Abstract：【Objective】To investigate the diagnostic value of combined detection of C-reactive protein (CRP), soluble cluster of differentiation 14 subtype (sCD14-ST) and neutrophil alkaline phosphatase (NAP) in children with respiratory tract infections. 【Methods】A total of 50 children with respiratory tract infections (as observation group) and 50 healthy children with health examination (as control group) in our hospital were selected for the study. Serum CRP, sCD14-ST levels and NAP scores were compared between the two groups, and the scores of CRP, sCD14-ST and NAP were also analyzed in sick children infected by different pathogens. The correlation among CRP,sCD14-ST and NAP was analyzed, and the diagnostic efficacy of CPR, sCD14-ST and NAP for respiratory infection was compared as well. 【Results】The serum CRP, sCD14-ST levels and NAP scores in the observation group were significantly higher than those in the control group (P<0.05). Serum CRP, sCD14-ST levels and NAP scores were significantly different in children with respiratory tract infection caused by different pathogens (P<0.05). The levels of serum CRP, sCD14-ST and NAP scores of children with bacterial respiratory infections were significantly higher than those of children with viral and mycoplasma respiratory tract infections, and the difference was significant (P<0.05). And serum CRP, sCD14-ST and NAP levels of children with viral respiratory tract infections were significantly higher than those of children with mycoplasma infection (P<0.05). The results showed that CRP was positively correlated with sCD14-ST and NAP (P<0.05), moreover, sCD14-ST was positively correlated with NAP (P<0.05). CRP, sCD14-ST and NAP were independent risk factors for respiratory infection (P<0.05); The diagnostic efficacy of combined detection of the three for respiratory tract infection was significantly better than that of individual detection (P<0.05). 【Conclusion】Serum CRP, sCD14-ST levels and NAP scores are significantly elevated in children with respiratory tract infections. The combined detection of the three can improve the diagnosis efficacy.
刘平定, 杨芳谊. CRP、sCD14-ST、NAP联合检测对小儿呼吸道感染性疾病的诊断价值[J]. 医学临床研究, 2021, 38(11): 1601-1603.
LIU Ping-ding, YANG Fang-yi. Diagnostic Value of Combined Detection of CRP, sCD14-ST and NAP in Children with Respiratory Tract Infectious Diseases. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1601-1603.
[1] 刘孝桥, 涂睿. 不同病原体致小儿呼吸道感染后WBC CRP及PCT的临床研究[J].河北医学, 2017,2(4):124-128. [2] 刘娟. 维生素A缺乏、炎症因子与小儿呼吸道感染的相关性研究[J].临床肺科杂志, 2018,23(3):333-334. [3] 苏恒学. WBC、DC、NAP、CRP联合检测在中晚期肿瘤患者细菌感染中的应用价值分析[J].中外医学研究, 2015,10(14):66-67. [4] 王薇, 孙雪, 赵鸿斌. 反复呼吸道感染儿童血CRP、免疫球蛋白和T细胞亚群的相关研究[J].河北医药, 2018, 40(10):16-19. [5] BAY-JENSEN A C , PLATT A , JENKINS M A , et al. Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis[J].BMC Rheumatol,2019, 3:3. [6] MAZIDI M . Treatment with GLP1 receptor agonist reduces serum CRP concentrations in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials[J].J Diabetes Complications,2017, 31(7):1237-1242. [7] PALMIERE C, MUSSAP M, BARDY D, et al. Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities[J].Int J Legal Med,2013, 127(4):799-808. [8] CHENEVIERGOBEAUX C, BARDET V, POUPET H, et al.Presepsin (sCD14-ST) secretion and kinetics by peripheral blood mononuclear cells and monocytic THP-1 cell line[J].Ann Biol Clin,2016, 74(1):93-97. [9] LI H, ZHAO Y, LI W, et al. Critical role of neutrophil alkaline phosphatase in the antimicrobial function of neutrophils[J].Life Sci,2016, 157(1):152-157.
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