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| The Value of Combined Detection of Serum SAA, IL-12, and IL-6 in Assessing the Severity of Hand, Foot, and Mouth Disease in Children |
| SHI Huan, LI Shu, ZHENG Zhenxing, et al |
| Department of Laboratory, Yulin Center for Disease Control and Prevention, Yulin Shaanxi 719000 |
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Abstract 【Objective】 To explore the value of combined detection of serum amyloid A (SAA), interleukin-12 (IL-12), and interleukin-6 (IL-6) levels in assessing the severity of hand, foot, and mouth disease (HFMD) in children.【Methods】 A total of 100 HFMD children were selected as the observation group, and 100 healthy children undergoing physical examination in the same period served as the control group. The children in the observation group were divided into mild (n=46), severe (n=34), and critical (n=20) groups based on the severity of their conditions. Serum levels of SAA, IL-12, and IL-6 in children with HFMD and healthy children were compared. The diagnostic value of these serum levels for HFMD was analyzed using the receiver operating characteristic (ROC) curves. The data of children with different severity levels were compared, and the correlation between serum levels of SAA, IL-12, and IL-6 and disease severity was analyzed.【Results】 The levels of serum SAA, IL-12, and IL-6 in the observation group were significantly higher than those in the control group (P<0.05). ROC analysis showed that the areas under the curve (AUC) for serum SAA, IL-12, and IL-6 levels were 0.873, 0.843, and 0.840, respectively, with sensitivities of 0.870, 0.820, and 0.830, respectively (all P<0.05). The levels of serum SAA, IL-12, and IL-6 in the critical group were significantly higher than those in the mild and severe groups, and their levels in the severe group were significantly higher than those in the mild group (P<0.05). Correlation analysis showed that the levels of serum SAA, IL-12, and IL-6 were positively correlated with the severity of the disease (all P<0.05).【Conclusion】 The levels of serum SAA, IL-12, and IL-6 can predict the severity of HFMD in children. The higher these levels detected, the more severe condition for the child.
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Received: 09 June 2023
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2024, Vol. 41 
