Abstract：【Objective】To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and Ki-67 in cancer tissues and the postoperative prognosis of primary liver cancer (HCC).【Methods】A total of 103 HCC patients admitted to the hospital from June 2015 to June 2018 were selected. All patients underwent HCC radical surgery and postoperative prophylactic transcatheter arterial chemoembolization, and were followed up for 3 years after surgery. We detected and compared the expression of EGFR and Ki-67 in cancer tissues and adjacent tissues, analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and pathological factors, analyzed the factors affecting the prognosis of HCC radical surgery, and analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and postoperative prognosis of HCC.【Results】The positive expression rates of EGFR and Ki-67 in cancer tissues were higher than those in adjacent tissues (P<0.05). The positive expression rates of EGFR and Ki-67 in cancer tissues of patients with microvascular tumor thrombus, incomplete tumor capsule, clinical stage Ⅲ, and low differentiation were higher than those of patients without microvascular tumor thrombus, intact tumor capsule, clinical stage Ⅰ-Ⅱ, and moderately to well differentiated patients (P<0.05). Cox regression analysis showed that microvascular tumor thrombus, tumor capsule, clinical stage, differentiation degree, EGFR expression, Ki-67 expression were related factors affecting disease-free survival rate (P<0.05); Tumor capsule, clinical stage, differentiation degree, EGFR expression, and Ki-67 expression are related factors affecting overall survival rate (P<0.05). The disease-free survival rate and overall survival rate of EGFR and Ki-67 negative expression patients were better than those of positive expression patients, and the differences were statistically significant (P<0.05).【Conclusion】EGFR and Ki-67 are abnormally overexpressed in cancer tissues of HCC patients. EGFR and Ki-67 expression are associated with the pathology and prognosis of HCC patients after surgery, and those with positive expression have a higher risk of poor prognosis.
王晓建. EGFR、Ki-67表达与原发性肝癌根治性手术预后的相关性[J]. 医学临床研究, 2024, 41(8): 1160-1163.
WANG Xiaojian. The Correlation between EGFR and Ki-67 Expression and the Prognosis of Radical Surgery for Primary Liver Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(8): 1160-1163.
[1] CRAIG AJ, VON FELDEN J, GARCIA-LEZANA T, et al. Tumour evolution in hepatocellular carcinoma[J].Nat Rev Gastroenterol Hepatol,2020, 17(3):139-152.
[2] 张加辉, 徐丽萍, 赵志新, 等. 基于MR影像组学及临床特征预测混合型肝癌和肿块型肝内胆管细胞癌术后生存[J].临床放射学杂志, 2022, 41(2):279-283.
[3] BAGHDADI I, ABU ELLA K, EL SHAARAWAY A, et al.Genetic polymorphism of epidermal growth factor gene as a predictor of hepatocellular carcinoma in hepatitis C cirrhotic patients[J].Asian Pac J Cancer Prev,2020, 21(7):2047.
[4] HEMMAT N, MOKHTARZADEH A, AGHAZADEH M, et al. Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer[J].Mol Biol Rep,2020, 47(6):4553-4568.
[5] 魏复群, 罗柳平, 梁东, 等. Ki-67表达与原发性肝癌根治性切除术后行预防性肝动脉化疗栓塞患者预后的关系[J].中国普通外科杂志, 2019, 28(7):825-832.
[6] 郭飞宇, 杨军, 熊书名, 等. 表皮生长因子受体和胸苷酸合成酶在原发性肝癌中的表达和意义[J].中华肝脏病杂志, 2018, 26(9):666-669.
[7] 中国抗癌协会肝癌专业委员会, 中华医学会肝病学分会肝癌学组, 中国抗癌协会病理专业委员会, 等.原发性肝癌规范化病理诊断指南(2015年版)[J].中华肝胆外科杂志, 2015, 21(3):145-151.
[8] 林斌, 周智鹏, 戴文海, 等. 2018版肝脏影像报告与数据系统肝胆期低信号对肝细胞癌的诊断效能[J].实用放射学杂志, 2022, 38(1):68-72.
[9] 姜梅, 高德宏, 张凯, 等. CT平均动脉增强分数彩图在肝细胞型肝癌中的诊断价值[J].实用放射学杂志, 2020, 36(4):583-587.
[10] 冀柏宇, 金栋, 郝芬林, 等. NLR与经导管动脉化疗栓塞联合局部消融治疗肝切除术后复发性肝癌患者预后的相关性[J].实用放射学杂志, 2022, 38(8):1342-1346.
[11] ZHANG Y G, WANG F, ZHANG H, et al. VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR-PI3K-AKT pathway[J].Oncogene,2020, 39(6):1213-1230.
[12] TUMBRINK H L, HEIMSOETH A, SOS M L. The next tier of EGFR resistance mutations in lung cancer[J].Oncogene,2021, 40(1):1-11.
[13] 许露露, 舒健, 杨春梅. MRI纹理特征与肝细胞肝癌Ki-67表达的相关性[J].放射学实践, 2020, 35(9):1127-1131.
2024, Vol. 41 
