医学临床研究
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医学临床研究  2019, Vol. 36 Issue (1): 21-24    DOI: 10.3969/j.issn.1671-7171.2019.01.007
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调强放疗联合乙酰半胱氨酸治疗非小细胞肺癌的疗效观察
卢秀荣, 宋晓, 邹念东, 张志林, 原娜, 张贤雨
河北北方学院附属第一医院放疗科,河北 张家口 075000
Clinical Study on Intensity-modulated Radiation Therapy Combined with Acetylcysteine in Treating Non-small Cell Lung Cancer
LU Xiu-rong, SONG Xiao, ZOU Nian-dong, et al
Department of Radiotherapy, First Affiliated Hospital of Hebei North University; Zhang Jiakou, Hebei 075000
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摘要 【目的】 探讨调强放疗联合乙酰半胱氨酸治疗非小细胞肺癌(NSCLC)的临床疗效。【方法】 选择2014年8月至2015年12月本院诊治的NSCLC患者80例,采用随机数表分成观察组和对照组,每组40例。对照组给予单纯调强放疗,观察组在对照组基础上联合乙酰半胱氨酸泡腾片治疗。比较两组放射性肺炎发生率和放疗前后不同时间点血清生物学指标[还原型谷胱甘肽(GSH)、白介素(IL)-6、转化生长因子(TGF)-β、Ⅱ型肺泡细胞表面抗原(KL-6)]水平、卡氏功能状态量表(KPS)评分。【结果】 观察组放射性肺炎发生率为15.00%(6/40),显著低于对照组的40.00%(16/40)(P<0.05)。观察组放疗结束时及放疗后1、3个月时血清GSH水平均显著高于对照组同时间点,血清IL-6、TGF-β、KL-6浓度均显著低于对照组同时间点(P<0.05)。观察组放疗结束时和放疗后1、3个月时KPS评分与对照组同时间点相比均显著增加(P<0.05)。【结论】 采用调强放疗联合乙酰半胱氨酸治疗NSCLC,可减少放射性肺炎的发生率,增强机体抗氧化能力,提高患者生活质量。
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关键词 肺肿瘤/放射疗法药用制剂    
Abstract【Objective】 To explore the clinical efficacy of intensity-modulated radiation therapy combined with acetylcysteine in the treatment of non-small cell lung cancer (NSCLC).【Methods】 In this study, a total of 80 patients with NSCLC admitted in our hospital from August 2014 to December 2015, were divided into two groups on the basis of random number table method, with 40 cases in each group. The control group was administrated with solely intensity-modulated radiation therapy, while the treatment group was administrated with intensity-modulated radiation therapy in combination with acetylcysteine. The incidence of radiation pneumonitis, changes of serum biological markers [glutathione (GSH), interleukin (IL) -6, transforming growth factor (TGF) -β, type II alveolar cell surface antigen (KL-6)], and Karnofsky performance status (KPS) scores at different time points before and after the therapy were compared between the two groups.【Results】 The incidence of radiation pneumonitis in the treatment group was 15.00% (6/40), which was significantly lower than that in the control group 40.00% (16/40)(P<0.05). The serum GSH levels in the observation group at the end of radiotherapy and 1 and 3 months after radiotherapy were significantly higher than those in the control group. The serum levels of IL-6, TGF-β and KL-6 were significantly lower than those in the control group (P<0.05). The KPS scores at the end of radiotherapy and 1 and 3 months after radiotherapy were significantly increased in the observation group compared with the control group (P<0.05).【Conclusion】 In the treatment of NSCLC, the combination of intensity modulated radiation therapy and acetylcysteine proves to be effective in preventing radiation pneumonitis, enhancing body's antioxidation capacity, reducing the irradiation-induced lung injury and improving life quality.
Key wordsLung Neoplasms/RT    Pharmaceutical Preparations
收稿日期: 2018-07-10     
PACS:  R734.2  
基金资助:张家口市2014年度科学技术研究与发展计划(编号:1421151D)
引用本文:   
卢秀荣, 宋晓, 邹念东, 张志林, 原娜, 张贤雨. 调强放疗联合乙酰半胱氨酸治疗非小细胞肺癌的疗效观察[J]. 医学临床研究, 2019, 36(1): 21-24.
LU Xiu-rong, SONG Xiao, ZOU Nian-dong, et al. Clinical Study on Intensity-modulated Radiation Therapy Combined with Acetylcysteine in Treating Non-small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(1): 21-24.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.01.007     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I1/21
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