Abstract：【Objective】To explore the relationship of peripheral blood macrophage migration inhibitory factor (MIF) with the severity of sepsis to predict complication of acute respiratory distress syndrome (ARDS). 【Methods】A total of 95 patients with sepsis admitted to the hospital were selected. The basic data of all patients and biochemical indicators before treatment were collected. Patients were followed up for 2 weeks after treatment. Peripheral blood MIF,acute physiology and chronic health score Ⅱ(APACHE Ⅱ),and sequential organ failure assessment (SOFA) scores of sepsis patients with different severity levels were analyzed. Factors affecting ARDS in patients with sepsis were analyzed. And the value of peripheral blood MIF in predicting ARDS in patients with sepsis was analyzed as well. 【Results】The scores of MIF,APACHE Ⅱ and SOFA in the septic shock group were higher than those in the sepsis group (P<0.05). Pearson correlation analysis showed that the level of MIF in patients with sepsis was positively correlated with APACHE Ⅱ score and SOFA score (P<0.05). Logistic multivariate regression analysis showed that APACHE Ⅱ score,MIF,and oxygenation index were independent factors that affected patients with sepsis complicated by ARDS (P<0.05). ROC curve analysis showed that the sensitivity,specificity,and area under AUC of peripheral blood MIF in predicting sepsis patients with ARDS were 71.43%,79.66%,and 0.778,respectively. 【Conclusion】The level of peripheral blood MIF in patients with sepsis is related to the severity of the disease and ARDS complication. MIF is effective in predicting ARDS in patients with sepsis.
卞茂成, 钟斐, 万健. 外周血MIF与脓毒症患者病情严重程度的相关性及预测ARDS发生的价值[J]. 医学临床研究, 2023, 40(2): 176-179.
BIAN Mao-cheng, ZHONG Fei, WAN Jian. Study on Relationship of Peripheral Blood MIF with Severity of Sepsis for Predictive Value of ARDS. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 176-179.
2023, Vol. 40 
