Abstract：【Objective】 To compare the effects of different sedation strategies on the levels of myocardial injury markers and prognosis in patients with sepsis myocardial injury. 【Methods】 A total of 72 patients with sepsis who met the criteria were randomly divided into two groups, i.e. the light sedation group and the deep sedation group, with 36 cases in each group. Patients in the light sedation group had RASS score (0～-2 points),whilepatients in the deep sedation group had RASS score (-3～-4 points). All patients were sedated with propofol. The values of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and troponin T (cTnT) in the two groups were compared between the first day to the third day after sedation.【Results】 The levels of BNP (pg/mL) gradually decreased from day 1 to day 3 in both groups.The differences between the groups were statistically significant (P<0.05).The levels of cTnT and cTnI decreased slowly from day 1 to day 3 in both groups, however, the difference was not statistically significant (P>0.05).The mechanical ventilation time and ICU stay time were compared between the two groups. The differences between the two groups were statistically significant (P<0.05).There was no significant difference in terms of 28-day case-fatality rates between the groups (P>0.05). 【Conclusion】 The Deep sedation has a stronger myocardial protection effect in patients with sepsis myocardial injury, while the light sedation can shorten the patient's mechanical ventilation time and reduce the patient's ICU hospitalization time. However, both can't change patients' 28-day case-fatality rates.
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2020, Vol. 37 
