Abstract：【Objective】To explore the changes and significance of serum interleukin-6 (IL-6), calcium binding protein β (S100β), interleukin-1β (IL-1β) and interleukin-2 (IL-2) in patients with first-episode schizophrenia. 【Methods】Ninety patients with first-episode schizophrenia admitted to our hospital from March 2015 to May 2018 were divided into positive symptoms group (n=48) and negative symptoms group (n=42) according to their symptoms. Sixty healthy volunteers in the same period were selected as the control group. The serum levels of IL-6, S100β, IL-1β and IL-2 were compared among the three groups, and the relationship between serum levels of IL-6, S100beta, IL-1β and IL-2 and PANSS score was analyzed. 【Results】The serum levels of IL-6, S100β and IL-1β in the positive and negative symptoms groups were significantly higher than those in the control group, and the serum levels of IL-2 were significantly lower than those in the control group (P<0.05); the serum levels of IL-6 in the positive symptoms group and the negative symptoms group were significantly higher than those in the control group (P<0.05). The scores of positive symptoms, negative symptoms and PANSS in the positive symptoms group and negative symptoms group were significantly higher than those in the control group, and the scores of positive symptoms in the positive symptoms group were significantly higher than those in the negative symptoms group (P<0.05). There was a significant positive correlation between serum IL-1beta and PANSS total score (P<0.05). There was no significant correlation between serum IL-6, S100β and IL-2 levels and PANSS total score (P>0.05).【Conclusion】The serum levels of IL-6, S100β and IL-1β in schizophrenia patients increased significantly, while the expression of IL-2 decreased significantly. The expression of IL-1beta is closely related to the PANSS score of schizophrenia patients.
[1] 代文瑾,张媛,尚翠华,等. 急性发作精神分裂症患者血清前炎性因子与临床特征的关系[J]. 神经疾病与精神卫生,2017,17(8):558-561. [2] 王灵君,范彦蓉,张翠芳,等. 精神分裂症患者脑小胶质细胞活化理论研究进展[J]. 中国健康心理学杂志,2018,26(7):1114-1118. [3] Bener A, Dafeeah EE, Abou-Saleh MT, et al. Schizophrenia and co-morbid obsessive - compulsive disorder: Clinical characteristics[J]. Asian J Psychiat,2018,37(7):80-84. [4] Hunt GE, Large MM, Cleary M, et al. Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990–2017: Systematic review and meta-analysis[J]. Drug Alcohol Depend,2018,191(5):234-258. [5] 姚传斌,胡乃启,王志广,等. 外周血氧化应激因子、IL-6、S100-β、NT-3与精神分裂症症状的相关性研究[J]. 国际精神病学杂志,2018,45(2):237-239. [6] 朱琦玥,李雪,黑钢瑞,等. 首发精神分裂症患者血清中高迁移率族蛋白B1及细胞因子的变化分析[J]. 中华医学杂志,2015,95(47):3818-3822. [7] 王灵君,孙志刚,李军涛,等. 精神分裂症认知功能障碍的“免疫学理论”研究进展[J]. 中国健康心理学杂志,2018,26(2):308-310. [8] 曹宏波,刘忠纯. 首发精神分裂症患者血清BDNF、IL-6、Hcy水平与认知功能障碍的关系[J]. 国际检验医学杂志,2017,38(3):331-333. [9] 颜涛,程超,王会霞,等. 血清IL-6、TNF-α和IL-1β在首发精神分裂症患者中的检测及意义[J]. 海南医学院学报,2015,25(8):1106-1108.
2019, Vol. 36 
