医学临床研究
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医学临床研究  2020, Vol. 37 Issue (9): 1333-1335    DOI: 10.3969/j.issn.1671-7171.2020.09.017
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陈旧性腔隙性脑梗死对初发脑梗死患者预后判断的影响
蔡瑞煜, 王海萍, 白蓓蓓
青岛大学附属医院,山东 青岛 266000
Effect of Old Lacunar Infarction on Prognosis of Patients with Primary Cerebral Infarction
CAI Rui-yu, WAHG Hai-ping, BAI Bei-bei
The Affiliated Hospital of Qingdao,Qingdao,shandong,266000
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摘要 【目的】 探讨陈旧性腔隙性脑梗死(LI)对初发脑梗死患者预后判断的影响。【方法】 回顾性分析本院收治的145例存在陈旧性LI病史的初发脑梗死患者的临床资料。根据陈旧性LI情况病灶的数目分为A组(病灶≤4个)、B组(病灶>4个)。比较两组脑微出血分级、脑白质病变程度分级、颅内动脉钙化评分。对影响患者预后的因素进行回归分析。【结果】 与A组比较,B组患者中3级脑微出血的比例明显增多(P<0.05),2、3级脑白质病变的比例明显增多(P<0.05),颅内动脉钙化评分3分以上的比例明显增多(P<0.05),Spearman分析显示陈旧性LI病灶数目与脑微出血分级程度、脑白质病变程度和颅内动脉钙化评分呈正相关(Rs=0.735,0.774,0.695,P<0.05)。多因素COX回顾分析显示:陈旧性LI病灶数目、脑微出血分级、脑白质病变程度分级、颅内动脉钙化评分、出院后未使用抗血小板药、出院后未使用他汀类药物是初发脑梗死患者预后的独立危险因素(P<0.05)。【结论】 陈旧性LI病灶数目与脑微血管病变、脑白质病变程度和颅内动脉钙化评分密切相关,且都是初发脑梗死患者预后的独立危险因素。
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蔡瑞煜
王海萍
白蓓蓓
关键词 脑梗死预后    
Abstract【Objective】 To investigate the effect of old lacunar infarction (LI) on the prognosis of patients with primary cerebral infarction. 【Methods】 The clinical data of 145 patients with primary cerebral infarction with old LI history were retrospectively analyzed. According to the number of old Li, the patients were divided into group A (lesions≤4) and group B (lesions > 4). The grade of cerebral microbleeds, white matter lesions and intracranial artery calcification were compared between the two groups. The factors influencing the prognosis were analyzed by regression analysis.【Results】 Compared with the group A, the proportion of grade 3 cerebral microbleeds in the group B was significantly increased (P<0.05), the proportion of grade 2 and 3 white matter lesions was significantly increased (P<0.05), and the proportion of intracranial artery calcification score above 3 points was significantly increased (P<0.05). Spearman analysis showed that the number of old LI lesions was positively correlated with the grade of cerebral microbleeds, the degree of white matter lesions and the score of intracranial artery calcification (Rs=0.735,0.774,0.695,P<0.05). Multivariate COX regression analysis showed that the number of old LI lesions, grade of cerebral microbleeds, grade of white matter lesions, intracranial artery calcification score, no use of antiplatelet drugs after discharge and no use of statins were independent risk factors for the prognosis of patients with primary cerebral infarction (P<0.05).【Conclusion】 The number of old LI lesions is closely related to cerebral microvascular lesions, white matter lesions and intracranial artery calcification score, and are independent risk factors for the prognosis of patients with initial cerebral infarction
Key wordsBrain Infarction    Prognosis
收稿日期: 2019-09-07     
PACS:  R743.33  
引用本文:   
蔡瑞煜, 王海萍, 白蓓蓓. 陈旧性腔隙性脑梗死对初发脑梗死患者预后判断的影响[J]. 医学临床研究, 2020, 37(9): 1333-1335.
CAI Rui-yu, WAHG Hai-ping, BAI Bei-bei. Effect of Old Lacunar Infarction on Prognosis of Patients with Primary Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2020, 37(9): 1333-1335.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.09.017     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I9/1333
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