Abstract：【Objective】To investigate the effect of serum uric acid level during pregnancy on children with congenital heart disease (CHD). 【Methods】A total of 20 pregnant women who gave birth to CHD children in the obstetrics of our hospital were selected as the observation group, and 100 pregnant women whose offspring did not suffer from CHD in the same period were selected as the control group. The levels of serum uric acid and related indexes were compared between the two groups. The relationship between maternal indexes and offspring CHD was analyzed by binary logistic regression. 【Results】There was no significant difference in average age, gestational weeks, times of delivery and body mass index (BMI) between the two groups (P>0.05). The serum uric acid level, second-hand smoke exposure rate, abortion history and prevalence of hyperuricemia in the observation group were significantly higher than those in the control group, and there were significant differences between the two groups (P<0.05). Univariate logistic regression analysis showed that maternal BMI, second-hand smoke exposure, abortion history and hyperuricemia were correlated with the risk of CHD in offspring (P<0.05), but not with age, gestational week, gestational times and delivery times (P>0.05). The significant indexes of univariate analysis were included in multivariate logistic regression analysis. The results showed that maternal BMI, second-hand smoke exposure, abortion history and hyperuricemia were independent risk factors for CHD in offspring (P<0.05). 【Conclusion】Elevated serum uric acid level is a risk factor for CHD in children. Active treatment of hyperuricemia in pregnant women may reduce the incidence rate of CHD in children.
[1] ARJMANDNIA M, BESHARATI M, REZVAN S.Studying the determinant factors leading to congenital heart disease in newborns[J].J Educ Health Promot,2018, 7(1):53-55.
[2] BREGMAN S, FRISHMAN W H. Impact of improved survival in congenital heart disease on incidence of disease[J].Cardiol Rev,2018,26(2):82-85.
[3] STUBNOVA V, Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure[J].BMC Cardiovasc Disord,2019,19(1): 4-6.
[4] MUN K H. Effect of uric acid on the development of chronic kidney disease: the korean multi-rural communities cohort study[J].J Prev Med Public Health,2018,51(5): 248-256.
[5] KOCAK M Z.Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus[J].Rev Assoc Med Bras,2019,65(1): 9-15.
[6] FEIG D I, KANG D H, JOHNSON R J. Uric acid and cardiovascular risk[J].N Engl J Med,2008, 359(17):1811-1821.
[7] MARELLI A J, IONESCU-ITTU R, MACKIE A S,et al. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010[J].Circulation,2014, 130(9):749-756.
[8] SCHULKEY C E, REGMI S D, MAGNAN R A, et al. The maternal-age-associated risk of congenital heart disease is modifiable[J].Nature,2015, 520(7546):230-233.
[9] LE T M.Maternal serum uric acid concentration and pregnancy outcomes in women with pre-eclampsia/eclampsia[J].Int J Gynaecol Obstet,2019,144(1): 21-26.
[10] RHONE E T, CAMODY J B. Birthweight and serum uric acid in American adolescents[J].Pediatr Int,2017, 59(8):948-950.
[11] PLESKACOVA A. Uric acid and xanthine levels in pregnancy complicated by gestational diabetes mellitus-the effect on adverse pregnancy outcomes[J].Int J Mol Sci,2018,19(11):951-954.
[12] MARTINO J, SEBERT S, SEGURA M T, et al. Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes[J].The J Clin Endocrinol Metab,2015, 101(1):15-18.
[13] CHEN L, XU B, LIU L, et al. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells[J].Lab Invest,2010, 90(5):762-773.
2022, Vol. 39 
