Abstract：【Objective】To investigate the influencing factors of fungal septicemia in extremely low/ultra-low birth weight premature infants. 【Methods】A total of 181 cases of extremely low/ultra-low birth weight preterm infants admitted to the preterm intensive care unit of Hunan Children's Hospital from January 2016 to December 2020 were selected and divided into the observation group (with positive blood fungal culture,n=21) and the control group (with negative blood fungal culture,n=160) according to the occurrence of positive blood fungal culture. The clinical data of the two groups were collected and compared retrospectively. Logistic regression was used to analyze the related influencing factors of fungal sepsis. The results of bacterial strain culture and drug sensitivity were analyzed,while the drug use and outcome of the children were recorded. 【Results】There were no significant differences between the two groups in terms of gender,vaginal delivery,birth asphyxia,premature rupture of membranes,use of pulmonary surfactant (PS) and complication with chronic lung disease (P>0.05). There were significant differences in the combined use of antibiotics for ≥7 days,parenteral nutrition for ≥14 days,PICC indwelling for ≥14 days,and invasive mechanical ventilation for ≥7 days (P<0.05). Logistic regression analysis showed that the combined use of antibiotics ≥7 days,PICC indwelling ≥14 days,and invasive mechanical ventilation ≥7 days were independent risk factors for fungal sepsis in extremely low and ultra-low birth weight preterm infants (P<0.05).Parenteral nutrition ≥14 days was a non-independent risk factor for fungal sepsis in extremely low and ultra-low birth weight preterm infants (P>0.05). 【Conclusion】Fungal sepsis in extremely low and ultra-low birth weight preterm infants is mostly nosocomial infection. Rational use of antibiotics,strengthening the management of PICC and shortening the duration of invasive mechanical ventilation can reduce the infection rate of fungal sepsis.
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2022, Vol. 39 
