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| Relationship of Serum Levels of CRP, Hcy, and MMP-9 with Concurrent Pneumonia in Elderly Patients with Multiple Cerebral Infarctions |
| ZHAI Junge, ZUO Yanyan, XIN Huiqin |
| Department of Neurology, Yichuan County People's Hospital, Luoyang Henan 471300 |
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Abstract 【Objective】To explore the relationship of serum levels of C-reactive protein (CRP), homocysteine (Hcy), and matrix metalloproteinase-9 (MMP-9) with the occurrence of concurrent pneumonia in elderly patients with multiple cerebral infarctions .【Methods】The clinical data of 80 elderly patients with multiple cerebral infarctions were retrospectively analyzed. The patients were divided into two groups based on whether they had hospital-acquired pneumonia: the concurrent pneumonia group (n=18) and the non-concurrent pneumonia group (n=62). General data and serum levels of CRP, Hcy, and MMP-9 were compared between the two groups. The value of CRP, Hcy, and MMP-9 levels in predicting concurrent pneumonia was analyzed using receiver operating characteristic (ROC) curves. Multivariate Logistic regression analysis was applied to identify risk factors for concurrent pneumonia. 【Results】 The proportion of patients aged ≥70 years and those with a history of pulmonary disease was significantly higher in the concurrent pneumonia group than in the non-concurrent pneumonia group (P<0.05). The levels of CRP, Hcy, and MMP-9 were significantly higher in the concurrent pneumonia group compared to the non-concurrent pneumonia group (P<0.05). ROC and Logistic analysis showed that the area under the curve (AUC) values of CRP, Hcy, and MMP-9 in predicting concurrent pneumonia were 0.834, 0.850, and 0.752, respectively (P<0.05). Age ≥70 years, a history of pulmonary disease, CRP ≥21.725 mg/L, Hcy ≥21.420 μmol/L, and MMP-9 ≥385.255 ng/mL were identified as risk factors for concurrent pneumonia (P<0.05).【Conclusion】 Monitoring serum levels of CRP, Hcy, and MMP-9 has predictive value for concurrent pneumonia in elderly patients with multiple cerebral infarctions.
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Received: 20 October 2023
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2024, Vol. 41 
