卡维地洛对老年高血压合并冠心病患者氧化应激反应及血管内皮功能的影响

doi:10.3969/j.issn.1671-7171.2023.12.035

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摘要【目的】探讨卡维地洛对老年高血压合并冠心病患者氧化应激反应及血管内皮功能的影响。【方法】选取2019年3月至2022年3月本院收治的84例老年高血压合并冠心病患者,采用随机数字表法将其分为观察组与对照组,每组42例。对照组给予美托洛尔,观察组在对照组基础上给予卡维地洛。比较两组心功能指标[心率(HR)、左心室射血分数(LVEF)、左心室舒张末期内径(LVDD)、心排血量(CO)],比较两组氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-P)]水平,比较两组血管内皮功能指标[肾上腺髓质(AM)、内皮素1(ET-1)、一氧化氮(NO)]水平,观察并比较两组不良反应发生情况。【结果】治疗后,两组HR、LVDD水平均低于治疗前,LVEF、CO高于治疗前,且观察组HR、LVDD低于对照组,LVEF、CO高于对照组,差异有统计学意义(P<0.05);两组SOD、GSH-P水平高于治疗前,MDA水平低于治疗前,且观察组SOD、GSH-P水平高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05);两组AM、ET-1水平低于治疗前,NO水平高于治疗前,且观察组AM、ET-1水平低于对照组,NO水平高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为16.67%(7/42),与对照组的23.81%(10/42)比较,差异无统计学意义(χ²=0.664,P>0.05)。【结论】卡维地洛能够有效改善患者心功能及血管内皮功能,减轻患者氧化应激反应,且具有安全性,具有临床应用价值。

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	王圆
	赵立丹

关键词 ：高血压/并发症, 冠心病/并发症, 卡维地洛/治疗应用, 氧化性应激, 内皮,血管

Abstract：【Objective】 To explore the effects of carvedilol on oxidative stress response and endothelial function in elderly hypertensive patients with coronary heart disease. 【Methods】A total of 84 elderly patients with hypertension and coronary heart disease admitted to our hospital from March 2019 to March 2022 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 42 cases in each group. The control group was given metoprolol, while the observation group was given carvedilol on the basis of the control group. Compare two sets of cardiac function indicators[Heart rate (HR), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDD), cardiac output (CO)].Two sets of oxidative stress indicators, levels of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-P) were detected and compared. We compared the levels of two groups of vascular endothelial function indicators [adrenal medulla (AM), endothelin-1 (ET-1), and nitric oxide (NO)], and observed the occurrence of adverse reactions between the two groups.【Results】After treatment, the average levels of HR and LVDD in the two groups were lower than before treatment, while LVEF and CO were higher than before treatment. In addition, the HR and LVDD in the observation group were lower than those in the control group, while LVEF and CO were higher than those in the control group, with statistical significance (P<0.05); The levels of SOD and GSH-P in the two groups were higher than before treatment, while the levels of MDA were lower than before treatment. In addition, the levels of SOD and GSH-P in the observation group were higher than those in the control group, and the levels of MDA were lower than those in the control group, with statistical significance (P<0.05); The levels of AM and ET-1 in the two groups were lower than before treatment, and the levels of NO were higher than before treatment. In addition, the levels of AM and ET-1 in the observation group were lower than those in the control group, and the levels of NO were higher than those in the control group, with statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 16.67% (7/42), while in the control group it was 23.81% (10/42), with no statistically significant difference(χ²=0.664, P>0.05). 【Conclusion】 Carvedilol can effectively improve patient cardiac and endothelial function, alleviate oxidative stress response, and has safety and clinical application value.

Key words： Coronary Disease/CO Coronary Disease/CO Carvedilol/TU Oxidative Stress Endothelium, Vascular

收稿日期: 2022-07-13

中图分类号:

R544.1

通讯作者: *E-mail:29504698@qq.com

引用本文:

王圆, 赵立丹. 卡维地洛对老年高血压合并冠心病患者氧化应激反应及血管内皮功能的影响[J]. 医学临床研究, 2023, 40(12): 1943-1946.
WANG Yuan,ZHAO Lidan. The Effects of Carvedilol on Oxidative Stress Response and Endothelial Function in Elderly Hypertensive Patients with Coronary Heart Disease. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1943-1946.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.12.035 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I12/1943

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