Abstract：【Objective】 To explore the effects of carvedilol on oxidative stress response and endothelial function in elderly hypertensive patients with coronary heart disease. 【Methods】A total of 84 elderly patients with hypertension and coronary heart disease admitted to our hospital from March 2019 to March 2022 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 42 cases in each group. The control group was given metoprolol, while the observation group was given carvedilol on the basis of the control group. Compare two sets of cardiac function indicators[Heart rate (HR), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDD), cardiac output (CO)].Two sets of oxidative stress indicators, levels of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-P) were detected and compared. We compared the levels of two groups of vascular endothelial function indicators [adrenal medulla (AM), endothelin-1 (ET-1), and nitric oxide (NO)], and observed the occurrence of adverse reactions between the two groups.【Results】After treatment, the average levels of HR and LVDD in the two groups were lower than before treatment, while LVEF and CO were higher than before treatment. In addition, the HR and LVDD in the observation group were lower than those in the control group, while LVEF and CO were higher than those in the control group, with statistical significance (P<0.05); The levels of SOD and GSH-P in the two groups were higher than before treatment, while the levels of MDA were lower than before treatment. In addition, the levels of SOD and GSH-P in the observation group were higher than those in the control group, and the levels of MDA were lower than those in the control group, with statistical significance (P<0.05); The levels of AM and ET-1 in the two groups were lower than before treatment, and the levels of NO were higher than before treatment. In addition, the levels of AM and ET-1 in the observation group were lower than those in the control group, and the levels of NO were higher than those in the control group, with statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 16.67% (7/42), while in the control group it was 23.81% (10/42), with no statistically significant difference(χ2=0.664, P>0.05). 【Conclusion】 Carvedilol can effectively improve patient cardiac and endothelial function, alleviate oxidative stress response, and has safety and clinical application value.
王圆, 赵立丹. 卡维地洛对老年高血压合并冠心病患者氧化应激反应及血管内皮功能的影响[J]. 医学临床研究, 2023, 40(12): 1943-1946.
WANG Yuan,ZHAO Lidan. The Effects of Carvedilol on Oxidative Stress Response and Endothelial Function in Elderly Hypertensive Patients with Coronary Heart Disease. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1943-1946.
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2023, Vol. 40 
