医学临床研究
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医学临床研究  2022, Vol. 39 Issue (7): 1068-1071    DOI: 10.3969/j.issn.1671-7171.2022.07.030
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动态对比增强扫描MRI定量参数对脑胶质瘤患者预后的预测效能
杨毅1, 师勇2*
1.咸阳市第一人民医院,陕西 咸阳 712000;
2.咸阳市中心医院,陕西 咸阳 712000
Predictive Efficacy of Dynamic Contrast-enhanced MRI Quantitative Parameters on the Prognosis of Glioma
YANG Yi, SHI Yong
The First People's Hospital of Xianyang,Xianyang Shaanxi 712000
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摘要 【目的】探讨动态对比增强扫描磁共振检查(DCE-MRI)定量参数对脑胶质瘤患者预后的预测效能。【方法】选取2017年2月至2020年2月咸阳市第一人民医院收治的114例脑胶质瘤患者,均行DCE-MRI检查,记录定量参数血浆与细胞外血管外间隙间容量转移常数(Ktrans)、血管外细胞外间隙容积分数(Ve),并根据胶质瘤切除术后辅助化疗后无进展生存期(PFS)评估预后。比较不同预后患者一般资料及Ktrans、Ve,采用Logistic回归分析脑胶质瘤预后的影响因素,采用受试者工作特征曲线(ROC曲线)评估Ktrans、Ve对患者预后的预测价值。【结果】114例脑胶质瘤患者中预后不良患者71例,预后良好患者43例;预后不良组年龄、高级别占比大于预后良好患者,KPS评分、术后放疗占比、替莫唑胺使用≥4个疗程低于预后良好患者(P<0.05);预后不良患者DCE-MRI定量参数Ktrans、Ve大于预后良好患者(P<0.05)。多因素Logistic回归分析显示,年龄、肿瘤分级、Ktrans、Ve为预后的危险因素,KPS评分、术后放疗、替莫唑胺使用≥4疗程为预后的保护因素(P<0.05)。ROC曲线分析显示,DCE-MRI定量参数Ktrans、Ve值预测预后的Cut-off值为0.172/min、0.205,AUC值为0.932,0.890。【结论】DCE-MRI定量参数Ktrans、Ve是脑胶质瘤患者预后不良的重要影响因素,对于预后评估具有重要临床预测价值。
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杨毅
师勇
关键词 脑肿瘤/影像诊断神经胶质瘤/影像诊断磁共振成像预后    
Abstract:【Objective】 To investigate the predictive efficacy of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the prognosis of glioma. 【Methods】A total of 114 patients with gliomas admitted to The First People's Hospital of Xianyang from February 2017 to February 2020 were examined by DCE-MRI. The quantitative parameters of plasma extracellular space volume transfer constant (Ktrans) and extravascular extracellular space fraction (Ve) were recorded, and the prognosis was evaluated according to the progression free survival (PFS) after adjuvant chemotherapy after glioma resection. The general data of different prognosis, Ktrans and Ve were compared, the influencing factors of glioma prognosis were analyzed by logistic regression, and the predictive value of Ktrans and Ve on prognosis was evaluated by receiver operating characteristic curve (ROC curve). 【Results】Among 114 patients with glioma, 71 had poor prognosis and 43 had good prognosis; The age and high-grade proportion of patients with poor prognosis were greater than those with good prognosis, and KPS score, postoperative radiotherapy proportion and temozolomide use ≥ 4 courses were lower than those with good prognosis (P<0.05); DCE-MRI quantitative parameters Ktrans and Ve in patients with poor prognosis were greater than those in patients with good prognosis (P<0.05). Multivariate logistic regression analysis showed that age, tumor grade, Ktrans, Ve were risk factors for prognosis, KPS score, postoperative radiotherapy, temozolomide use ≥4 courses were protective factors for prognosis (P<0.05). ROC curve analysis showed that the cut off value of DCE-MRI quantitative parameters Ktrans and Ve to predict prognosis was 0.172/min and 0.205, and the AUC value was 0.932 and 0.890. 【Conclusion】 DCE-MRI quantitative parameters Ktrans and Ve are important factors affecting the poor prognosis of patients with glioma, and have important clinical predictive value for prognosis evaluation.
Key wordsBrain Neoplasms/DG    Glioma/DG    Magnetic Resonance Imaging    Prognosis
收稿日期: 2021-12-13     
中图分类号:  R739.41  
通讯作者: *E-mail:shiyong3154680@sina.com   
引用本文:   
杨毅, 师勇. 动态对比增强扫描MRI定量参数对脑胶质瘤患者预后的预测效能[J]. 医学临床研究, 2022, 39(7): 1068-1071.
YANG Yi, SHI Yong. Predictive Efficacy of Dynamic Contrast-enhanced MRI Quantitative Parameters on the Prognosis of Glioma. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1068-1071.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.07.030     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I7/1068
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