医学临床研究
  2025年4月5日 星期六           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2023, Vol. 40 Issue (6): 920-923    DOI: 10.3969/j.issn.1671-7171.2023.06.034
  论著 本期目录 | 过刊浏览 | 高级检索 |
HDGF、VEGF表达与肝癌患者病灶浸润转移风险的相关性
王晓锋1, 王菁菁2,*
1.西安市第三医院西北大学附属医院,陕西 西安 710018;
2.陕西省安康市中心医院,陕西 安康 725000
The Correlation between the Expression of HDGF and VEGF and the Risk of Lesion Infiltration and Metastasis in Liver Cancer Patients
WANG Xiao-feng, WANG Jing-jing
Xi'an Third Hospital Northwest University Hospital,Xi'an Shaanxi 710018
全文: PDF (1133 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】 探讨肝癌衍生生长因子(HDGF)、血管内皮生长因子(VEGF)表达与肝癌患者病灶浸润转移风险的相关性。【方法】 回顾性分析2019年7月至2022年7月西安市第三医院西北大学附属医院收治的82例接受手术切除治疗的肝癌患者的临床资料,收集患者的肝癌组织标本和癌旁组织。采用免疫组化染色法检测肝癌组织及癌旁组织内HDGF、VEGF表达情况,比较不同临床病理特征肝癌患者HDGF、VEGF表达水平,采用多因素logistic回归分析影响肝癌组织HDGF、VEGF表达的危险因素。【结果】 肝癌组织中HDGF、VEGF阳性表达率高于癌旁组织,差异有统计学意义(P<0.05)。不同AJCC分期、包膜完整性和肿瘤转移的肝癌组织HDGF、VEGF表达比较,差异有统计学意义(P<0.05)。多因素Logistic回归模型分析显示,AJCC分期、包膜完整性和肿瘤转移是肝癌组织HDGF、VEGF表达的影响因素(P<0.05)。【结论】 肝癌组织中HDGF、VEGF呈高表达,且与AJCC分期、包膜完整性和肿瘤转移相关,对评估肝癌进展有一定的参考价值。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
王晓锋
王菁菁
关键词 肝肿瘤/病理学血管内皮生长因子A肿瘤转移肿瘤浸润数据相关性    
Abstract:【Objective】 To investigate the correlation between the expression of hepatoma derived growth factor (HDGF),Vascular endothelial growth factor (VEGF) and the risk of invasion and metastasis of liver cancer. 【Methods】 A retrospective analysis was conducted on the clinical data of 82 liver cancer patients who underwent surgical resection treatment at the Northwest University Affiliated Hospital of Xi'an Third Hospital from July 2019 to July 2022. Liver cancer tissue samples and adjacent tissues were collected from the patients. Immunohistochemical staining was used to detect the expression of HDGF and VEGF in liver cancer tissue and adjacent tissues,and to compare the expression of HDGF and VEGF in liver cancer patients with different clinical and pathological characteristics. Multivariate logistic regression analysis was used to analyze the risk factors affecting the expression of HDGF and VEGF in liver cancer tissue. 【Results】 The positive expression rates of HDGF and VEGF in liver cancer tissues were higher than those in adjacent tissues,and the difference was statistically significant (P<0.05). There was a statistically significant difference in the expression of HDGF and VEGF in liver cancer tissues with different AJCC stages,capsule integrity,and tumor metastasis (P<0.05). Multivariate logistic regression model analysis showed that AJCC stage,capsule integrity,and tumor metastasis were influence factors affecting the expression of HDGF and VEGF in liver cancer tissue (P<0.05). 【Conclusions】 HDGF and VEGF are highly expressed in liver cancer tissue,and are related to AJCC staging,capsule integrity,and tumor metastasis,which has certain reference value for evaluating liver cancer progression.
Key wordsLiver Neoplasms/PA    Vascular Endothelial Growth Factor A    Neoplasm Metastasis    Neoplasm Invasiveness    Correlation of Data
收稿日期: 2022-08-04     
中图分类号:  R735.7  
通讯作者: *E-mail:akjiji@yeah.net   
引用本文:   
王晓锋, 王菁菁. HDGF、VEGF表达与肝癌患者病灶浸润转移风险的相关性[J]. 医学临床研究, 2023, 40(6): 920-923.
WANG Xiao-feng, WANG Jing-jing. The Correlation between the Expression of HDGF and VEGF and the Risk of Lesion Infiltration and Metastasis in Liver Cancer Patients. JOURNAL OF CLINICAL RESEARCH, 2023, 40(6): 920-923.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.06.034     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I6/920
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn