医学临床研究
  2025年7月25日 星期五           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2020, Vol. 37 Issue (11): 1688-1690    DOI: 10.3969/j.issn.1671-7171.2020.11.027
  论著 本期目录 | 过刊浏览 | 高级检索 |
MHD患者Treg、Th17细胞及血清FGF23的变化与颈动脉粥样硬化的关系
潘艳子1, 张娟2
1.陕西省宝鸡市中医院肾内科,陕西 宝鸡 721001;
2.陕西省安康市中心血站成分制备科,陕西 安康 725000
Relationship of Treg, Th17 Cells and serum FGF23 with Carotid Atherosclerosis in Patients with MHD
PAN Yan-zi, ZHANG Juan
Department of Nephrology, Baoji Hospital of Traditional Chinese Medicine 721001
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的】探讨维持性血液透析(MHD)治疗患者外周血调节性T细胞(Treg)、辅助性T细胞17(Th17)及血清成纤维细胞生长因子-23(FGF23)的变化与颈动脉粥样硬化的关系。【方法】本院门诊实施MHD治疗的120例患者,均接受颈部彩色多普勒超声(CDFI)检查,根据是否发现颈动脉内膜中膜厚度(IMT)≥1.0 mm分为硬化组52例、非硬化组68例;比较两组外周血Treg、Th17细胞及血清FGF23水平,分析其与IMT的相关性。【结果】硬化组和非硬化组患者的年龄、性别、原发性疾病构成、高血脂合并率、吸烟、饮酒率组间比较差异均无显著性(P>0.05);硬化组患者的透析龄长于非硬化组(P<0.05);硬化组患者的外周血中Th17细胞、血清FGF23、颈动脉IMT测定值高于非硬化组(P<0.05);硬化组患者的Treg测定值显著低于非硬化组(P<0.05)。Pearson线性相关分析法显示MHD伴颈动脉粥样硬化患者的外周血中Th17细胞、血清FGF23测定值与IMT呈显著的正相关性(P<0.05),Treg测定值与IMT呈显著负相关性(P<0.05)。【结论】MHD患者免疫失衡及血清FGF23水平升高可能与颈动脉粥样硬化形成有一定的关系。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
潘艳子
张娟
关键词 血液透析动脉粥样硬化/并发症颈动脉疾病T淋巴细胞, 调节性T淋巴细胞亚群    
Abstract:【Objective】To investigate the relationship of peripheral blood regulatory T cells (Treg), helper T cell (Th17) and serum fibroblast growth factor-23 (FGF23) with carotid atherosclerosis in patients with maintenance hemodialysis (MHD) treatment. 【Methods】A total of 120 patients who underwent MHD received color Doppler ultrasonography (CDFI) to measure the intima-media thickness (IMT) of carotid artery. There were 52 cases belonging to the sclerotic group with IMT≥1.0 mm and 68 cases were in the non-sclerotic group. The levels of Treg, Th17 cells and serum FGF23 in the peripheral blood were compared between the two groups. The correlation between the above indicators and IMT was analyzed. 【Results】There were no significant differences in age, gender, primary disease composition, hyperlipidemia, smoking, and alcohol consumption between the sclerotic group and the non-sclerosis group (P>0.05). compared to the non-sclerotic group, patients in the sclerosis group had longer dialysis treatment (P<0.05). Levels of Th17 cells, serum FGF23, and carotid IMT of the peripheral blood in the sclerotic group were higher than those in the non-sclerotic group (P<0.05). While the Treg level in the sclerotic group was significantly lower than that in the non-sclerotic group (P<0.05). Pearson linear correlation analysis showed that the peripheral blood levels of Th17 cells and serum FGF23 in MHD patients were positive correction with IMT (P<0.05); while Treg value showed a significant negative correlation with IMT (P<0.05). 【Conclusion】Immunity imbalance and elevated serum FGF23 level in patients with MHD may be associated with carotid atherosclerosis.
Key wordsRenal Dialysis    Atherosclerosis/CO    Carotid Artery Diseases    T-Lymphocytes, Regulatory    T-Lymphocyte Subsets
收稿日期: 2019-08-12     
PACS:  R692  
通讯作者: E-mail:1097593467@qq.com   
引用本文:   
潘艳子, 张娟. MHD患者Treg、Th17细胞及血清FGF23的变化与颈动脉粥样硬化的关系[J]. 医学临床研究, 2020, 37(11): 1688-1690.
PAN Yan-zi, ZHANG Juan. Relationship of Treg, Th17 Cells and serum FGF23 with Carotid Atherosclerosis in Patients with MHD. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1688-1690.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.11.027     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I11/1688
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn