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医学临床研究  2022, Vol. 39 Issue (4): 586-588    DOI: 10.3969/j.issn.1671-7171.2022.04.030
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反复呼吸道感染患儿免疫球蛋白水平与维生素A、超敏C反应蛋白、白介素-1的相关性
欧静琳, 孙义娟*
安康市中医医院,陕西 安康 725000
Correlation between Immunoglobulin Level and Vitamin A, hs-CRP and IL-1 in Children with Recurrent Respiratory Tract Infection
OU Jing-lin, SUN Yi-juan
Ahkang Hospital of Traditional Chinese Medicine, Ahkang shaanxi 725000
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摘要 【目的】探讨反复呼吸道感染患儿免疫球蛋白水平与维生素A、超敏C反应蛋白(hs-CRP)、白介素-1(IL-1)的相关性。【方法】选取2019年9月至2020年9月本院收治的75例反复呼吸道感染患儿(观察组),另选同期75例健康体检的健康儿童作为对照组。比较两组免疫球蛋白(IgA、IgG、IgM)及维生素A、hs-CRP、IL-1水平,采用受试者工作特征(ROC)曲线分析免疫球蛋白及维生素A、hs-CRP、IL-1预测反复呼吸道感染的价值,分析免疫球蛋白水平与维生素A、hs-CRP、IL-1的相关性。【结果】观察组IgA、IgM、IgG、维生素A、IL-1水平显著低于对照组,hs-CRP水平显著高于对照组(P<0.05)。Pearson相关性分析显示,维生素A、IL-1与IgA、IgM、IgG呈正相关(P<0.05),hs-CRP与IgA、IgM、IgG呈负相关(P<0.05)。IgA、IgM、IgG、维生素A、hs-CRP、IL-1预测反复呼吸道感染的曲线下面积(AUC)分别为0.881、0.685、0.665、0.832、0.919、0.966(均P<0.05)。【结论】反复呼吸道感染与免疫球蛋白及维生素A、hs-CRP、IL-1水平密切相关,维生素A、IL-1与免疫球蛋白呈现正相关,可根据患儿具体情况补充适量维生素A。
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欧静琳
孙义娟
关键词 呼吸道感染免疫球蛋白类维生素A/血液C反应蛋白质/血液白细胞介素1/血液儿童    
Abstract:【Objective】To investigate the correlation between immunoglobulin level and vitamin A, high-sensitivity C-reactive protein (hs-CRP) and interleukin-1 (IL-1) in children with recurrent respiratory tract infection. 【Methods】 A total of 75 children with recurrent respiratory tract infection (observation group) treated in our hospital from September 2019 to September 2020 were selected, and 75 healthy children with physical examination in the same period were selected as the control group. The levels of immunoglobulin (IGA, IgG, IgM), vitamin A, hs-CRP and IL-1 were compared between the two groups. The value of immunoglobulin and vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection was analyzed by receiver operating characteristic (ROC) curve, and the correlation between immunoglobulin level and vitamin A, hs CRP and IL-1 was analyzed. 【Results】The levels of IgA, IgM, IgG, vitamin A and IL-1 in the observation group were significantly lower than those in the control group, and the level of hs-CRP was significantly higher than that in the control group (P<0.05). Pearson correlation analysis showed that vitamin A and IL-1 were positively correlated with IgA, IgM and IgG (P<0.05), and hs-CRP was negatively correlated with IgA, IgM and IgG (P<0.05). The AUC of IgA, IgM, IgG, vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection were 0.881, 0.685, 0.665, 0.832, 0.919 and 0.966 respectively (all P<0.05).【Conclusion】 Recurrent respiratory tract infection is closely related to the levels of immunoglobulin, vitamin A, hs-CRP and IL-1. Vitamin A and IL-1 are positively correlated with immunoglobulin. An appropriate amount of vitamin A can be supplemented according to the specific situation of children.
Key wordsRespiratory Tract Infections    Immunoglobulins    Vitamin A/BL    C-Reactive Protein/BL    Interleukin-1/BL    Child
收稿日期: 2021-12-14     
中图分类号:  R56  
通讯作者: *E-mail:153309200@qq.com   
引用本文:   
欧静琳, 孙义娟. 反复呼吸道感染患儿免疫球蛋白水平与维生素A、超敏C反应蛋白、白介素-1的相关性[J]. 医学临床研究, 2022, 39(4): 586-588.
OU Jing-lin, SUN Yi-juan. Correlation between Immunoglobulin Level and Vitamin A, hs-CRP and IL-1 in Children with Recurrent Respiratory Tract Infection. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 586-588.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.04.030     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I4/586
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