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医学临床研究  2020, Vol. 37 Issue (8): 1148-1150    DOI: 10.3969/j.issn.1671-7171.2020.08.009
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血尿酸水平对糖尿病视网膜病变患者发生糖尿病肾病的影响
胡淑阳, 徐燕, 赵恒霞
中国人民解放军联勤保障部队第904医院,江苏 无锡 214044
Effect of Serum Uric Acid Level on the Risk of Diabetic Nephropathy in Patients with Diabetic Retinopathy
HU Shu-yang, XU Yan, ZHAO Heng-xia
The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu 214044
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摘要 目的】 探讨血清尿酸水平对2型糖尿病视网膜病变(DR)患者发生糖尿病肾病(DN)的影响。【方法】 在本院接受治疗的100例未合并肾脏疾病的2型糖尿病DR患者,检测患者基线血清尿酸水平。对患者进行随访,观察DN发生情况。观察血清尿酸水平与DN发生的相关性,分析2型糖尿病DR患者发生DN的影响因素。【结果】 平均随访(33.2±3.1)个月,无患者失访。共发生DN 23例(23.0%),2年无DN率为87.0%(87/100)。发生DN患者尿酸水平高于未发生DN患者(P<0.05)。Kaplan-Meier并Log-rank检验显示,血尿酸水平升高患者DN累积发生时间短于血尿酸水平降低患者(P<0.05)。Cox分析结果显示,年龄、糖尿病病程、颈动脉粥样斑块、眼底病变程度、空腹血糖、尿酸是2型糖尿病DR患者发生DN的独立影响因素(P<0.05)。ROC分析显示,尿酸预测DR患者发生DN的曲线下面积为0.74,灵敏度为65.2%,特异度为78.9%。【结论】 血清尿酸水平升高的2型糖尿病DR患者发生DN的风险显著增加,且血清尿酸是预测2型糖尿病DR患者发生DN的有效生物学标志物。
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胡淑阳
徐燕
赵恒霞
关键词 糖尿病/并发症糖尿病视网膜病糖尿病肾病尿酸    
Abstract:【Objective】 To investigate the effect of serum uric acid level on the risk of diabetic nephropathy (DN) in patients with type 2 diabetic retinopathy (DR). 【Methods】 A total of 100 patients with type 2 diabetes mellitus without diabetic retinopathy in our hospital were enrolled in the study. Serum uric acid level was measured. The patients were followed up for incidence of DR and DN. The correlation between serum uric acid and DN was evaluated and the influencing factors of DN in patients with type 2 diabetes DR were analyzed. 【Results】 The average follow-up time was (33.2±3.1) months. No patients were lost to follow-up. A total of 23 cases (23.0%) of DN occurred, and the no-DN rate was 87.0% (87/100) in 2 years. The uric acid level in patients with DN was higher than that in patients without DN (P<0.05). Kaplan-Meier and Log-rank test showed that patients with elevated blood uric acid levels had shorter DN accumulation time than patients with reduced serum uric acid levels (P<0.05). Cox analysis showed that age, duration of diabetes, carotid atherosclerotic plaque, fundus lesions, fasting blood glucose, and uric acid were independent factors affecting DN in patients with type 2 diabetes (P<0.05). ROC analysis showed that the area under the curve uric acid to predict DN in DR patients with type 2 diabetes was 0.74, the sensitivity was 65.2% and the specificity was 78.9%.【Conclusion】 The risk of DN is significantly increased in type 2 diabetic DR patients with elevated serum uric acid level, and serum uric acid is an effective biomarker for predicting DN in patients with type 2 diabetes.
Key wordsDiabetes Mellitus/CO    Diabetic Retinopathy    Diabetic Nephropathies    Uric Acid
收稿日期: 2019-09-04     
PACS:  R587.1  
基金资助:江苏省青年医学重点人才项目(QNRC2016455)
引用本文:   
胡淑阳, 徐燕, 赵恒霞. 血尿酸水平对糖尿病视网膜病变患者发生糖尿病肾病的影响[J]. 医学临床研究, 2020, 37(8): 1148-1150.
HU Shu-yang, XU Yan, ZHAO Heng-xia. Effect of Serum Uric Acid Level on the Risk of Diabetic Nephropathy in Patients with Diabetic Retinopathy. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1148-1150.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.08.009     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I8/1148
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