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Quick Search     Adv Search 2024 Vol. 41, No. 8 Published: 2024-08-26 Original Articles          Original Articles 1121 Predictive Value of Uterine Artery Pulse Index Combined with Serum β-HCG Level in Late-Onset Fetal Intrauterine Growth Restriction in the Second Trimester LI Xina, XU Ning, WANG Fuli DOI: 10.3969/j.issn.1671-7171.2024.08.001 【Objective】To investigate the value of uterine artery pulsation index (PI) combined with serum β-subunit human chorionic gonadotropin (β-HCG) level in predicting intrauterine growth restriction in late-onset fetuses during the second trimester. 【Methods】A total of 179 pregnant women were selected from Xi'an People's Hospital(Xi'an Fourth Hospital) from January 2019 to December 2023. According to the occurrence of growth restriction, they were divided into the late-onset intrauterine growth restriction group and non-late-onset intrauterine growth restriction group. PI and β-HCG were measured during the second trimester. Logistic regression was used to analyze the risk factors of intrauterine growth restriction in late-onset fetuses. We also analyzed the value of uterine artery ultrasound PI combined with β-HCG in predicting late-onset fetal intrauterine growth restriction in the second trimester. 【Results】There were 31 cases of late-onset intrauterine growth restriction (17.32%) in pregnant women, which were classified as late-onset intrauterine growth restriction group and 148 cases of non-late-onset intrauterine growth restriction group. There was no statistical significance in age, gestational time, family history of hypertension during pregnancy, systolic blood pressure, TC and albumin between late and non-late intrauterine growth restriction group (P>0.05). The levels of PI, β-HCG and gestational age in the late intrauterine growth restriction group were higher than those in the non-late intrauterine growth restriction group (P<0.05). The occurrence of late-onset fetal intrauterine growth restriction was taken as the dependent variable, and PI and β-HCG were taken as independent variables for Logistic multivariate regression analysis (assignment: PI and β-HCG levels were continuous variables), the results showed that PI and β-HCG were risk factors for late-onset intrauterine growth restriction (P<0.05). ROC curve results showed that the AUC value of PI combined with β-HCG in predicting late-onset intrauterine growth restriction was 0.937, which was higher than that predicted alone (P<0.05). 【Conclusion】Both PI and β-HCG are closely related to intrauterine growth restriction of late-onset fetuses, and they can be used to predict intrauterine growth restriction of late-onset fetuses, while the prediction efficiency of PI and β-HCG combined value is higher than either PI or β-HCG alone. 2024 Vol. 41 (8): 1121-1123 [Abstract] ( 71 ) HTML (1 KB)  PDF (1289 KB)  ( 63 ) 1124 Relationship of Serum Levels of CRP, Hcy, and MMP-9 with Concurrent Pneumonia in Elderly Patients with Multiple Cerebral Infarctions ZHAI Junge, ZUO Yanyan, XIN Huiqin DOI: 10.3969/j.issn.1671-7171.2024.08.002 【Objective】To explore the relationship of serum levels of C-reactive protein (CRP), homocysteine (Hcy), and matrix metalloproteinase-9 (MMP-9) with the occurrence of concurrent pneumonia in elderly patients with multiple cerebral infarctions .【Methods】The clinical data of 80 elderly patients with multiple cerebral infarctions were retrospectively analyzed. The patients were divided into two groups based on whether they had hospital-acquired pneumonia: the concurrent pneumonia group (n=18) and the non-concurrent pneumonia group (n=62). General data and serum levels of CRP, Hcy, and MMP-9 were compared between the two groups. The value of CRP, Hcy, and MMP-9 levels in predicting concurrent pneumonia was analyzed using receiver operating characteristic (ROC) curves. Multivariate Logistic regression analysis was applied to identify risk factors for concurrent pneumonia. 【Results】 The proportion of patients aged ≥70 years and those with a history of pulmonary disease was significantly higher in the concurrent pneumonia group than in the non-concurrent pneumonia group (P<0.05). The levels of CRP, Hcy, and MMP-9 were significantly higher in the concurrent pneumonia group compared to the non-concurrent pneumonia group (P<0.05). ROC and Logistic analysis showed that the area under the curve (AUC) values of CRP, Hcy, and MMP-9 in predicting concurrent pneumonia were 0.834, 0.850, and 0.752, respectively (P<0.05). Age ≥70 years, a history of pulmonary disease, CRP ≥21.725 mg/L, Hcy ≥21.420 μmol/L, and MMP-9 ≥385.255 ng/mL were identified as risk factors for concurrent pneumonia (P<0.05).【Conclusion】 Monitoring serum levels of CRP, Hcy, and MMP-9 has predictive value for concurrent pneumonia in elderly patients with multiple cerebral infarctions. 2024 Vol. 41 (8): 1124-1127 [Abstract] ( 48 ) HTML (1 KB)  PDF (1237 KB)  ( 57 ) 1128 The Effects of Different Femoral Osteotomy Methods on the Complications and Hip Joint Function of Total Hip Replacement for Developmental Dysplasia of the Hip MA Chunhui, SUN Ningning, ZHANG Xiaoying, et al DOI: 10.3969/j.issn.1671-7171.2024.08.003 【Objective】To investigate the effects of different femoral osteotomy methods on the complications and hip joint function of total hip replacement (THR) for developmental dysplasia of the hip (DDH). 【Methods】A total of 95 DDH patients who underwent THR treatment in our hospital from January 2021 to October 2022 were selected and divided into three groups according to different osteotomy methods: Group A [using short and shortened trochanter osteotomy (SSO), n=32], Group B [using extended trochanter osteotomy (ETO), n=32], and Group C (using large trochanter long oblique osteotomy, n=31). The surgical related indicators, hip joint function scores, and incidence of complications were compared among the three groups.【Results】The results showed that the operation time of Group C was shorter than that of Group A and Group B, and the total bleeding volume was less than that of Group A and Group B, with statistically significant differences (P<0.05). At 1 week, 1 month, and 3 months after surgery, the hip joint function scores of Group C were higher than those of Group A and Group B (P<0.05). The healing time of the osteotomy site and the difference in lower limb length one year after surgery in Group C were less than those in Group A and Group B (P<0.05); One week after surgery, the pain level in Group C was lower than that in Group A and Group B (P<0.05). There was no statistically significant difference in the incidence of complications among the three groups (P>0.05). 【Conclusion】 The use of different femoral osteotomy methods for THR treatment in DDH patients can effectively improve hip joint function and reduce the incidence of complications. However, the use of a large trochanter long oblique osteotomy method can significantly shorten the surgical time, reduce total bleeding, and promote patient recovery. 2024 Vol. 41 (8): 1128-1131 [Abstract] ( 45 ) HTML (1 KB)  PDF (1178 KB)  ( 39 ) 1132 The Impact of Different Doses of Febuxostat on the Micro-Inflammatory State in Patients with Stage 3-5 Chronic Kidney Disease and Hyperuricemia Undergoing Maintenance Hemodialysis LIU Qiong, HUA Qi, ZHOU Yun DOI: 10.3969/j.issn.1671-7171.2024.08.004 【Objective】To investigate the effects of different doses of febuxostat on the micro-inflammatory state in patients with stage 3-5 chronic kidney disease (CKD) accompanied by hyperuricemia undergoing maintenance hemodialysis (MHD). 【Methods】A total of 114 patients undergoing MHD with stage 3-5 CKD and hyperuricemia were randomly divided into three groups: Group A (38 patients), treated with 40 mg/day of oral febuxostat; Group B (38 patients), treated with 80 mg/d of oral febuxostat; and Group C (38 patients), treated with 300 mg/d of oral allopurinol. After 24 weeks of treatment, the clinical efficacy, serum markers, and adverse drug reactions during the treatment period were compared among the three groups. 【Results】There were no statistically significant differences in clinical efficacy among the three groups (P>0.05). After treatment, the levels of serum uric acid, endothelin-1 (ET-1), interleukin-10 (IL-10), and neutrophil elastase (NE) decreased in all groups (P<0.05), but there were no statistically significant differences between the groups (P>0.05). The incidence of adverse reactions was also not significantly different among the groups (P>0.05). 【Conclusion】Different doses of febuxostat in patients undergoing MHD with stage 3-5 CKD and hyperuricemia can improve the micro-inflammatory state and reduce serum uric acid levels, with good efficacy and safety. Clinical treatment should be tailored to the specific circumstances of the patient. 2024 Vol. 41 (8): 1132-1134 [Abstract] ( 39 ) HTML (1 KB)  PDF (1160 KB)  ( 64 ) 1135 Effect of Non-Insufflated and Insufflated Transaxillary Endoscopic Thyroidectomy on Recurrent Laryngeal Nerve Injury and Prognosis in Patients with Differentiated Thyroid Carcinoma CHEN Yalin, WANG Xiaobin, WANG Jing, et al DOI: 10.3969/j.issn.1671-7171.2024.08.005 【Objective】 To investigate the effect of non-insufflated and insufflated transaxillary endoscopic thyroidectomy on recurrent laryngeal nerve (RLN) injury and prognosis in patients with differentiated thyroid carcinoma (DTC).【Methods】 Eighty-eight DTC patients undergoing transaxillary endoscopic thyroidectomy in our hospital were divided into a non-insufflated group (40 cases) and an insufflated group (48 cases) according to the different surgical methods. The levels of parathyroid hormone (PTH), recurrence rate, operation time, hospital stay, blood loss, drainage volume, incidence of RLN injury, and quality of life (QOL) scores were compared between the two groups.【Results】 Postoperatively, the PTH level in the non-insufflated group was higher than that in the insufflated group (P<0.05). There was no statistically significant difference in the recurrence rates between the two groups (P>0.05). The operation time and hospital stay were shorter, and the blood loss and drainage volume were less in the non-insufflated group than in the insufflated group. The incidence of temporary RLN injury was lower in the non-insufflated group (P<0.05). At three months post-operation, the QOL scores in the non-insufflated group were higher than those in the insufflated group (P<0.05).【Conclusion】 Compared to insufflated surgery, non-insufflated transaxillary endoscopic thyroidectomy can shorten the operation and hospital stay, reduce blood loss and drainage volume, and lower the incidence of temporary RLN injury. Additionally, patients have better quality of life postoperatively, making it worthy of clinical promotion and application. 2024 Vol. 41 (8): 1135-1137 [Abstract] ( 76 ) HTML (1 KB)  PDF (1215 KB)  ( 32 ) 1138 Application Value of Combined Detection of cTnT, cys C, and NT-proBNP in Diagnosing Heart Failure Patients SUN Xiaolan, CHEN Min, JIANG Danma DOI: 10.3969/j.issn.1671-7171.2024.08.006 【Objective】To explore the clinical value of combined detection of serum cardiac troponin T (cTnT), cystatin C (cys C), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the diagnostic process of heart failure patients.【Methods】 Fifty heart failure patients treated in our hospital were selected as the observation group, and 40 healthy individuals undergoing physical examination during the same period were selected as the control group. The levels of cTnT, cys C, and NT-proBNP were compared between the two groups. The levels of cTnT, cys C, and NT-proBNP were also compared among patients with different grades of cardiac function in the observation group, as well as the changes in these indicators before and after treatment in the patients.【Results】 The levels of cTnT, cys C, and NT-proBNP at admission in the observation group were significantly higher than those in the control group, with statistically significant differences (P<0.05). Among the 50 heart failure patients, the levels of cTnT, cys C, and NT-proBNP decreased from cardiac function grade Ⅳ to grade Ⅱ, with statistically significant differences between patients of different grades (P<0.05). The levels of cTnT, cys C, and NT-proBNP at discharge after treatment in the observation group were significantly lower than those before treatment (P<0.05).【Conclusion】 Combined detection of cTnT, cys C, and NT-proBNP has diagnostic value in the process of diagnosing heart failure patients and is also important for evaluating the prognosis of heart failure treatment. 2024 Vol. 41 (8): 1138-1140 [Abstract] ( 37 ) HTML (1 KB)  PDF (1161 KB)  ( 18 ) 1141 Evaluation of Risk Factors for Stent Patency in Patients with Lower Limb Deep Vein Thrombosis Post Interventional Syndrome Using a Risk Column Chart Model QI Yongle, LIU Juanfang, YUAN Huifeng DOI: 10.3969/j.issn.1671-7171.2024.08.007 【Objective】 To explore the risk factors for assessing stent patency in patients with deep vein thrombosis syndrome (PTS) after interventional procedures using a risk column chart model. 【Methods】 A total of 108 PTS patients who underwent iliac femoral vein balloon dilation combined with stent implantation in both hospitals from October 2019 to June 2022. Based on the stent patency during a 2-year follow-up, they were divided into a patency group (n=90) and a non patency group (n=18). Using logistic regression analysis to identify factors affecting postoperative stent patency, a column chart prediction model was established based on the results, and validated using calibration curves. 【Results】 There was a statistically significant difference in BMI(P<0.05), antiplatelet therapy, stent number, thrombus blockage location, and elastic sock support treatment between the two groups(P<0.05). Logistic multiple regression analysis showed that high BMI, lack of standardized antiplatelet therapy, number of stents ≥2, and non use of elastic stockings were risk factors affecting stent patency in PTS patients after intervention (P<0.05). The column chart model results showed that PTS patients with high BMI, no standardized antiplatelet therapy, number of stents ≥2, and no use of elastic stockings had a higher risk of stent patency after intervention. The decision curve results showed that when the risk threshold was between 0.2 and 0.8, the Nomogram curve was higher than the All and None curves, indicating that there was the maximum net benefit when the risk threshold was between 0.2 and 0.8. 【Conclusion】PTS patients with high BMI, lack of standardized antiplatelet therapy, ≥2 stents, and no use of elastic stockings have a higher risk of stent patency after intervention. 2024 Vol. 41 (8): 1141-1143 [Abstract] ( 27 ) HTML (1 KB)  PDF (1287 KB)  ( 63 ) 1144 Comparison of the Therapeutic Effects of Endoscopic Transnasal Submucosal Approach and Traditional Transnasal Transsphenoidal Approach for Pituitary Adenoma Resection TAN Bin, CHEN Ao, YANG Fan, et al DOI: 10.3969/j.issn.1671-7171.2024.08.008 【Objective】To compare the clinical outcomes of endoscopic transnasal submucosal approach and traditional transnasal transsphenoidal approach for pituitary adenoma resection. 【Methods】A retrospective analysis was conducted on the clinical data of 85 patients with pituitary adenomas admitted to our hospital from March 2019 to April 2024. According to the surgical approach plan, they were divided into a nasal septum submucosal group (transnasal septum submucosal approach, n=45) and a nasal butterfly group (transnasal butterfly approach, n=40). The incidence of postoperative complications, olfactory function, nasal ventilation function, and hormone levels before and after surgery were compared between the two groups. 【Results】There was no statistically significant difference in the total effective rate between the two groups of patients (P>0.05). The intraoperative tumor resection rate and cerebrospinal fluid leakage rate in the submucosal group of the nasal septum were not significantly different from those in the nasal butterfly group (P>0.05); The operation time and bleeding volume of the submucosal group of the nasal septum were lower than those of the nasal butterfly group, and the difference was statistically significant (P<0.05). Compared with preoperative values, the olfactory recognition thresholds of the two groups were higher at 1 month, 3 months, and 6 months after surgery, and the nasal septum submucosal group was lower than the nasal butterfly group, with statistical significance (P<0.05). At 3 and 6 months after surgery, the nasal inspiratory and expiratory resistance in both groups were higher than before surgery, and the submucosal group of the nasal septum was lower than the nasal butterfly group, with a statistically significant difference (P<0.05). Six months after surgery, the levels of serum prolactin, growth hormone, and adrenocorticotropic hormone in both groups were lower than before surgery (P<0.05), but there was no significant difference in these indicators between the two groups at six months after surgery (P>0.05). The total incidence of postoperative complications in the submucosal group of the nasal septum was lower than that in the nasal butterfly group, and the difference was statistically significant (P<0.05). 【Conclusion】Neuroendoscopic transnasal submucosal approach for pituitary adenoma resection has minimal damage to the patient's olfactory function, low incidence of postoperative complications, and high clinical significance. 2024 Vol. 41 (8): 1144-1147 [Abstract] ( 32 ) HTML (1 KB)  PDF (1186 KB)  ( 69 ) 1148 Construction and Validation of Prediction Model for Poor Prognosis after Total Hip Replacement in Older Adult Patients YI Xinming, WAN Shunxin, ZHANG Jie, et al DOI: 10.3969/j.issn.1671-7171.2024.08.009 【Objective】To establish and validate a prediction model for poor prognosis after total hip replacement in older adult patients. 【Methods】A total of 85 elderly patients who underwent hip arthroplasty from February 2019 to July 2022 were selected. After 1 year follow-up, patients were divided into the poor prognosis group and the good prognosis group according to the prognosis of older adult patients after hip arthroplasty. By comparing the clinical data of the two groups, the influencing factors of the poor prognosis after total hip replacement in elderly patients were analyzed by binary Logistic regression method, the prediction model of the poor prognosis after total hip replacement in older adult patients was constructed by Logistic method, and the fitting degree was evaluated by Hosmer-Lemeshow test. Receiver operating characteristic curve (ROC) was plotted to evaluate the prediction model differentiation. 【Results】After 1 year of follow-up, 2 cases of the 85 patients were lost to follow-up, the follow-up rate was 97.65%. Among them, 22 patients had poor prognosis, the incidence of poor prognosis was 26.51%(22/83). The surgical severity score (P-POSSUM score) ≥15 points, rehabilitation intervention time of 7 days after surgery, bone density <-3 SD, controlled nutritional status (CONUT) score ≥5 points, monocyte-to-lymphocyte ratio (MLR) ≥1.13, and bone alkaline phosphatase (BLAP) and thyroid hormone (PTH) levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).Binary Logistic regression analysis showed that P-POSSUM score, rehabilitation intervention time, bone mineral density, CONUT score and MLR were the influencing factors for poor prognosis after total hip replacement in older adult patients (P<0.05). Taking the above influencing factors as predictive variables, a nomogram prediction model was established. The total score of each factor ranged from 76 to 426, and the corresponding risk rate ranged from 0.05 to 0.80. The C-index of the nomogram model was 0.825, and the correction curve for predicting the risk of poor prognosis after total hip replacement in older adult patients was close to the ideal curve (P>0.05). ROC curve results showed that the sensitivity and specificity of the nomogram model in predicting total poor prognosis after hip replacement in older adult patients were 90.91% and 88.52%, respectively. The area under the curve (AUC) was 0.903. 【Conclusion】P-POSSUM score, rehabilitation intervention time, bone mineral density, CONUT score and MLR are associated with the risk of poor prognosis after total hip arthroplasty in older adult patients. The construction of a nomogram model is helpful for early screening of the risk of poor prognosis after total hip arthroplasty in older adult patients. 2024 Vol. 41 (8): 1148-1151 [Abstract] ( 38 ) HTML (1 KB)  PDF (1496 KB)  ( 17 ) 1152 Clinical Efficacy of Phase Controlled Radiofrequency Microneedle Combined with Minocycline for the Treatment of Moderate to Severe Acne GUO Min, GAO Ming, LI Wenlu DOI: 10.3969/j.issn.1671-7171.2024.08.010 【Objective】To investigate the clinical efficacy of phased radiofrequency microneedling combined with minocycline in the treatment of moderate to severe acne. 【Methods】Sixty patients with moderate to severe acne who visited our clinic from July 2022 to December 2023 were randomly divided into the observation group (treated with phased radiofrequency microneedle combined with minocycline) and the control group (treated with intense pulsed light combined with minocycline) using a random number table method, with 30 patients in each group. The observation group was treated with phase controlled radiofrequency microneedle combined with minocycline, while the control group was treated with intense pulsed light combined with minocycline. Both groups received single treatment. We compared the scores of the Global Acne Grading System (GAGS) and the conditions of erythema, pores, and amethyst between two groups before treatment, 1 month after treatment, and 3 months after treatment. We also compared the treatment efficacy and incidence of adverse reactions between the two groups.【Results】One month after treatment, the effective rate of the observation group was 93.33%, which was not significantly different from the control group's 86.67% (P>0.05). After treatment, the GAGS scores of both groups decreased compared to before treatment, and the GAGS score of the observation group was lower than that of the control group (P<0.05). After treatment, both groups showed significant improvement in erythema, purple pigment, and pores compared to before treatment (P<0.05); And the improvement of erythema and pores in the observation group was better than that in the control group (P<0.05), but there was no statistically significant difference in the percentage of purple matter between the two groups (P>0.05). All patients had no significant adverse reactions. 【Conclusion】The combination of phase controlled radiofrequency microneedles or intense pulsed light with minocycline is safe and effective in treating moderate to severe acne vulgaris. However, the combination of phase controlled radiofrequency microneedles and minocycline has a more significant improvement in enlarged pores and fine skin texture. 2024 Vol. 41 (8): 1152-1155 [Abstract] ( 35 ) HTML (1 KB)  PDF (1185 KB)  ( 35 ) 1156 Application Effect of Autogenous Dentin Particles Combined with Nd: YAG Laser in Patients with Anterior Periodontitis after Tooth Extraction Surgery REN Wenping, SUN Yuanzheng, ZHANG Wenjing DOI: 10.3969/j.issn.1671-7171.2024.08.011 【Objective】To investigate the application effect of autogenous dentin particles combined with Nd: YAG laser in patients with anterior periodontitis after tooth extraction.【Methods】A total of 123 patients with anterior periodontitis who underwent tooth extraction surgery in our hospital from May 2021 to March 2023 were selected and divided into the observation group (n=63, 63 teeth) and the control group (n=60, 60 teeth) according to different treatment methods. The control group was treated with Nd: YAG laser, while the observation group was treated with autogenous dentin particles in addition to the control group. The treatment effects of the two groups were compared.【Results】One year after treatment, the success rate of implantation in the observation group was significantly higher than that in the control group (P<0.05), but there was no statistically significant difference in aesthetic effects between the two groups (P>0.05); After 7 days of treatment, the pain levels in both groups decreased, and the observation group was lower than the control group (P>0.05). One year after treatment, the plaque index (PLI), bleeding index (SBI), gingival index (GI), and periodontal pocket depth (PD) in both groups decreased (P<0.05), and the PLI, SBI, GI, and PD in the observation group were lower than those in the control group. The total incidence of complications in the observation group was significantly lower than that in the control group (χ2=0.230, P=0.631). 【Conclusion】 The application of autogenous dentin particles combined with Nd: YAG laser in patients with anterior periodontitis after tooth extraction can significantly improve chewing efficiency, aesthetic effects, and periodontal function, with a low incidence of complications. It is worthy of clinical promotion and application. 2024 Vol. 41 (8): 1156-1159 [Abstract] ( 33 ) HTML (1 KB)  PDF (1474 KB)  ( 138 ) 1160 The Correlation between EGFR and Ki-67 Expression and the Prognosis of Radical Surgery for Primary Liver Cancer WANG Xiaojian DOI: 10.3969/j.issn.1671-7171.2024.08.012 【Objective】To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and Ki-67 in cancer tissues and the postoperative prognosis of primary liver cancer (HCC).【Methods】A total of 103 HCC patients admitted to the hospital from June 2015 to June 2018 were selected. All patients underwent HCC radical surgery and postoperative prophylactic transcatheter arterial chemoembolization, and were followed up for 3 years after surgery. We detected and compared the expression of EGFR and Ki-67 in cancer tissues and adjacent tissues, analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and pathological factors, analyzed the factors affecting the prognosis of HCC radical surgery, and analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and postoperative prognosis of HCC.【Results】The positive expression rates of EGFR and Ki-67 in cancer tissues were higher than those in adjacent tissues (P<0.05). The positive expression rates of EGFR and Ki-67 in cancer tissues of patients with microvascular tumor thrombus, incomplete tumor capsule, clinical stage Ⅲ, and low differentiation were higher than those of patients without microvascular tumor thrombus, intact tumor capsule, clinical stage Ⅰ-Ⅱ, and moderately to well differentiated patients (P<0.05). Cox regression analysis showed that microvascular tumor thrombus, tumor capsule, clinical stage, differentiation degree, EGFR expression, Ki-67 expression were related factors affecting disease-free survival rate (P<0.05); Tumor capsule, clinical stage, differentiation degree, EGFR expression, and Ki-67 expression are related factors affecting overall survival rate (P<0.05). The disease-free survival rate and overall survival rate of EGFR and Ki-67 negative expression patients were better than those of positive expression patients, and the differences were statistically significant (P<0.05).【Conclusion】EGFR and Ki-67 are abnormally overexpressed in cancer tissues of HCC patients. EGFR and Ki-67 expression are associated with the pathology and prognosis of HCC patients after surgery, and those with positive expression have a higher risk of poor prognosis. 2024 Vol. 41 (8): 1160-1163 [Abstract] ( 38 ) HTML (1 KB)  PDF (1186 KB)  ( 56 ) 1164 The Effect of Ezetimibe on Cardiac Function and PI3K/AKT/GSK3 β Signaling Pathway after Acute Myocardial Infarction in Hyperlipidemic Rats YAN Yunpeng, WANG Miao DOI: 10.3969/j.issn.1671-7171.2024.08.013 【Objective】To investigate the effects of ezetimibe on cardiac function and the phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase 3β(PI3K/AKT/GSK3β) pathway after acute myocardial infarction in hyperlipidemic rats. 【Methods】Fifty successfully modeled hyperlipidemic rats were randomly divided into a high-fat sham surgery group (n=16), a high-fat AMI group (n=17), and an ezetimibe group (n=17). Eight rats were randomly selected and fed with regular feed (normal control group). The high-fat AMI group and ezetimibe group rats underwent coronary artery ligation surgery to establish AMI models (the high-fat sham surgery group only had suture without ligation). 48 hours after surgery, there were 10, 9, and 9 surviving rats in the high-fat sham surgery group, high-fat AMI group, and ezetimibe group, respectively. We compared the levels of left ventricular end systolic volume (LVESV), left ventricular end diastolic diameter (LVEDV), and left ventricular ejection fraction (LVEF) in each group of rats after gastric lavage, observed the pathological changes in rat myocardial tissue, compared the apoptosis index (AI) of myocardial cells in each group, and compared the changes in PI3K, p-PI3K, AKT, p-AKT, GSK3β, and p-GSK3β protein levels in myocardial tissue. 【Results】Compared with the normal control group and high-fat sham surgery group, the levels of LVEDV and LVESV increased (P<0.05) and LVEF decreased in the high-fat AMI group and ezetimibe group rats(P<0.05); The LVEDV and LVESV levels in the ezetimibe group were lower than those in the high-fat AMI group (P<0.05), and the LVEF level was higher than that in the high-fat AMI group (P<0.05). Compared with the high-fat AMI group rats, the pathological changes in the myocardial tissue of the ezetimibe group rats were improved. Compared with the normal control group and the high-fat sham surgery group, the AI levels of myocardial cells in the high-fat AMI group and the ezetimibe group were increased (P<0.05); The AI level of myocardial cells in the ezetimibe group was lower than that in the high-fat AMI group (P<0.05). Compared with the normal control group and high-fat sham surgery group, the levels of p-PI3K/PI3K, p-AKT/AKT, and p-GSK3β/GSK3β in the myocardial tissue of rats in the high-fat AMI group and ezetimibe group were all reduced (P<0.05); The levels of p-PI3K/PI3K, p-AKT/AKT, and p-GSK3β/GSK3β in the myocardial tissue of rats in the ezetimibe group were higher than those in the high-fat AMI group (P<0.05). 【Conclusion】Ezetimibe may inhibit myocardial cell apoptosis by promoting the activation of the PI3K/AKT/GSK3β pathway, and exert a protective effect on cardiac function in hyperlipidemic rats after AMI. 2024 Vol. 41 (8): 1164-1167 [Abstract] ( 31 ) HTML (1 KB)  PDF (1704 KB)  ( 31 ) 1168 Efficacy and Safety of Different Surgical Approaches in Infantile Cataract Surgery GE Jilin, ZHANG Yongkang, LI Bo DOI: 10.3969/j.issn.1671-7171.2024.08.014 【Objective】 To observe the efficacy and safety of different surgical approaches in infantile cataract surgery. 【Methods】 A total of 86 cases (137 eyes) of pediatric cataract patients treated in our hospital from July 2015 to September 2019 were included in the study. The patients were divided into an anterior approach group (47 cases) and a posterior approach group (39 cases) according to the surgical approaches. The children were followed up for 3 years after discharge. The axial length and corneal curvature of the two groups were measured and compared preoperatively, 6 months postoperatively, 1 year postoperatively, and 3 years postoperatively. The best corrected visual acuity of one eye and both eyes at the last follow-up visit, as well as the incidence of complications, were also compared between the two groups. 【Results】There were no significant differences in the axial length and corneal curvature between the two groups preoperatively, 6 months postoperatively, 1 year postoperatively, and 3 years postoperatively (P>0.05). The axial lengths at 6 months postoperatively, 1 year postoperatively, and 3 years postoperatively were significantly longer than those preoperatively, and the corneal curvatures were significantly smaller than those preoperatively in both groups (P<0.05). There were no significant differences in the best corrected visual acuity of one eye and both eyes at the last follow-up visit between the two groups (P>0.05). There were no significant differences in the incidences of iris adhesions, intraocular lens displacement, and secondary cataracts between the two groups (P>0.05). The anterior approach group had significantly lower incidences of strabismus and nystagmus than the posterior approach group (P<0.05). 【Conclusion】 Both posterior and anterior approaches in infantile cataract surgery can effectively treat cataracts. The anterior approach can reduce postoperative complications and has better clinical application value. 2024 Vol. 41 (8): 1168-1170 [Abstract] ( 28 ) HTML (1 KB)  PDF (1219 KB)  ( 30 ) 1171 Effect of Dexmedetomidine Combined with Spinal-Epidural Anesthesia on Analgesia, Postoperative Sleep and Incidence of Depression in Parturients with Cesarean Section HUANG Wei, WANG Tingting DOI: 10.3969/j.issn.1671-7171.2024.08.015 【Objective】This study aims to explore the analgesic effects of Dexmedetomidine (Dex) combined with Spinal-Epidural Anesthesia (CSEA) on analgesia, postoperative sleep quality and risk of depression during cesarean delivery. 【Methods】Seventy parturients undergoing cesarean section were randomly divided into the observation group and the control group, with 35 subjects in each group. The control group received CSEA, and the observation group received Dex in addition to CSEA. The sedation score (Ramsay), visual analog scale (VAS) for pain, preoperative and postoperative sleep quality, depression scores, hemodynamics, adverse reactions, and neonatal Apgar scores were compared between the groups. 【Results】Post-anesthesia Ramsay scores in both groups were higher immediately after anesthesia; And the 24-hour postoperative VAS scores were higher than those at 1-hour post-surgery (P<0.05). The observation group showed higher post-anesthesia Ramsay scores and lower 24-hour postoperative VAS scores compared to the control group (P<0.05). Postoperative Athens Insomnia Scale (AIS) scores in both groups were higher than those preoperative scores, and postoperative Self-Rating Depression Scale (SDS) scores were lower than those preoperative scores in both groups (P<0.05), with the observation group showing lower postoperative AIS and SDS scores than the control group (P<0.05). The observation group's neonatal respiratory, heart rate, and skin color scores were significantly higher than those in the control group (P<0.05), while there were no significant differences in muscle tone and laryngeal reflex scores between the groups (P>0.05). There was no significant difference in postoperative oxygen saturation (SpO2) levels between the groups (P>0.05), however, the heart rate (HR) and mean arterial pressure (MAP) were significantly lower postoperatively than preoperatively (P<0.05), with higher postoperative HR and MAP levels in the observation group (P<0.05). The overall incidence of adverse reactions was significantly lower in the observation group (P<0.05). 【Conclusion】The use of Dex combined with CSEA for cesarean delivery significantly enhances analgesia and sedation with effectively reducing pain, improving sleep quality, and alleviating depressive symptoms, It is worthy of clinical application. 2024 Vol. 41 (8): 1171-1174 [Abstract] ( 31 ) HTML (1 KB)  PDF (1183 KB)  ( 20 ) 1175 The Value of Combined Detection of Serum SAA, IL-12, and IL-6 in Assessing the Severity of Hand, Foot, and Mouth Disease in Children SHI Huan, LI Shu, ZHENG Zhenxing, et al DOI: 10.3969/j.issn.1671-7171.2024.08.016 【Objective】 To explore the value of combined detection of serum amyloid A (SAA), interleukin-12 (IL-12), and interleukin-6 (IL-6) levels in assessing the severity of hand, foot, and mouth disease (HFMD) in children.【Methods】 A total of 100 HFMD children were selected as the observation group, and 100 healthy children undergoing physical examination in the same period served as the control group. The children in the observation group were divided into mild (n=46), severe (n=34), and critical (n=20) groups based on the severity of their conditions. Serum levels of SAA, IL-12, and IL-6 in children with HFMD and healthy children were compared. The diagnostic value of these serum levels for HFMD was analyzed using the receiver operating characteristic (ROC) curves. The data of children with different severity levels were compared, and the correlation between serum levels of SAA, IL-12, and IL-6 and disease severity was analyzed.【Results】 The levels of serum SAA, IL-12, and IL-6 in the observation group were significantly higher than those in the control group (P<0.05). ROC analysis showed that the areas under the curve (AUC) for serum SAA, IL-12, and IL-6 levels were 0.873, 0.843, and 0.840, respectively, with sensitivities of 0.870, 0.820, and 0.830, respectively (all P<0.05). The levels of serum SAA, IL-12, and IL-6 in the critical group were significantly higher than those in the mild and severe groups, and their levels in the severe group were significantly higher than those in the mild group (P<0.05). Correlation analysis showed that the levels of serum SAA, IL-12, and IL-6 were positively correlated with the severity of the disease (all P<0.05).【Conclusion】 The levels of serum SAA, IL-12, and IL-6 can predict the severity of HFMD in children. The higher these levels detected, the more severe condition for the child. 2024 Vol. 41 (8): 1175-1177 [Abstract] ( 32 ) HTML (1 KB)  PDF (1273 KB)  ( 18 ) 1178 The Value of Serum TIMP-1, YKL-40, CRP, and ANCA in the Diagnosis and Prognostic Assessment of Bronchitis in School-aged Children WANG Yu, HE Rong DOI: 10.3969/j.issn.1671-7171.2024.08.017 【Objective】 This study investigated the significance of serum tissue inhibitor of metalloproteinases-1 (TIMP-1), chitinase-3-like protein 1 (YKL-40), C-reactive protein (CRP), and anti-neutrophil cytoplasmic antibodies (ANCA) in the diagnosis and prognostic evaluation of bronchitis in school-aged children. 【Methods】 One hundred children with bronchitis were selected as the observation group, and one hundred healthy school-aged children undergoing physical examination were selected as the control group. After 1-2 weeks of standard treatment, the observation group was divided into a good prognosis group and a poor prognosis group based on treatment outcomes. Levels of TIMP-1, YKL-40, CRP, and ANCA were compared between the observation and the control groups. The diagnostic value of these biomarkers for school-aged bronchitis was analyzed using receiver operating characteristic (ROC) curves. Additionally, levels of these biomarkers before and after treatment, as well as between the good and the poor prognosis groups, were compared, and correlations with prognosis were analyzed. 【Results】 Serum levels of TIMP-1, YKL-40, CRP, and ANCA were significantly higher in the observation group compared to the control group (P<0.05). ROC analysis confirmed that TIMP-1≥228.510 pg/mL, YKL-40≥26.755 ng/L, CRP≥12.130 mg/L, and ANCA≥167.850 AU/mL could be used to diagnose bronchitis in school-aged children, with area under the curve values of 0.895, 0.892, 0.874, and 0.866 respectively (all P<0.05). After treatment, levels of TIMP-1, YKL-40, CRP, and ANCA in the observation group significantly decreased (P<0.05). The good prognosis group had lower levels of these markers compared to the poor prognosis group (P<0.05), and there was a positive correlation between these biomarkers and prognosis in children with bronchitis. 【Conclusion】 Serum levels of TIMP-1, YKL-40, CRP, and ANCA are elevated in children with bronchitis compared to healthy children; The levels of TIMP-1, YKL-40, CRP, and ANCA in bronchitis children decrease after treatment; And they are correlated positively with the prognosis. Clinically, levels of serum TIMP-1, YKL-40, CRP, and ANCA can assist in the diagnosis of bronchitis in school-aged children and in the assessment of prognosis. 2024 Vol. 41 (8): 1178-1181 [Abstract] ( 26 ) HTML (1 KB)  PDF (1249 KB)  ( 17 ) 1182 Clinical Efficacy of Bifidobacterium Quadripartitum Active Tablets Combined with Antibiotics in Severe Pneumonia Children and their Impact on Gut Microbiota and Inflammatory Cytokine Levels CHEN Yajun, XIE Junqi, YUN Liangliang DOI: 10.3969/j.issn.1671-7171.2024.08.018 【Objective】To investigate the clinical efficacy of Bifidobacterium quadruple active tablets combined with antibiotics in severe pneumonia (SP) children on gut microbiota,pulmonary ultrasound score(LUS) and inflammatory cytokine levels. 【Methods】A total of 102 children with SP admitted to our hospital from January 2021 to August 2023 were selected and randomly divided into the control group (conventional symptomatic treatment and antibiotic treatment) and the observation group (combined with Bifidobacterium quadruple viable tablets on the basis of the control group) using a random number table method, with 51 cases in each group. Two groups were compared in terms of clinical efficacy, pre-and post-treatment lung function indicators [forced expiratory volume in one second (FEV1), vital capacity (VC), LUS], gut microbiota [Escherichia coli, Bifidobacterium, Enterococcus, Lactobacillus], inflammatory factors [interleukin (IL-10), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), tumor necrosis factor alpha (TNF-α)] levels. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, FEV1, and VC in both groups were higher than before treatment, LUS was lower than before treatment, the difference was statistical significance in two groups(P<0.05); The levels of Bifidobacterium and Lactobacillus in both groups were higher than before treatment, while the levels of Enterococcus and Escherichia coli were lower than before treatment. The difference between the observation group and the control group was statistically significant (P<0.05); The levels of IL-10 in both groups were higher than before treatment, while the levels of CRP, sICAM-1, and TNF-α were lower than before treatment. The difference between the observation group and the control group was statistically significant (P<0.05). 【Conclusion】The combination of Bifidobacterium quadruple active tablets and antibiotics has good clinical efficacy in treating SP children, inhibiting inflammatory reactions, and improving lung function in children. 2024 Vol. 41 (8): 1182-1184 [Abstract] ( 32 ) HTML (1 KB)  PDF (1223 KB)  ( 34 ) 1185 Clinical Efficacy of Carboprost Tromethamine Combined with Oxytocin in the Treatment of Postpartum Hemorrhage in high-risk Pregnant Women Undergoing Vaginal Delivery NIU Huihui, HAN Lipin DOI: 10.3969/j.issn.1671-7171.2024.08.019 【Objective】To investigate the clinical efficacy of combining carboprost tromethamine with oxytocin in the treatment of postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery. 【Methods】A retrospective analysis was conducted on the clinical data of 82 high-risk pregnant women with postpartum hemorrhage who underwent vaginal delivery in our hospital from February 2019 to February 2023. They were divided into the control group (treated with oxytocin) and the observation group (treated with carboprost tromethamine combined with oxytocin) according to different treatment methods, with 41 cases in each group. Two groups were compared in terms of general information, clinical efficacy, incidence of postpartum adverse reactions, bleeding volume at 1, 3, and 9 hours postpartum, as well as peak systolic velocity (PSV) and pulsatility index (PI) of uterine arteries before treatment, 15 minutes after treatment, and 1 hour after treatment.【Results】The total effective rate of the observation group was higher than that of the control group (P<0.05). The amount of bleeding in the observation group at 3 and 9 hours postpartum was lower than that in the control group at 3 and 9 hours postpartum (P<0.05). Compared with before treatment, both groups showed a decrease in PSV and PI at 15 minutes and 1 hour after treatment (P<0.05); The PSV of the observation group was higher than that of the control group at 15 minutes and 1 hour after treatment, and the PI was lower than that of the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The use of oxytocin combined with carboprost tromethamine in the treatment of postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery is effective, can improve maternal hemodynamic indicators, and has high safety. It is worthy of clinical promotion and application. 2024 Vol. 41 (8): 1185-1187 [Abstract] ( 46 ) HTML (1 KB)  PDF (1163 KB)  ( 17 ) 1188 Analysis of HBV, HCV, HIV and TP Infection among Blood Donors in Central Blood Bank of Hanzhong City YAN Yi, LIU Yongjuan, NIE Pufang, et al DOI: 10.3969/j.issn.1671-7171.2024.08.020 【Objective】To investigate the infection of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and Treponema pallidum (TP) among blood donors in Hanzhong city central blood bank. 【Methods】A total of 1120 blood donors from February 2019 to October 2022 in Hanzhong City were selected and tested for HBV, HCV, HIV and TP infection. The results and demographic characteristics of HBV, HCV, HIV and TP were analyzed. 【Results】Among the HBV, HCV, HIV and TP test results of Hanzhong Central Blood Station, HBsAg positive accounted for the highest proportion 16.07%(180/1120), followed by TP 10.71%(120/1120). The HCV positivity rate was 3.57%(40/1120), and no HIV infection was detected.The proportion of HBV, HCV and TP infections in males was higher than that in females (P<0.05). There were statistically significant differences in HBV, HCV and TP infections among different genders and different education levels (P<0.05), and the proportions of HBV, HCV and TP infections with bachelor's degree or above were lower than those without bachelor's degree (P<0.05). There were statistically significant differences in the proportions of HBV, HCV and TP infections in different blood types and different ages (P<0.05). Among which, blood type O accounted for the highest proportion of HBV and HCV infection, AB blood type accounted for the highest proportion of TP infection, 30~<40 years old people had the highest proportion of HBV and TP infection, and 50~<60 people had the highest proportion of HCV infection.【Conclusion】The risk of HBV, HCV, and TP infection among blood donors at the Hanzhong Central Blood Station is higher, which predominated by HBsAg-positive. Males and those with undergraduate degree or below have a higher proportion of HBV, HCV, HIV, and TP infection. Targeted comprehensive prevention and treatment measures need to be taken. 2024 Vol. 41 (8): 1188-1190 [Abstract] ( 33 ) HTML (1 KB)  PDF (1224 KB)  ( 24 ) 1191 Clinical Efficacy of Bevacizumab Combined with Paclitaxel and Cisplatin Based Synchronous Radiochemotherapy in the Treatment of Cervical Cancer YANG Xinhua, SONG Qing, SI Zhigang, et al DOI: 10.3969/j.issn.1671-7171.2024.08.021 【Objective】To investigate the efficacy of bevacizumab combined with paclitaxel+cisplatin (TP) based synchronous radiochemotherapy in the treatment of cervical cancer. 【Methods】Ninety cervical cancer patients admitted to our hospital from December 2021 to January 2023 were selected and randomly divided into the observation group and the control group using a random number table method, with 45 patients in each group. The control group was treated with TP synchronous radiotherapy and chemotherapy, while the observation group was treated with bevacizumab on the basis of the control group. One treatment cycle was 21 days, and both groups were treated for three cycles. Two groups were compared in terms of clinical efficacy, serological indicators, immune function indicators, quality of life scores, and incidence of adverse reactions. 【Results】The clinical remission rate of the observation group (55.56%) was higher than that of the control group (33.33%) (P<0.05). After treatment, the levels of serum carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCC), and transforming growth factor beta 1 (TGF-β1) decreased in both groups (P<0.05), and the above indicators in the observation group were lower than those in the control group (P<0.05). After treatment, the observation group had higher levels of CD3+ and CD4+ than the control group (P<0.05), and lower levels of CD8+ than the control group (P<0.05). After treatment, the FACT-G scores of both groups of cancer treatment function evaluation scales increased (P<0.05), and the FACT-G score of the observation group was higher than that of the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The combination of bevacizumab and TP based synchronous chemoradiotherapy is effective in treating cervical cancer patients, improving their immune function and quality of life, reducing tumor markers and TGF-β1 expression levels, and has good safety. It is worthy of clinical application. 2024 Vol. 41 (8): 1191-1194 [Abstract] ( 42 ) HTML (1 KB)  PDF (1187 KB)  ( 57 ) 1195 Efficacy of Shuxuetong Injection Combined with Alteplase Thrombolysis in Treating Patients with Acute Cerebral Infarction and its Effects on IL-6, TNF-α, and MMP-9 Levels XU Yafei, YANG Qiang DOI: 10.3969/j.issn.1671-7171.2024.08.022 【Objective】 This study aims to explore the efficacy of Shuxuetong injection combined with alteplase thrombolysis in treating patients with acute cerebral infarction and its effects on interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinase-9 (MMP-9) levels. 【Methods】 One hundred patients with acute cerebral infarction were randomly divided into two groups, with fifty patients in each. The control group received alteplase thrombolysis alone, while the observation group received alteplase thrombolysis treatment combined with Shuxuetong injection. The efficacy, neurological function, daily living ability, hemorheological parameters before and after treatment, changes in IL-6, TNF-α, MMP-9, and C-reactive protein (CRP) levels, and the incidence of adverse reactions in both groups were compared. 【Results】 The total effective rate in the observation group was 92.00%(46/50), which was higher than 82.00%(41/50) in the control group (P<0.05). After treatment the hemorheological parameters in both groups were lower than those before treatment; And those parameters in the observation group were lower than those in the control group (P<0.05). Levels of IL-6, TNF-α, MMP-9, and CRP decreased after treatment in both groups, with even lower levels in the observation group compared to the control group (P<0.05). The National Institute of Health Stroke Scale (NIHSS) scores decreased, and Barthel Index scores increased post-treatment, with better scores in the observation group (P<0.05). No adverse reactions such as drug allergies, purpura, or bleeding occurred during the treatment in both groups. 【Conclusion】 Shuxuetong injection combined with thrombolytic therapy can effectively improve hemorheology, inhibit inflammation, and enhance vascular endothelial function in patients with acute cerebral infarction. Its efficacy is confirmed, and it is worth promoting in clinical applications. 2024 Vol. 41 (8): 1195-1197 [Abstract] ( 36 ) HTML (1 KB)  PDF (1223 KB)  ( 23 ) 1198 The Evaluation Value of Pulmonary Ultrasound Examination on the Severity and Prognosis of Pulmonary Infection Patients LI Jingjing, ZHANG Xiaoguang DOI: 10.3969/j.issn.1671-7171.2024.08.023 【Objective】To explore the evaluation value of pulmonary ultrasound examination on the severity and prognosis of pulmonary infection patients.【Method】A total of 100 patients with pulmonary infections admitted to Mengzhou Fuxing Hospital and the Second Affiliated Hospital of Zhengzhou University in Henan Province from January 2020 to December 2022 were selected as the infection group. In addition, 100 volunteers who did not have pulmonary infections during physical examinations were selected as the control group. Both groups underwent pulmonary ultrasound examination, and the pulmonary ultrasound characteristics and pulmonary ultrasound scores (LUS) of the two groups were compared. Simple linear correlation was used to analyze the correlation between LUS and the acute physiological function and chronic health scoring system (APACHE Ⅱ) score, clinical pulmonary infection score (CPIS), peripheral blood white blood cell (WBC) count, serum prealbumin (SPA), and soluble myeloid trigger receptor-1 (STREM-1) in patients with pulmonary infection. The predictive value of LUS for the prognosis of patients with pulmonary infection was analyzed.【Result】The detection rate of B-line sign, lung consolidation sign, lung sliding sign weakened or disappeared, and air bronchial inflation sign in the infected group was higher than that in the control group, and the difference was statistically significant (P<0.05); The WBC count, serum STREM-1 level, and LUS in the infected group were significantly higher than those in the control group (P<0.05), while the serum SPA level was significantly lower than that in the control group (P<0.05). There was a significant positive correlation between WBC count, serum STREM-1 level, APACHE Ⅱ score, CPIS, and LUS in the infected group(P<0.05) ; The serum SPA level in the infected group was significantly negatively correlated with LUS (P<0.05). After treatment, 17 out of 100 patients died and 83 improved and were discharged. The analysis of Receiver Operating Characteristic (ROC) curves showed that LUS had a sensitivity of 71.04%, specificity of 87.34%, and an area under the ROC curve of 0.884 for predicting mortality in patients with pulmonary infections.【Conclusion】LUS is significantly correlated with the levels of inflammatory factors and the severity of pulmonary infection in patients, and can be used to predict patient prognosis. 2024 Vol. 41 (8): 1198-1201 [Abstract] ( 36 ) HTML (1 KB)  PDF (1204 KB)  ( 11 ) 1202 The Diagnostic Value of Bedside Cardiopulmonary Ultrasound to Identifying Acute Dyspnea Due to Pulmonary Edema or Pneumonia LIU Xuelin, GAO Jiayu, ZHANG Jianlei, et al DOI: 10.3969/j.issn.1671-7171.2024.08.024 【Objective】To evaluate the value of bedside cardiopulmonary ultrasound in differential diagnosis of acute dyspnea caused by pulmonary edema or pneumonia. 【Methods】A total of 152 patients with acute dyspnea treated in our hospital from June 2021 to June 2023 were selected, and chest CT was used as the diagnostic gold standard. Among them, 68 patients had acute dyspnea due to pulmonary edema and 84 patients had acute dyspnea due to pneumonia. Routine examination and bedside cardiopulmonary ultrasound were performed for all patients. The detection results of routine examination and bedside cardiopulmonary ultrasound for acute dyspnea caused by pulmonary edema or pneumonia were collected. Kappa test was used to analyze the consistency of routine examination, bedside cardiopulmonary ultrasound and chest CT diagnosis, and the differential diagnosis value of routine examination and bedside cardiopulmonary ultrasound for acute dyspnea caused by pulmonary edema or pneumonia was compared. 【Results】There was no significant difference in the cost of between routine examination and bedside cardiopulmonary ultrasound (P>0.05), and the time of bedside cardiopulmonary ultrasound was significantly shorter than that of routine examination (P<0.05). The total coincidence rate of bedside cardiopulmonary ultrasound in diagnosing acute dyspnea caused by pulmonary edema or pneumonia was 84.21%, which was higher than that of routine examination (75.00%) (χ2=3.971, P=0.046). Furthermore, Kappa consistency test showed that Kappa=0.625 and 0.731. The AUC for differential diagnosis of acute dyspnea caused by pulmonary edema or pneumonia with routine examination and bedside cardiopulmonary ultrasound was 0.709 and 0.805, respectively. The AUC for differential diagnosis of acute dyspnea caused by pulmonary edema or pneumonia in combination of both routine examination and bedside cardiopulmonary ultrasound was 0.923. 【Conclusion】Bedside cardiopulmonary ultrasound has a certain diagnostic value in the differential diagnosis of acute dyspnea caused by pulmonary edema or pneumonia, among which routine examination combined with bedside cardiopulmonary ultrasound has a higher value in the differential diagnosis of acute dyspnea caused by pulmonary edema or pneumonia. 2024 Vol. 41 (8): 1202-1204 [Abstract] ( 37 ) HTML (1 KB)  PDF (1247 KB)  ( 22 ) 1205 Observation of the Effects of Wrist-Ankle Acupuncture Combined with Ropivacaine and Sufentanil for Labor Analgesia XING Fangfang, GUANG Jianzhong, QI Cuimin DOI: 10.3969/j.issn.1671-7171.2024.08.025 【Objective】 To explore the effects of wrist-ankle acupuncture combined with ropivacaine and sufentanil for labor analgesia.【Methods】 Ninety-four parturients undergoing vaginal delivery were randomly divided into two groups. The control group received analgesia with ropivacaine and sufentanil, while the observation group received additional wrist-ankle acupuncture. The analgesic effects, stress indicators, and other related conditions were compared between the two groups.【Results】 At 1 hour, 3 hours after intervention, and 1 hour postpartum, the Visual Analog Scale (VAS) scores of both groups gradually decreased compared to before intervention, with statistically significant differences at different time points (P<0.05). The observation group had lower VAS scores than the control group (P<0.05). Postpartum, the serum levels of substance P (SP), cortisol (Cor), and neuropeptide Y (NPY) in both groups increased compared to before delivery (P<0.05), but were lower in the observation group than in the control group (P<0.05). The first stage of labor and total labor time were shorter in the observation group than in the control group (P<0.05). At 1 hour, 3 hours after intervention, and 1 hour postpartum, the mean arterial pressure (MAP) and heart rate (HR) of both groups decreased compared to before intervention (P<0.05), and were lower in the observation group than in the control group (P<0.05). After the intervention, the Edinburgh Postnatal Depression Scale (EPDS) scores of both groups increased compared to before intervention (P<0.05), but were lower in the observation group than in the control group (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Wrist-ankle acupuncture combined with ropivacaine and sufentanil for labor analgesia can effectively enhance analgesic effects, stabilize hemodynamic levels, shorten the first stage of labor, reduce postpartum depression, and has good safety. 2024 Vol. 41 (8): 1205-1208 [Abstract] ( 35 ) HTML (1 KB)  PDF (1191 KB)  ( 39 ) 1209 Clinical Efficacy of Thalidomide Combined with Prednisone in the Treatment of Ulcerative Colitis and its Impact on Intestinal Barrier Function and Inflammatory Indicators in Patients JIANG Ruihong, GUO Nannan, WANG Haili, et al DOI: 10.3969/j.issn.1671-7171.2024.08.026 【Objective】To investigate the clinical efficacy of thalidomide combined with prednisone in the treatment of ulcerative colitis (UC) and its effects on intestinal barrier function and inflammatory indicators in patients.【Methods】A retrospective analysis was conducted on the clinical data of 92 UC patients admitted to our hospital l from April 2021 to March 2023. According to the treatment plan, they were divided into the control group (treated with prednisone in addition to conventional treatment) and the observation group (treated with thalidomide in addition to the control group), with 46 patients in each group. After 8 weeks of treatment, the efficacy, disease-related scores (Mayo endoscopic score, UC endoscopic severity index (UCEIS) score), intestinal barrier function related indicators [diamine oxidase (DAO), blood lactate (LAC), bacterial lipopolysaccharide (LPS), D-lactate (D-LA)], inflammation related indicators [Toll like receptor 4 (TLR-4), nuclear factor kappa B (NF-κB), soluble late glycation end product receptor (sRAGE)], and adverse reactions were compared between the two groups.【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the Mayo score and UCEIS score of both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05); The levels of serum DAO, LAC, LPS, and D-LA in both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05); The levels of NF-κB, TLR-4, and sRAGE in both groups were lower than before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the total effective rate of adverse reactions between the two groups (P>0.05).【Conclusion】The combination of thalidomide and prednisone has a good therapeutic effect on UC, which can reduce intestinal mucosal inflammation, improve intestinal barrier function, and is relatively safe. 2024 Vol. 41 (8): 1209-1211 [Abstract] ( 35 ) HTML (1 KB)  PDF (1228 KB)  ( 26 ) 1212 The Value of Platelet Aggregation Rate and Blood Viscosity in Predicting Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction after PCI Surgery WANG Hongzhi DOI: 10.3969/j.issn.1671-7171.2024.08.027 【Objective】 To explore the value of platelet aggregation rate and blood viscosity in predicting major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 【Methods】Ninety eight patients with acute myocardial infarction (AMI) who underwent PCI treatment in our hospital from March 2020 to February 2022 were selected. They were divided into an occurrence group (n=16) and a non occurrence group (n=82) based on the occurrence of MACE within 30 days after surgery. Comparing the clinical data, platelet aggregation rate, and blood viscosity of two groups of patients, logistic multiple regression analysis was used to identify the influencing factors of MACE occurrence after PCI. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of platelet aggregation rate and blood viscosity on the risk of MACE occurrence in AMI patients after PCI. 【Results】The incidence of MACE in AMI patients after PCI is 16.33%. The left ventricular ejection fraction was lower in the occurrence group than in the non occurrence group, and the left ventricular end systolic volume, left ventricular end diastolic volume, platelet aggregation rate, and blood viscosity were higher in the occurrence group than in the non occurrence group, with statistically significant differences (P<0.05). Logistic multiple regression analysis showed that platelet aggregation rate and blood viscosity were both related factors affecting the occurrence of MACE in AMI patients after interventional surgery (P<0.05). The sensitivity, specificity, and AUC of platelet aggregation rate, blood viscosity, and their combined prediction of MACE after PCI were 68.75%, 75.00%, and 68.75%, 78.05%, 73.17%, and 97.56%, respectively, and 0.721, 0.748, and 0.887, respectively (P<0.05).【Conclusion】The combination of platelet aggregation rate and blood viscosity has a high predictive value for the occurrence of intracavitary MACE after AMI intervention. 2024 Vol. 41 (8): 1212-1215 [Abstract] ( 34 ) HTML (1 KB)  PDF (1214 KB)  ( 20 ) 1216 Clinical Efficacy of Entecavir Combined with Silibinin in the Treatment of Hepatitis B Patients with Non-alcoholic Fatty Liver Disease and its Influence on Liver Function ZHAI Yunfeng, LI Xiurong DOI: 10.3969/j.issn.1671-7171.2024.08.028 【Objectives】To investigate the clinical efficacy of entecavir combined with silibinin in the treatment of patients with viral hepatitis B (CHB) complicated with non-alcoholic fatty liver disease (NAFLD) and its impact on liver function. 【Methods】A total of 104 patients with CHB and NAFLD admitted to our hospital from June 2021 to January 2023 were selected and divided into the control group (treated with entecavir in addition to conventional treatment) and the observation group (treated with silibinin in addition to conventional treatment) according to the treatment method, with 52 patients in each group. Two groups were compared in terms of clinical efficacy, liver function [alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor marker alpha fetoprotein (AFP)], liver fibrosis indicators [laminin (LN), type Ⅲ procollagen (PC-Ⅲ), type Ⅳ collagen (Ⅳ-C), hyaluronic acid (HA)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB)]. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, ALT, AST, and AFP levels in both groups were lower than before treatment, and the observation group was lower than the control group (P<0.05); The serum levels of LN, PC-Ⅲ,Ⅳ-C, and HA in both groups were lower than before treatment, and the observation group was lower than the control group (P<0.05); The serum levels of IL-6, TNF-α, and NF-κB in both groups were lower than before treatment, and the observation group was lower than the control group (P<0.05).【Conclusion】 The combination of entecavir and silibinin in the treatment of CHB patients with NAFLD can improve liver function, reduce inflammatory response, and alleviate the progression of liver fibrosis. 2024 Vol. 41 (8): 1216-1218 [Abstract] ( 42 ) HTML (1 KB)  PDF (1166 KB)  ( 18 ) 1219 Clinical Efficacy of Sacubitril Valsartan Combined with Pitavastatin in the Treatment of Coronary Heart Disease Complicated with Heart Failure FEI Yousheng, GAO Jie, ZHANG Chao, et al DOI: 10.3969/j.issn.1671-7171.2024.08.029 【Objective】To investigate the clinical efficacy of sacubitril valsartan combined with pitavastatin in the treatment of coronary heart disease (CHD) with heart failure (HF).【Methods】A retrospective analysis was conducted on the clinical data of 82 patients with CHD combined with HF admitted to our hospital from February 2020 to February 2022. According to the treatment method, they were divided into the control group (treated with pitavastatin in addition to conventional treatment) and the observation group (treated with sacubitril in addition to the control group), with 41 patients in each group. Two groups were compared in terms of clinical efficacy, cardiac function indicators [left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD)], 6-minute walk test (6MWT) distance, and quality of life [Minnesota Heart Failure Quality of Life Scale (LHFQ score)], and the incidence of adverse reactions during treatment was statistically analyzed. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, LVEF in both groups was higher than before treatment, while LVEDD and LVESD were lower than before treatment. The differences between the observation group and the control group were statistically significant (P<0.05). After treatment, the distance between the two groups of 6MWT distarce was greater than before treatment, and the LHFQ score was lower than before treatment. Moreover, the difference between the observation group and the control group was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The combination of sacubitril valsartan and pitavastatin has a good therapeutic effect on CHD complicated with HF, significantly improving patients' cardiac function, enhancing their quality of life, and has high safety. 2024 Vol. 41 (8): 1219-1221 [Abstract] ( 25 ) HTML (1 KB)  PDF (1185 KB)  ( 23 )

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