DAO、D-LA及APACHE Ⅱ、GCSI-R评分对急性胰腺炎患者病情严重程度及预后的评估价值

doi:10.3969/j.issn.1671-7171.2022.10.004

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摘要【目的】探讨二胺氧化酶(DAO)、D-乳酸(D-LA)及急性生理与慢性健康状况Ⅱ(APACHE Ⅱ)评分、修订版胃瘫主要症状指数(GCSI-R)评分评估急性胰腺炎(AP)患者病情严重程度及预后的价值。【方法】选取100例AP患者的临床资料,根据病情严重程度分为轻症组(n=59)、中症组(n=29)、重症组(n=12),根据入院后28 d内是否死亡分为存活组(n=92)与死亡组(n=8)。比较不同病情严重程度及不同预后AP患者血清DAO、D-LA及APACHE Ⅱ评分、GCSI-R评分,通过Spearman相关系数分析血清DAO、D-LA及APACHE Ⅱ评分、GCSI-R评分与AP患者病情严重程度的相关性,采用受试者工作特征曲线(ROC曲线)分析上述指标评估AP患者预后的价值。【结果】三组血清DAO、D-LA及APACHE Ⅱ评分、GCSI-R评分比较,轻症组＜中症组＜重症组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,AP患者病情严重程度与血清DAO、D-LA及APACHE Ⅱ评分、GCSI-R评分呈正相关(P<0.05);存活组患者血清DAO、D-LA及APACHE Ⅱ评分、GCSI-R评分均显著低于死亡组,差异有统计学意义(P<0.05);经ROC曲线分析,DAO≥42.315 mg/L、D-LA≥40.690 U/L、APACHE Ⅱ评分≥26.000分、GCSI-R评分≥12.585分是评估AP患者预后的最佳截断值(P<0.05)。【结论】DAO、D-LA及APACHE Ⅱ、GCSI-R评分可用于反映AP患者病情严重程度及预后,且与AP病情严重程度呈正相关。

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	范波
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关键词 ：胰腺炎, 急性病, 胺氧化酶(含铜), 乳酸, 急性病生理学和长期健康评价, 预后, 病人病情

Abstract：【Objective】 To study the value of diamine oxidase (DAO), D-lactic acid (D-LA), acute physiology and chronic health Ⅱ (APACHE Ⅱ) score, and revised major symptom index of gastroparesis (GCSI-R) score in evaluating the severity and prognosis of acute pancreatitis (AP).【Methods】A total of 100 patients with AP were divided into mild (n=59), moderate (n=29) and severe (n=12) groups according to the severity of the disease. They were divided into survival (n=92) and death (n=8) groups according to whether they died within 28 days after admission. The serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score of AP patients with different severity and prognosis were compared;Spearman correlation coefficient was used to analyze the relationship between serum DAO, D-LA, APACHE Ⅱ score, GCSI-R score and severity of AP patients;The prognostic value of AP patients was evaluated by ROC analysis of serum DAO, D-LA,APACHE Ⅱ score and GCSI-R score.【Results】 Compared with serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score, the difference was statistically significant between mild group and moderate group and severe group(P<0.05);By correlation analysis, the severity of AP patients was positively correlated with serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score (P<0.05); The serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score in the survival group were significantly lower than those in the death group (P<0.05); ROC analysis showed that DAO ≥ 42.315 mg/L, D-LA ≥ 40.690 U/L, APACHE Ⅱ score ≥ 26.000, GCSI-R score ≥ 12.585 were the best cut-off values for evaluating the prognosis of AP patients, all of which were P<0.05. 【Conclusion】DAO, D-LA, APACHE Ⅱ and GCSI-R scores can be used to reflect the severity and prognosis of AP patients, and are positively correlated with the severity of AP.

Key words： Pancreatitis Acute Disease Amine Oxidase(Copper-Containing) Lactic Acid APACHE Prognosis Patient Acuity

收稿日期: 2022-02-24

中图分类号:

R576.1

基金资助:陕西省重点研发计划项目(NO:2017ZDXM-SF-25-5)

通讯作者: **E-mail:593235965@qq.com

引用本文:

范波, 闫润生. DAO、D-LA及APACHE Ⅱ、GCSI-R评分对急性胰腺炎患者病情严重程度及预后的评估价值[J]. 医学临床研究, 2022, 39(10): 1452-1455.
FAN Bo, YAN Run-sheng. Value of DAO, D-LA, APACHE Ⅱ and GCSI-R Scores in Evaluating the Severity and Prognosis of Acute Pancreatitis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1452-1455.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.10.004 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I10/1452

[1] JEAN E M,CHO J,TREVINO J G. A case report of recurrent acute pancreatitis associated with life threatening atypical hemolytic uremic syndrome[J].Medicine,2020,99(5):774-779.
[2] BERG F,BRUJIN A,SANTVOORT H,et al. Early laboratory biomarkers for severity in acute pancreatitis; A systematic review and meta-analysis[J].Pancreatology,2020,74(5):647-679.
[3] SAT H,KAYAHAN N,SARGN Z G,et al. Evaluation of the clinical course and prognostic indices of acute pancreatitis in elderly patients :a prospective study[J].Acta Gastroenterol Belg,2020,44(5):54-59.
[4] BORGES F,SILVA S,CARVALHO N,et al. Comparison of HAPS,BISAP and NLR as predictors of severity in acute pancreatitis (Atlanta 2012)[J].HPB(Oxford),2020,22(4):273-279.
[5] 金梦,张慧敏,陈轩馥,等. 急性胰腺炎相关胃肠道衰竭的评价和早期诊断指标[J].中国医学科学院学报,2020,42(1):847-851.
[6] 中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编辑委员会,《中华消化杂志》编辑委员会. 中国急性胰腺炎诊治指南(2019,沈阳)[J].中华胰腺病杂志,2019,19(5):321-331.
[7] HASHMI A,SMITH E I,CIUTAC A,et al. Lesson of the month:Acute pancreatitis due to hypertriglyceridaemia in a transgender woman:a complication of high-dose oral oestrogen therapy?[J].Clin Med(London,England),2021,21(3):228-230.
[8] KURKCU K,KARA B,KOC A S,et al. A practical means of evaluating the prognosis of acute pancreatitis :measurement of carotid artery intima-media thickness[J].Acta Gastro-Enterologica Belgica,2021,84(3):48-53.
[9] 许迪,李丽,冯子南,等. 健脾益气法对重症急性胰腺炎患者免疫功能,炎症反应及肠道黏膜屏障功能的影响[J].中国现代医学杂志,2020,30(20):503-506.
[10] 田融冰,朱红林,杨森林,等. 生长抑素持续静脉滴注治疗对重症急性胰腺炎患者胃肠道功能的影响[J].解放军医药杂志,2020,32(7):442-445.
[11] 徐玉龙,管建国,宗桂荣,等. 急性胰腺炎患者血清二胺氧化酶及D-乳酸水平与肠道功能的关系[J].重庆医学,2021,50(15):481-483.
[12] 张福鑫,郑扬,涂攀. 急性胰腺炎患者MIP-1α和MIP-1β及APACHE Ⅱ评分与感染及病情严重程度的相关性研究[J].中华医院感染学杂志,2019,29(19):2991-2993.
[13] 杨淑洁. CT严重指数结合APACHE-Ⅱ评分对急性胰腺炎严重程度及预后的评估[J].中国CT和MRI杂志,2020,18(2):400-404.