, WANG Xueqin. Effect of Single Injection of Dexmedetomidine on Hemodynamic Parameters of Patients Undergoing Laparoscopic Myomectomy. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1037-1039.
2025, Vol. 42 
