Abstract：【Objective】 To explore the correlation between prognosis and levels of serum carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and β2-microglobulin(β2-MG) in bladder cancer patients.【Methods】 The serum levels of CEA, CA19-9, and β2-MG were measured in 106 bladder cancer patients(the observation group) and 85 healthy individuals(the control group). The relationship between these markers and prognosis as well as the risk factors for death in bladder cancer patients were analyzed.【Results】 The levels of CEA, CA19-9, and β2-MG in the observation group were higher than those in the control group. Furthermore, the preoperative levels of these markers in the observation group were higher than their postoperative levels(all P<0.05). During a 36-month follow-up, 63 of the 106 bladder cancer patients survived(the survival group), while 43 died(the death group). The death group had a higher proportion of patients in TNM stages Ⅲ-Ⅳ and poorly differentiated tumors, as well as higher expression levels of CEA, CA19-9, and β2-MG compared to the survival group(P<0.05). Logistic multivariate regression analysis revealed that TNM stages Ⅲ-Ⅳ, poorly differentiated tumors, and high expression of CEA, CA19-9, and β2-MG were significant risk factors for death in bladder cancer patients(P<0.05). The 3-year survival rate in the high expression groups of CEA, CA19-9, and β2-MG was significantly lower than that in the low expression groups(P<0.05).【Conclusion】 Serum levels of CEA, CA19-9, and β2-MG are closely related to the prognosis of bladder cancer patients. These markers can serve as independent prognostic indicators for bladder cancer.
2026, Vol. 43 
