急性后循环缺血性脑梗死血管再通前后血清Pannexin1水平变化及其与临床病理特征的关系

doi:10.3969/j.issn.1671-7171.2023.07.030

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1214 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨急性后循环缺血性脑梗死患者血管再通前后血清泛连接蛋白(Pannexin1)水平变化及其与临床特征的关系。【方法】选择82例急性后循环缺血性脑梗死血管再通患者作为研究对象,比较患者血管再通前后血清Pannexin1水平,分析患者血清Pannexin1水平与脑梗死体积及美国国立卫生研究院卒中量表(NIHSS)评分的相关性,并评估血清Pannexin1水平对患者预后的预测价值。【结果】血管再通后患者血清Pannexin1水平低于再通前(P<0.05);再通前后轻度神经功能缺损组血清Pannexin1水平均低于重度神经功能缺损组(P<0.05);轻度脑梗死组均低于重度脑梗死组(P<0.05);预后良好组均低于预后不佳组(P<0.05)。血管再通后各组组内Pannexin1水平均低于血管再通前(均P<0.05)。血清Pannexin1水平与脑梗死体积及NIHSS评分均呈正相关(r_s=0.649、0.614,P<0.05);受试者工作特征(ROC)曲线分析显示,血清Pannexin1水平预测患者预后的ROC曲线下面积(AUC)为0.778。【结论】急性后循环缺血性脑梗死患者血清Pannexin1水平较正常受试者偏高,且血清Pannexin1水平与脑梗死体积及NIHSS评分均呈正相关,对评估患者的临床预后具有一定的临床参考价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	梁鎏明
	高雨薇
	杜奉荣
	王超

关键词 ：脑梗死, 急性病, 血管/生理学, 连接蛋白/血液

Abstract：【Objective】To investigate the level changes of serum Pannexin1 and its relationship with clinical characteristics in patients with acute post-circulatory ischemic stroke before and after vascular recanalization. 【Methods】A total of 82 patients with acute post-circulatory ischemic stroke who underwent vascular recanalization were selected as the study subjects. Serum Pannexin1 levels before and after vascular recanalization were compared, and the correlation of serum Pannexin1 levels with stroke volume and NIHSS score was analyzed. The predictive value of serum Pannexin1 level for patient prognosis was also evaluated. 【Results】Serum Pannexin1 level was lower after vascular recanalization compared to before recanalization (P<0.05). Mild neurological deficit group had significantly lower serum Pannexin1 level than the severe neurological deficit group before and after recanalization (P<0.05). The mild stroke group had lower serum Pannexin1 level than the severe stroke group (P<0.05). The good prognosis group had lower serum Pannexin1 level than the poor prognosis group (P<0.05). The serum Pannexin1 levels in all groups after vascular recanalization were lower than those before recanalization (all P<0.05). Serum Pannexin1 level was positively correlated with stroke volume and NIHSS score (r_s=0.649, 0.614, P<0.05). ROC analysis showed that the area under the curve (AUC) of serum Pannexin1 level for predicting patient prognosis was 0.778. 【Conclusion】Serum Pannexin1 level is elevated in patients with acute post-circulatory ischemic stroke compared to healthy volunteers, and the level of Pannexin1 is positively correlated with stroke volume and NIHSS score, which can provide certain reference value for the clinical prognosis of patients with acute posterior circulation ischemic cerebral infarction.

Key words： Brain Infarction Acute Disease Blood Vessels/PH Nectins

收稿日期: 2022-11-21

中图分类号:

R743.33

通讯作者: *E-mail:1443787033@qq.com

引用本文:

梁鎏明, 高雨薇, 杜奉荣, 王超. 急性后循环缺血性脑梗死血管再通前后血清Pannexin1水平变化及其与临床病理特征的关系[J]. 医学临床研究, 2023, 40(7): 1066-1069.
LIANG Liu-ming, GAO Yu-wei, DU Feng-rong, et al. Changes of Serum Pannexin1 Levels before and after Recanalization of Acute Posterior Circulation Ischemic Cerebral Infarction and its Relationship with Clinical Features. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1066-1069.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.07.030 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I7/1066

[1] AGUIAR D S D, LUCAS N L, ARAUZ A, et al. Early recanalization in patients with cerebral venous thrombosis treated with anticoagulation[J].Stroke,2020,51(4):1174-1181.
[2] SWEID A, HEAD J, TJOUMAKARIS S, et al. Mechanical thrombectomy in distal vessels:revascularization rates, complications, and functional outcome[J].World Neurosurg,2019,130:e1098-e1104.
[3] OGATA A, EBASHI R, KOGUCHI M, et al. Influence of microcatheter position on first-pass success of thrombectomy for acute ischemic stroke[J].World Neurosurg,2021,146:e708-e713.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组,中华医学会神经病学分会神经血管介入协作组. 中国急性缺血性脑卒中早期血管内介入诊疗指南2018[J].中华神经科杂志,2018,51(9):683-691.
[5] LEKER R R, KASNER S E, EL H H, et al. Impact of carotid tortuosity on outcome after endovascular thrombectomy[J].Neurol Sci,2021,42(6):2347-2351.
[6] NOGUEIRA R C, LAM M Y, LLWYD O, et al. Cerebral autoregulation and response to intravenous thrombolysis for acute ischemic stroke[J].Sci Rep,2020,10(1):10554.
[7] SCEMES E, VELISEK L, VELISKOVA J. Astrocyte and neuronal pannexin1 contribute distinctly to seizures[J].ASN Neuro,2019,11(5):166-168.
[8] BIALECKI J, WERNER A, WEILINGER N L, et al. Suppression of presynaptic glutamate release by postsynaptic metabotropic NMDA receptor signalling to pannexin-1[J].J Neurosci,2020,40(4):729-742.
[9] 辛家厚,杨玲玲,俞明明,等. 急性缺血性脑卒中患者血清Pannexin1水平变化及其与病情严重程度和预后的关系[J].中风与神经疾病杂志,2021,38(3):209-212.
[10] LAGOS-CABRE R, BURGOS-BRAVO F, AVALOS A M, et al. Connexins in astrocyte migration[J].Front Pharmacol,2019,10(5):1546.
[11] GAJARDO-GOMEZ R, SANTIBANEZ C A, LABRA V C, et al. HIV gp120 protein increases the function of connexin 43 hemichannels and pannexin-1 channels in astrocytes:repercussions on astroglial function[J].Int J Mol Sci,2020,21(7):187-189.