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Quick Search     Adv Search 2019 Vol. 36, No. 6 Published: 2019-06-30   1041 Expression and Significance Of CD147 and FOXM1 in Cervical Cancer WU Xiang, WU Fei, YANG Li,et al DOI: 10.3969/j.issn.1671-7171.2019.06.001 【Objective】To investigate the expression and significance of CD147 and FOXM1 in cervical cancer. 【Methods】SP immunohistochemical staining was used to detect the expression of CD147 and FOXM1 in 31 cases of cervical cancer and 35 cases in the control group.【Results】The results showed that the positive rates of CD147 and FOXM1 in the cervical cancer group were significantly higher than those in control group,and the positive expression of CD147 and FOXM1 was closely related to the stage of FIGO 2018 cervical cancer; moreover, in cervical cancer, expression of CD147 was positively related with FOXM1(P＜0.01). 【Conclusions】CD147 and FOXM1 played an important role in invasion and metastasis of cervical cancer. Joint detection of CD147 and FOXM1 was expected to be new index for judging the prognosis of cervical cancer. 2019 Vol. 36 (6): 1041-1043 [Abstract] ( 102 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1044 Therapeutic Effect of Letrozole Combined with HCG on Patients with Polycystic Ovary Syndrome DING Xia, PAN Chang-qing DOI: 10.3969/j.issn.1671-7171.2019.06.002 【Objective】To investigate the clinical efficacy of letrozole combined with HCG in the treatment of patients with polycystic ovary syndrome. 【Methods】A total of 120 PCOS patients admitted to gynecology department of our hospital from January 2015 to August 2018 were selected and divided into observation group and control group according to random number table method, 60 cases in each group. The control group was treated with letrozole, while the observation group was treated with HCG on the basis of the control group. The levels of sex hormones testosterone (T), progesterone (PRGE), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), vascular endothelial growth factor (VEGF), endostatin (ES) and the incidence of clinical efficacy and adverse reactions were compared between the two groups. 【Results】After treatment, the levels of T, FSH, LH, E2, VEGF and ES in the two groups were significantly decreased, but the levels of each index in the observation group were significantly lower than those in the control group (P<0.05); the ovarian volume in the observation group was significantly smaller than that in the control group, while the follicle diameter and the number of follicles in the observation group were significantly larger than those in the control group, the difference was statistically significant (P<0.05), but the endometrial thickness in the two groups was significantly different (P<0.05). There was no significant difference between the two groups (P>0.05). The ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Letrozole combined with HCG in the treatment of PCOS can effectively reduce the levels of sex hormones, vascular endothelial growth factor and ES, improve ovulation and pregnancy rate. It is safe and worthy of clinical application. 2019 Vol. 36 (6): 1044-1046 [Abstract] ( 88 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1047 Effect of Endometrial Scratching on Wnt Signaling Pathway and Its Regulatory Factors in Repeated Inplantation Patients FENG Hui-jing, ZHAO Shao-hua, ZHENG Jiang-li,et al DOI: 10.3969/j.issn.1671-7171.2019.06.003 【Objective】To investigate the effect of endometrial curettage on Wnt signaling pathway and its regulatory factors in recurrent implantation failure (RIF) patients. 【Methods】 The prospective study recruited a total of 87 patients with RIF who underwent in vitro fertilization in our hospital due to fallopian tube factors sterility from December 2015 to January 2018. There were 43 cases in the endometrial scraping group (the patients underwent endometrial scraping within 6 h of menstrual cramps during the first 1 month of the frozen embryo resuscitation), and 44 cases in the control group (no endometrial scraping before the frozen embryo resuscitation). The expression levels of β-catenin, cyclinD1, Pygo2 and DKK1 were detected by western blotting and real-time PCR in the endometrial implantation window 5-7 days after ovulation. The pregnancy-related conditions (implantation rate, clinical prgenancy rate and sustained pregnancy rate) were determined and compared between the two groups. 【Results】Embryo implantation rate, clinical pregnancy rate and sustained pregnancy rate in scraping group were significantly higher than those in control group (P<0.05). There was no significant difference in the levels of β-catenin, cyclin D1, Pygo2 and inhibitory factor DKK1 between the scratching group and the control group before scratching (P>0.05). After scratching the expressions of β-catenin, cyclin D1 and Pygo2 in the scratching group were significantly higher than those in the control group, while the expression of DKK1 was significantly lower than that in the control group (P<0.001). 【Conclusion】After endometrial curettage, the expression of β-catenin, cyclinD1, and Pygo2 in RIF patients is increased, and the expression of inhibitory factor DKK1 is decreased, which can improve the clinical pregnancy rate of patients with RIF by improving endometrial receptivity. 2019 Vol. 36 (6): 1047-1049 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1050 Effect of Rocuronium on the Repair of Cleft Lip and Palate and the Incidence of Residual Muscle Relaxation after Operation in Bilateral Upper Lip Modified Trapezoidal Mucosal Myocutaneous Flaps XIE Qun, HU Qiang, ZHANG Rui-rui,et al DOI: 10.3969/j.issn.1671-7171.2019.06.004 【Objective】To investigate the effect of rocuronium on the repair of cleft lip and palate and the incidence of residual muscle relaxation in bilateral upper lip modified trapezoidal mucosal myocutaneous flaps.【Methods】Eighty children with cleft lip and palate were selected from January 2015 to January 2019. They were randomly divided into observation group and control group with 40 cases in each group. The control group was treated with bilateral upper lip modified trapezoidal mucosal myocutaneous flaps, while the observation group was treated with rocuronium on the basis of the control group. The treatment effect, onset time, convulsion recovery time, recovery index and parents'satisfaction were compared between the two groups.【Results】There was no significant difference in the therapeutic effect between the two groups (P>0.05); the onset time of anesthesia, convulsion recovery time and recovery index in the observation group were significantly lower than those in the control group; the satisfaction degree of parents was significantly higher than that in the control group, and the difference was statistically significant (P < 0.05).【Conclusion】The application of rocuronium bromide in bilateral upper lip modified trapezoidal mucosal myocutaneous flaps is effective in repairing cleft lip and palate in children. The incidence of residual muscle relaxation after operation is low and parents'satisfaction is high. 2019 Vol. 36 (6): 1050-1052 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 21 ) 1053 Efficacy of Target-oriented Fluid and Conventional Fluid Therapy on the Treatment of Meningioma Resection WANG Ping-rong, YUAN Jian-ping, ZUO Guo-hui DOI: 10.3969/j.issn.1671-7171.2019.06.005 【Objective】To analyze the effect of target-oriented fluid and conventional fluid therapy on the efficacy and cognitive function of patients with meningioma resection 【Methods】A total of 60 patients with meningioma resection were selected in our hospital from August 2015 to December 2017.According to the different therapeutic methods, they were divided into the control group and the observation group. Patients in the control group were treated by conventional liquid treatment whilepatients in the observation group were treated by the target-oriented liquid treatment. Analysis of the clinical effect and indexes (SaO2,SjvO2, PaO2,PjvO2, NSE,S100β,SOD and MDA) of the two groups of patients after treatment was conducted. 【Results】The operation related durations (operation time, hospitalization and ICU) of the observation group were shorter than those of the control group (P<0.05). Before treatment, two groups of patients with NSE,,beta protein of SOD, MDA and brain metabolism index level were compared. There were no statistically significant differences between the two groups (P>0.05). After treatment, the SOD level in patients of the observation group was higher than that of the control group, while NSE, S100β protein and MDA levels were lower than those of the control group, and cerebral metabolic index was better than that of control group; the differences were statistically significant (P<0.05). 【Conclusion】 Target-oriented liquid treatment has positive effect on postoperative rehabilitation and brain metabolism in patients with meningioma resection . Thus, it is worthy of clinical promotion. 2019 Vol. 36 (6): 1053-1055 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1056 Effect of Endoscopic Injection of Snake Venom Hemocoagulase on Coagulation Function and Hemorheology in Upper Gastrointestinal Hemorrhage HUANG Lin DOI: 10.3969/j.issn.1671-7171.2019.06.006 【Objective】To investigate the effect of endoscopic injection of snake venom hemocoagulase on coagulation function and hemorheology in patients with upper gastrointestinal hemorrhage.【Methods】One hundred and thirty-six patients with upper gastrointestinal bleeding admitted to our hospital from July 2015 to June 2016 were selected as the study subjects, and randomly divided into observation group and control group with 68 cases in each group. The control group was sprayed and injected with 1:10000 epinephrine under endoscope. The observation group was injected with snake venom hemocoagulase on the basis of the control group. The hemostatic effect, coagulation function, Hemorheology and adverse reactions were compared between the two groups.【Result】The effective rate of the observation group was 95.59% higher than 85.29% of the control group, and the operative rate was 1.47% lower than 10.29% of the control group (all P<0.05); after 3 days of treatment, the prothrombin time (PT) and partial thromboplastin time (APTT) of the observation group were significantly shorter than those of the control group, and the platelet (PLT) and fibrinogen (FIB) were significantly higher than those of the control group (all P<0.05). High shear viscosity, whole blood low shear viscosity and hematocrit were significantly higher than those of the control group, and ESR was significantly lower than those of the control group (all P<0.05). Complications such as abdominal pain and fever in the two groups had no statistical significance (7.35% vs 4.41%, P<0.05).【Conclusion】Endoscopic injection of snake venom hemagglutinin can improve the hemostatic effect and reduce the operation rate in patients with upper gastrointestinal hemorrhage. The mechanism may be related to the improvement of blood coagulation function and the regulation of hemorheology. 2019 Vol. 36 (6): 1056-1058 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1059 Diagnostic value of Echocardiography in Early Closure and Stenosis of Fetal Ductus Arteriosus in the middle and Late Pregnancy XU Guang-lian DOI: 10.3969/j.issn.1671-7171.2019.06.007 【Objective】To explore the diagnostic value of echocardiography (ECG) in early closure and stenosis of fetal ductus arterio sus in late pregnancy.【Methods】The clinical and ECG data of 22 fetuses with premature closure and stenosis of ductus arteriosus diagnosed postpartum in our hospital from January 2017 to January 2019 were retrospectively analyzed. The prenatal and postpartum ECG imaging features were compared to evaluate the clinical value of ECG in the diagnosis of premature closure and stenosis of ductus arteriosus in fetus.【Results】The diagnostic accuracy of echocardiography for early closure and stenosis of fetal ductus arteriosus was 90.91% (20/22), and 2 cases were missed. Fetal echocardiographic features of premature closure and stenosis of ductus arteriosus during fetal period: right heart enlargement (mean diameter of right atrium 14.3 mm, mean diameter of right ventricle 14.7 mm), tricuspid valve with mild to moderate regurgitation, mean regurgitation velocity (163.75±13.42) cm/s, mean transvalvular pressure difference (61±11) mmHg; pulmonary valve mild to moderate regurgitation, mean regurgitation velocity (243.84 ±19.50) cm/s, the average transvalvular pressure difference was (29±9) mmHg. Pulmonary artery widening was observed in all 20 fetuses. The ratio of pulmonary artery diameter to aortic diameter was greater than 1.2. The mean diameter of the ductus arteriosus was (2.3±0.7) cm. Turbulent flow signals could be seen by ultrasound. The systolic flow velocity in the duct was more than 170.0 cm/s. 24 h postnatal echocardiographic characteristics: without detecting the arterial duct and its blood flow signals, the average diameter of right atrium was (13.7±0.6) cm, and the average diameter of right ventricle was (11.7±0.5) cm; the tricuspid regurgitation velocity was lower than that of fetal period, the average blood flow velocity was (246.37±11.08) cm/s, the pulmonary artery widening was improved, and the average diameter of pulmonary artery was (9.0±0.4) mm. Three months after birth, echocardiographic characteristics: right atrium, right ventricle diameter, pulmonary artery pressure were normal; 16 cases had no tricuspid regurgitation, 6 cases had mild tricuspid regurgitation.【Conclusion】Echocardiography is of high value in prenatal diagnosis of fetal ductus arteriosus early closure and stenosis. It is helpful for clinicians to evaluate the condition and provide basis for clinical delivery time. 2019 Vol. 36 (6): 1059-1062 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 1063 Effect of Network Education Management on Health Behavior and Quality of Life of Patients with Ulcerative Colitis SUN Cui-zhen, ZHANG Shan-shan, SUN Jin-feng,et al DOI: 10.3969/j.issn.1671-7171.2019.06.008 【Objective】To explore the effect of network education management on health behavior and quality of life of patients with ulcerative colitis. 【Methods】 One hundred and eight patients with ulcerative colitis admitted to our hospital from February 2016 to July 2018 were randomly divided into observation group and control group with 54 cases in each group. The control group was given routine nursing management including psychological intervention, health education, dietary guidance, prevention of complications and follow-up. The observation group was combined with network education management on the basis of the control group. One month after discharge, health behavior completion rate, disease activity index and quality of life score were compared between the two groups.【Results】 The completion rate of taking medicine on time, reasonable diet and regular review in the observation group was significantly higher than that in the control group (P<0.05); the disease activity index was significantly lower than that in the control group (P<0.05); the scores of intestinal symptoms, emotional function, systemic symptoms and social function were significantly higher than those in the control group (P<0.05). 【Conclusion】 Network education management is helpful to promote the development of healthy behavior ability of ulcerative colitis patients, control disease activity, and improve the quality of life. 2019 Vol. 36 (6): 1063-1065 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1066 Changes and Significance of Serum Bilirubin and Uric Acid Levels in Patients with Type 2 Diabetic Nephropathy HUANG Gui-rui, SUN Guo-ming DOI: 10.3969/j.issn.1671-7171.2019.06.009 【Objective】To investigate the changes and significance of serum bilirubin (TB) and uric acid (UA) levels in patients with type 2 diabetic nephropathy.【Methods】Among the type 2 diabetic patients diagnosed and treated in our hospital, 30 patients with normal urinary albumin excretion rate (UAER < 30mg/24h) were in the normal group, 30 patients with early type 2 diabetic nephropathy (DN) (30~300 mg/24h) were in the early group, and 30 patients with DN (>300 mg/24h) were in the DN group.The condition of diabetes mellitus, renal function index, serum TB and UA levels and their correlation with renal function index were compared among the three groups.【Results】HbA1c and fasting C-peptide in the DN group were significantly higher than those in the normal group and the early group (P<0.05); HbA1c and fasting C-peptide in the early group were significantly higher than those in the normal group (P<0.05); UAER and serum creatinine (SCr) in the DN group were significantly higher than those in the normal group and the early group (P<0.05); and endogenous creatinine clearance rate (CCr) in the early group was significantly higher than those in the normal group and the early group (P<0.05). UA in the DN group was significantly higher than that in the normal group (P<0.05), TB in the DN group was significantly lower than that in the normal group and the early group (P<0.05), UA in the early group was significantly higher than that in the normal group (P<0.05), TB in serum was negatively correlated with UAER, SCr and CCr (P<0.05), UA level was positively correlated with UAER, SCr and CCr (P<0.05). 【Conclusion】The occurrence and development of type 2 diabetic nephropathy is accompanied by the decrease of serum TB and the increase of UA level, which can be used as a new target for early diagnosis and clinical treatment of DN. 2019 Vol. 36 (6): 1066-1068 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 1069 Effects of Aerobic Exercise Combined with Relaxation Training on Blood Pressure, Emotion and Maternal and Infant Outcomes in Patients with Pregnancy-induced Hypertension WANG Qing-ping DOI: 10.3969/j.issn.1671-7171.2019.06.010 【Objective】To investigate the effect of aerobic exercise in combination with relaxation training on blood pressure, negative emotion and maternal-infant outcome of patients with pregnancy-induced hypertension. 【Methods】 A total of 126 cases of hypertensive disorder of pregnancy were selected from July 2014 to June 2016. They were divided into observation group and control group according to random number table method, 63 cases in each group. The control group was given routine nursing, while the observation group was given aerobic exercise combined with relaxation training on the basis of the control group. The blood pressure control, negative emotions and maternal and infant outcomes were compared between the two groups before delivery.【Results】Two groups of patients actually completed the study in 62 cases. The systolic blood pressure, diastolic blood pressure and pulse pressure difference in the observation group were significantly lower than those in the control group (P<0.05), and the scores of anxiety (SAS) and depression (SDS) were significantly lower than those in the control group (P<0.05). Follow-up to delivery showed that preterm delivery, postpartum hemorrhage and placental abruption were 8.06%, 6.45% and 3.23% in the observation group, which were significantly lower than those in the control group (20.97%, 19.35% and 12.90%); neonatal body mass and gestational weeks of termination of pregnancy were (3770.56±418.67) g and (38.7±0.78) weeks, respectively, which were significantly higher than those in the control group (3420.73 ±349.86) g and (38.41±0.60) weeks, with statistical significance (P<0.05). 【Conclusion】 Aerobic exercise combined with relaxation training can help control the blood pressure level of patients with pregnancy-induced hypertension, alleviate anxiety and depression, and improve maternal and infant outcomes, which is worthy of clinical application. 2019 Vol. 36 (6): 1069-1071 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1072 Effect of Experiential Delivery Combined with Psychological Nursing on Mental Health, Natural Delivery Rate and Health Knowledge of Primipara LIU Jun-fang, LIU Ya-lan, WEN Ju-ying, et al DOI: 10.3969/j.issn.1671-7171.2019.06.011 【Objective】To explore the effects of experiential delivery combined with psychological nursing on mental health, natural delivery rate and health knowledge of primipara. 【Methods】 Two hundred and eighty-eight cases of primipara delivered in our hospital from January 2017 to January 2018 were selected and divided into observation group and control group according to random number table method, 144 cases in each group. The control group was only given psychological nursing, while the observation group was given experiential delivery on the basis of the control group. The duration of labor, mode of delivery, health knowledge, nursing satisfaction and anxiety and depression before and after intervention were compared between the two groups. 【Results】The first, second and total stages of labor in the observation group were significantly shorter than those in the control group (P<0.05). There was no significant difference in cesarean section rate and midwifery rate between the two groups (P>0.05). The natural delivery rate in the observation group was 70.83%, which was significantly higher than 56.25% in the control group (P<0.05). The scores of SAS and SDS were lower than those before intervention, and the scores of observation group were significantly lower than those of control group (P<0.05); the excellent rate of health knowledge mastery and nursing satisfaction of observation group were significantly higher than those of control group (P<0.05).【Conclusion】Experiential delivery combined with psychological nursing can shorten the labor process, improve the natural delivery rate, improve the bad mood of primipara, better grasp health knowledge, and ensure the quality of nursing. It has the value of popularization and application. 2019 Vol. 36 (6): 1072-1074 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1075 Effect of Percutaneous Coronary Intervention on Acute Myocardial Infarction with Type 2 Diabetes Mellitus and Adverse Cardiovascular Events JIANG Wei-li, XU Tie DOI: 10.3969/j.issn.1671-7171.2019.06.012 【Objective】To investigate the efficacy of direct percutaneous coronary intervention (PCI) in the treatment of acute myocardial infarction (AMI) with type 2 diabetes mellitus. 【Methods】 One hundred and forty-two patients with AMI in our hospital were selected, including 41 patients with type 2 diabetes mellitus (observation group) and 101 patients without type 2 diabetes mellitus (control group), the near and long term major adverse cardiovascular events (MACE) were compared between the two groups. 【Results】There was no significant difference between the two groups in infarct location, culprit vessel, operation time and TIMI blood flow grade 2-3 (P>0.05). The proportion of multiple vessel lesions and the number of stents implanted in the observation group were significantly higher than those in the control group (P<0.05). The incidence of heart failure in the observation group was significantly higher than that in the control group (P<0.05) in one month after treatment (P<0.05). The incidence of failure and stent restenosis was significantly higher than that of control group (P<0.05). 【Conclusion】The pathological changes of AMI patients with type 2 diabetes mellitus are more serious than those without diabetes mellitus, and the incidence of MACE in the near and long term is higher. 2019 Vol. 36 (6): 1075-1077 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1078 Effect of WeChat Platform Interaction on Self-Management Ability and Anxiety and Depression of Peritoneal Dialysis Patients in Suburban Hospitals NI Wei-wei, YU Mei, CHEN Ya-wen,et al DOI: 10.3969/j.issn.1671-7171.2019.06.013 【Objective】To explore the effect of WeChat platform interaction on self-management ability, anxiety and depression of peritoneal dialysis patients in suburban hospitals. 【Methods】A total of 82 cases of peritoneal dialysis patients treated in suburban hospitals from January 2016 to September 2018 were selected and randomly divided into the research group and the control group. Patients in control group were given conventional nursing of peritoneal dialysis, while patients in research group were given standardized instruction on peritoneal dialysis by WeChat platform based on routing nursing. After 6 months' intervention, the self-management ability, anxiety, depression and life quality of peritoneal dialysis patients were compared.【Results】 The self-management ability, quality of life and nursing satisfaction of the research group were significantly higher than those in the control group (P<0.05). The anxiety and depression in the research group were significantly lower than those in the control group (P<0.05). 【Conclusion】The standardized guidance of WeChat platform can effectively improve the self-management ability, quality of life and nursing satisfaction of patients with peritoneal dialysis and alleviate the negative psychological emotion of patients. It is worthy of widespread promotion in the clinic. 2019 Vol. 36 (6): 1078-1080 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1081 Comparative Study of Tympanic Membrane Occlusion and Combined Gland Resection in Children with Secretory Otitis Media YIN Xian-hui, ZOU Jian DOI: 10.3969/j.issn.1671-7171.2019.06.014 【Objective】To investigate the effect of tympanic membrane occlusion and combined gland resection on the clinical efficacy of children with secretory otitis media. 【Methods】A retrospective analysis of 87 children (127 ears) of children with secretory otitis media admitted to our hospital from January 2014 to February 2017 was performed. Among them, 45 cases (65 ears) underwent tympanic catheterization as a control group. A total of 42 cases (62 ears) treated with tympanic membrane occlusion and gland resection were observed. Clinical total curative effect, frequency band air conduction, average hearing valve and middle ear effusion time and recurrence rate, and infection rate in the two groups were compared. 【Results】The total clinical efficacy of the observation group was higher than that of the control group (P<0.05). There was no significant difference in the mean frequency of the airway in the two groups (P>0.05). The time of the ear effusion in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in the infection rate and recurrence rate between the two groups (P>0.05). After 1 year of operation, the infection rate and recurrence rate of the observation group were lower than those of the control group (P<0.05). 【Conclusion】The tympanic tympanostomy combined with gland resection for the treatment of children with secretory otitis media is effective, which can improve the average frequency of air conduction in the patient's speech frequency zone, reduce the time of middle ear effusion, and promote the rehabilitation of patients. The recurrence rate and infection rate are relatively low, and the long-term efficacy is significant. So, it is worth promoting. 2019 Vol. 36 (6): 1081-1083 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1084 Changes and Significance of Serum LTB4, IL-17 Levels and Pulmonary Function in Children with Acute Bronchial Asthma SONG Xiao-fang, JIA Ling, LAN Fu-rong DOI: 10.3969/j.issn.1671-7171.2019.06.015 【Objective】To investigate the functional changes and clinical significance of serum leukotriene B4 (LTB4), interleukin 17 (IL-17) and pulmonary function in children with acute bronchial asthma. 【Methods】 Ninety children with acute asthma were divided into mild group, moderate group and severe group according to the severity of the disease. Thirty healthy children were selected as control group. The levels of serum LTB4, IL-17, IgE and pulmonary function were compared among the four groups. 【Results】 The serum levels of IL-17, LTB4 and IgE in the mild, moderate and severe asthma groups increased gradually with the deepening of asthma, especially in the severe asthma group. There were significant differences among the groups (P<0.05). There was no significant difference in the levels of LTB4 between the mild group and the control group (P>0.05). The levels of each index in three groups of children with different degrees of asthma were significantly higher than those in the control group (P<0.05). The ratio of forced expiratory volume (FEV1)/forced vital capacity (FVC) in the first second (FEV1%), maximum expiratory flow (PEF), 50% and 25% vital capacity (V50, V25) of children in the mild, moderate and severe groups gradually decreased with the deepening of asthma, and the correlation value of lung function in the severe group decreased most significantly, with significant differences among the groups (P<0.05). 【Conclusion】 The serum levels of LTB4 and IL-17 in children with acute bronchial asthma are significantly increased, and the pulmonary function indexes such as PEF, FEV1%, V50% and V25% were significantly decreased, which is related to the severity of the disease. 2019 Vol. 36 (6): 1084-1086 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 1087 Effect of 72 Cases of Female Vestibular Cyst or Abscess Treated by Simple Latex Ring Modified Stoma WANG Xiao-bin, CHEN Kui-xi DOI: 10.3969/j.issn.1671-7171.2019.06.016 【Objective】To investigate the clinical effect of modified latex ring ostomy in the treatment of female vestibular gland cyst or abscess. 【Methods】A total of 143 patients with vestibular gland cyst or abscess who were treated in our hospital from January 2015 to January 2018 were randomly divided into the traditional group (n=71) and the improved group (n=72). The traditional group underwent traditional vestibular cyst or abscess ostomy, while the improved group underwent simple modified latex ring ostomy. The clinical efficacy, intraoperative condition (operation time, intraoperative bleeding volume and 1% lidocaine dosage), postoperative condition (time of getting out of bed and hospital stay), postoperative pain degree and duration of pain were compared between the two groups. 【Results】The cure rate of the improved group was significantly higher than that of the traditional group (P<0.05). The recurrence rate, post-operative inflammation rate and post-operative pain degree of the improved group were significantly lower than those of the traditional group (P<0.05). The operation time, intraoperative bleeding volume and 1% lidocaine dosage in the modified group were significantly less than those in the traditional group (P<0.05). The time of getting out of bed, hospitalization and pain duration in the improved group were significantly shorter than those in the traditional group (P<0.05). 【Conclusion】Simple modified latex ring ostomy for female patients with vestibular gland cyst or abscess is effective. It can shorten the operation time, reduce intraoperative bleeding and 1% lidocaine usage, shorten the time of exhaustion, ambulation and hospitalization, reduce the degree of pain and shorten the duration of pain. It is worthy of clinical application. 2019 Vol. 36 (6): 1087-1089 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1090 Ultrasound-guided PVB in PCNL Surgery and its Effect on Inflammatory Stress Response PENG Hong, ZHEN Dong, LIU Hong DOI: 10.3969/j.issn.1671-7171.2019.06.017 【Objective】To investigate the effect of ultrasound-guided paravertebral nerve block anesthesia (PVB) in percutaneous nephrolithotomy (PCNL) and its effect on inflammatory stress response. 【Methods】 One hundred and twenty cases of renal calculi undergoing PCNL were randomly divided into PVB group (ultrasound-guided PVB) and general anesthesia group (general anesthesia), 60 cases each. Before anesthesia (T0), 10 minutes after anesthesia (T1), after establishment of lithotripsy channel (T2), during lithotripsy (T3), heart rate (HR) after operation (T4) and mean arterial pressure (MAP) were compared between the two groups. The changes of serum interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α) and cortisol before and 24 hours after operation were compared between the two groups.The dosage of sufentanil 24 hours after operation and the times of pressing by PCIA pump were compared between the two groups.【Results】 There was no significant difference between the two groups at T0 (P>0.05); HR value in PVB group was lower than that in the general anesthesia group at T1 and T2, and MAP value was higher than that in the general anesthesia group (P<0.05); serum IL-6, TNF-αand cortisol in the PVB group were lower than those in the general anesthesia group at 24h after operation, and IL-10 was higher than that in the general anesthesia group (P<0.05); sufentanil dosage and PCIA pump compression times in PVB group were lower than those in general anesthesia group at 24h after operation (P<0.05) 【Conclusion】Ultrasound-guided application of PVB in PCNL is conducive to maintaining hemodynamic stability, alleviating inflammatory stress induced by surgery, reducing sufentanil dosage and PCIA pressing times. 2019 Vol. 36 (6): 1090-1092 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1093 Predictive Value of Ischemic Modified Albumin for Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction During Hospitalization MA Mu-xin, ZHOU Li-jun, ZHAO Ji-yi DOI: 10.3969/j.issn.1671-7171.2019.06.018 【Objective】To evaluate the predictive value of ischemia modified albumin (IMA) for the in-hospital major adverse cardiovascular events (MACE).in patients with acute myocardial infarction (AMI).【Methods】Peripheral circulation IMA levels were measured in 80 patients with AMI at admission. According to the occurrence of MACE during hospitalization, patients were divided into MACE group (n=16) and non-MACE group (n=64). The correlation between troponin I (cTnI) and creatine kinase isoenzyme MB (CK-MB) and IMA was analyzed. The predictive value of IMA for MACE in patients with AMI during hospitalization was evaluated by ROC curve. The relationship between IMA and MACE in patients with AMI during hospitalization was analyzed by logistic regression.【Results】 The levels of IMA, CK-MB and cTnI in MACE group were significantly higher than those in non-MACE group (P<0.05); IMA was positively correlated with cTnI (r=0.573); ROC curve showed that IMA could be used as an indicator of MACE in patients with AMI during hospitalization. The area under curve (AUC) (95% CI) was 0.89 (0.79~0.97), and the optimal diagnostic threshold was 65.33 U/mL. Logistic regression analysis showed that IMA > 65.33 U/mL was an independent risk factor for MACE in patients with AMI during hospitalization.【Conclusions】IMA can be used as a predictor of MACE during AMI hospitalization, and IMA > 65.33 U/mL is an independent risk factor. 2019 Vol. 36 (6): 1093-1095 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1096 Second Generation Sequencing of TSHR, PAX8, TTF1, TTF2 and NKX2.5 Genes in 14 Children with Congenital Hypothyroidism CHEN Xiao-yu, QIN Xiao-song, LIU Jian-hua,et al DOI: 10.3969/j.issn.1671-7171.2019.06.019 【Objective】To investigate the gene mutations of TSHR, PAX8, TTF1, TTF2 and NKX2.5 in children with congenital hypothyroidism (CH), and to analyze the types and characteristics of gene mutations, so as to provide reference for early screening and clinical gene diagnosis of neonates.【Methods】Genomic DNA was extracted from 14 children with CH and all exons of TSHR, PAX8, TTF1, TTF2 and NKX2.5 genes were amplified by PCR. The amplified products were sequenced by second generation sequencing.【Results】The mutation sites were detected in 9 children with CH. Five suspicious pathogenic gene mutations were found in TSHR gene, two suspicious pathogenic gene mutations were found in PAX8 gene, one suspicious pathogenic gene mutation was found in TTF1 gene and TTF2 gene respectively, and no suspicious pathogenic gene mutation was found in NKX2.5 gene.【Conclusions】The known candidate genes TSHR, PAX8, TTF1 and TTF2 in children with CH all have gene mutations and further enlarged the mutation spectrum of TSHR gene. However, the specific relationship between genotype and phenotype is still unclear, and a large number of functional experiments are needed to verify it. 2019 Vol. 36 (6): 1096-1099 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1100 Preventive Value of Early Perinatal Health Care and Nutritional Guidance for Gestational Diabetes Mellitus and Premature Gelivery QIAO Ling DOI: 10.3969/j.issn.1671-7171.2019.06.020 【Objective】To explore the value of early perinatal health care and nutritional guidance in the prevention of gestational diabetes mellitus (GDM) and premature delivery.【Methods】 One hundred and nine pregnant women who underwent maternity examination in our hospital from July 2016 to March 2018 and eventually delivered in our hospital were divided into observation group (51 cases) and control group (58 cases) according to random number table method. Pregnant women in the control group received routine health education and health guidance during pregnancy and childbirth, while pregnant women in the observation group received early perinatal health care and corresponding nutritional guidance on the basis of the above. The clinical efficacy of the two groups was compared, and the preventive value of early perinatal health care and nutritional guidance for GDM and premature birth was analyzed. 【Results】There was no significant difference in body mass index (BMI) before pregnancy between the two groups (P>0.05). The increase of BMI and body mass during pregnancy in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in the levels of fasting blood glucose (FPG), postprandial 2-hour blood glucose (2hPG) and plasma glycosylated glycoprotein (HbA1C) between the two groups before pregnancy (P>0.05); there was no significant change in the levels of FPG, 2hPG and HbA1C before pregnancy and during delivery in the observation group (P>0.05); the levels of FPG, 2hPG and HbA1C during delivery in the control group were significantly higher than those before pregnancy(P<0.05). The incidence of GDM and premature infants in the observation group were 3.45% and 3.45% respectively, which were significantly lower than those in the control group (19.61% and 21.57%, respectively). The difference between the two groups was statistically significant (P<0.05).【Conclusion】Early health care and nutritional guidance during perinatal period can effectively control BMI and blood sugar level of pregnant women, thus effectively prevent and reduce pregnancy complications such as GDM and adverse pregnancy outcomes such as premature infants. 2019 Vol. 36 (6): 1100-1102 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1103 Application of Phthalocyanine Green Fluorescence Staining Combined with Electrophysiological Monitoring in Glioblastoma Surgery in Brain Functional Area ZHANG Jue, SHU Guo-wei, GONG Li,et al DOI: 10.3969/j.issn.1671-7171.2019.06.021 【Objective】To investigate the application of phthalocyanine green fluorescence staining combined with electrophysiological monitoring in the treatment of glioma in brain functional area. 【Methods】A total of 105 patients with brain glandular gliomas admitted to our hospital from April 2012 to March 2018 were enrolled. Patients were divided into observation group (n=51) and control group (n=54) according to different detection methods.The patients in the observation group were treated with phthalocyanine green fluorescence staining combined with electrophysiological monitoring to guide glioma surgery. The patients in the control group were only treated with conventional craniotomy under electrophysiological monitoring. Observed the neurophysiological monitoring of the two groups, the surgical removal of the tumor and the recovery of the patient, the improvement of neurological function. The accuracy of the phthalocyanoma boundary was evaluated by analyzing the fluorescence of the indocyanine green. 【Results】Neuroelectrophysiological examination revealed that the tumor location of the patients was mainly in the linguistic area, limb movement area and sensory area. The total tumor resection rate was significantly higher in the observation group than in the control group (P<0.05). The recovery of muscle strength and KPS score in the observation group were significantly better than those in the control group (P<005). The recovery of neurological function in the exercise and sensory areas of the observation group was significantly better than that of the control group (P<0.05). The sensitivity of the observation group using phthalocyanine green fluorescent staining to evaluate the glioma cell border was 92.15% and the specificity was 90.19%.【Conclusion】The use of indocyanine green fluorescence staining combined with electrophysiological monitoring technology in patients with glioma of brain function area can guide the surgical removal of tumors, which can accurately identify tumor lesions and maximize the protection of patients' nerve function. 2019 Vol. 36 (6): 1103-1105 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1106 Clinical Analysis of 119 Cases of Pernicious Placenta Previa Caesarean Section SHI Xiao, WANG Mu-lan, LU Jun-li, et al DOI: 10.3969/j.issn.1671-7171.2019.06.022 【Objective】To investigate perioperative management of pernicious placenta previa. 【Methods】The clinical data of 119 cases of pernicious placenta previa from January 2012 to December 2018 were analyzed retrospectively. The patients were divided into two groups: the completed placenta previa group and the non-central type of pernicious placenta previa group. Placenta implantation rate, postpartum hemorrhage amount, perioperative blood transfusion volume, operation time and uterine resection rate were analyzed and compared between the two groups. 【Results】Placental implantation rate in the central group was 36.8% (35/95), significantly higher than that in the non-central group 8.3%(2/24, P<0.01). Postpartum hemorrhage amount: The median value of postpartum hemorrhage amount was 800(200~16000)mL in the central group, the mean was 1562±2253 ml, and that in the non-central group was 300(150~4000)mL and 637±1043 mL, respectively. That of the central group was significantly higher than of the non-central group (P<0.01). Perioperative blood transfusion: in the central group,the blood transfusion rate was 38.9%(37/95), while in the the non-central group, it was 8.3%(2/24). That of the central group was significantly higher than that of the non-central group. Operation time: patients in the central group had significantly longer operative time (118±76 min) than those in the non-central group (82.8±38 min) (P<0.05). There was no significant difference in uterine resection rate between the two groups. 【Conclusion】Central type of pernicious placenta previa is more liable to acquire placenta increta, and the risk of hemorrhage and blood transfusion is higher than the non-central group. 2019 Vol. 36 (6): 1106-1108 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1109 Effects of Low Molecular Weight Heparin Calcium on Cardiopulmonary Function, BNP Level and Inflammatory Status in COPD Patients with Pulmonary Heart Disease CHEN De-he, ZHANG Shi-guo, TANG Shan, et al DOI: 10.3969/j.issn.1671-7171.2019.06.023 【Objective】To investigate the effects of low molecular weight heparin calcium on cardiopulmonary function, BNP (brain natriuretic peptide) levels and inflammatory status in patients with COPD (chronic obstructive pulmonary disease) complicated with pulmonary heart disease. 【Methods】A total of 97 patients with COPD complicated with pulmonary heart disease who were treated in our hospital from March 2016 to March 2018 were randomly divided into the observation group (49 cases) and the control group (48 cases). The control group was treated with conventional treatment measures, and the observation group was treated with low molecular weight heparin on the basis of the control group. One week after treatment, the changes of coagulation function, lung function and blood gas index before and after treatment were observed. The BNP levels and inflammatory status of the two groups were analyzed before and after treatment. 【Results】The prothrombin time (PT), activated partial thromboplastin time (APTT), blood oxygen saturation (SpO2), arterial oxygen partial pressure (PaO2), one second forced expiratory volume (FEV1), the first-second forced expiratory volume occupancy capacity (FEV1/FVC) and one second rate (FEV1%) in the observation group were significantly higher than the control group. The D-dimer (DD) content and arterial blood carbon dioxide partial pressure were significantly lower than the control group; the difference between the two groups was statistically significant (P<0.05). Brain natriuretic peptide (BNP), interleukin 6 ( The levels of IL-6), tumor necrosis factor (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) in the observation group were significantly lower than the control group, and the difference was statistically significant (P<0.05). 【Conclusion】Low molecular weight heparin calcium in patients with COPD complicated with pulmonary heart disease can improve cardiopulmonary function and reduce BNP levels and inflammatory response in patients. 2019 Vol. 36 (6): 1109-1111 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1112 Effect of Intermedin on the Disease and Survival Status of Patients with Sepsis YANG Xiao-mei, HANG Min, XU Lei,et al DOI: 10.3969/j.issn.1671-7171.2019.06.024 【Objective】To investigate the effect of Intermedin (IMD) on the severity and survival of sepsis patients. 【Methods】 Ninety-four cases of sepsis were observed group, 86 cases of healthy people were control group. According to the severity of sepsis, the patients in the observation group were divided into 18 cases of systemic inflammatory response syndrome (SIRS), 34 cases of sepsis, 22 cases of severe sepsis and 20 cases of septic shock. The levels of IMD, serum adiponectin, tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were compared between the observation group and the control group. The acute physiology and chronic health score Ⅱ (APACHE Ⅱ) and the sequential organ failure assessment score (SOFA) were compared between the four groups. 【Results】The levels of IMD and serum adiponectin in the observation group were lower than those in the control group, and the levels of TNF-alpha and CRP were higher than those in the control group (P<0.05). The levels of IMD and serum adiponectin in the SIRS group, sepsis group, severe sepsis group and the septic shock group decreased in turn, the levels of TNF-alpha and CRP, APACHE Ⅱ and SOFA scores increased in turn, with significant differences among the four groups (P<0.05). 【Conclusion】 IMD is lower in sepsis patients, and the more serious the condition is, the lower the level of IMD is. The clinical condition of sepsis patients can be predicted by IMD. 2019 Vol. 36 (6): 1112-1113 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1114 Application of Controlled Hypotension, AHH and Recovery Autotransfusion in Neurosurgery Patients CHEN Yong, DENG Si-gao DOI: 10.3969/j.issn.1671-7171.2019.06.025 【Objective】To investigate the value of controlled hypotension, acute hypervolemic hemodilution (AHH) and retrieved autotransfusion in intracranial tumors surgery.【Methods】The clinical data of 82 patients with intracranial tumors admitted to our hospital from January 2016 to January 2018 were retrospectively analyzed. They were divided into observation group (controlled hypotension + AHH + recycled autotransfusion, n=43) and control group (controlled hypotension + AHH,n=39). The indexes of heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP) were observed immediately before AHH (T0), 30 minutes after AHH (T1), 60 minutes after AHH (T2) and at the end of operation (T3). 【Results】There was no significant difference in operation time and bleeding volume between the two groups (P>0.05); the proportion of non-transfused blood in the observation group was significantly higher than that in the control group (P<0.05). The MAP at T1 and T2 in the observation group and the control group was significantly higher than that at T0, and the CVP at T1 and T2 in the observation group was significantly higher than that in the control group (P<0.05). Postoperative fibrinogen (FIB) was lower in the two groups than that before operation, while prothrombin time (PT) and activated partial thrombin time (APTT) were significantly higher than those before operation (all P<0.05); there was no significant difference in FIB, PT and APTT between the observation group and the control group before and after operation (P>0.05). 【Conclusion】Controlled hypotension combined with AHH and recycled autologous blood transfusion have better application value in intracranial tumors surgery. It can reduce the situation of allogeneic blood transfusion and has little effect on hemodynamics and coagulation function. 2019 Vol. 36 (6): 1114-1116 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 1117 Establishment and Significance of Dose Diagnosis Reference Level of CT Scanning for Children under 15 Years Old in a Hospital CAO Zhen-wei, CHEN Dong-hui, ZHAI Zi-po,et al DOI: 10.3969/j.issn.1671-7171.2019.06.026 【Objective】To analyze the diagnostic reference level (DRL) of CT scan radiation dose for children under 15 years old in a hospital. 【Methods】 The related literatures were analyzed, and the DRL values of different parts of the skull, chest and abdomen of children under 15 years old in a hospital were recorded. 【Results】DRL analysis of children under 15 years old: The DRL of CTDIvol was 62.3 mGy, higher than the average DRL of Chinese children and adolescents, the DRL of dose-length product (DLP) was 714.4 mGy, lower than the average DLP of Chinese children and adolescents, and the DRL of CTDIvol of chest CT scan was 7.4 mGy, higher than that of me. The average DRL of Chinese children and adolescents is 4 mGy, and that of DLP is 227.4 mGy, which was higher than that of Chinese children and adolescents. The average DRL of CTDIvol on abdominal CT scan was 10.4 mGy, which was higher than that of Chinese children and adolescents. The DRL of DLP was 395.1 mGy, which was lower than that of Chinese children and adolescents. 【Conclusion】 The overall level of DRL in CT scans of the head, chest and abdomen of children under 15 years old is higher than the national average level, so it is necessary to find out the reasons and optimize the low dose in the actual scans. 2019 Vol. 36 (6): 1117-1119 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1120 Correlation Between Homocysteine Level and Carotid Intima-media Thickness in Patients with Type 2 Diabetes Mellitus Complicated with H-type Hypertension ZHU Ling-feng DOI: 10.3969/j.issn.1671-7171.2019.06.027 【Objective】To investigate the Correlation between homocysteine level and carotid intima-media thickness in patients with type 2 diabetes mellitus complicated with H-type hypertension. 【Methods】There were 82 patients with type 2 diabetes mellitus complicated with H-type hypertension treated in our hospital from January to February 2019 were enrolled. According to the value of carotid intima-media thickness (IMT), patients were divided into IMT normal group (28 cases), IMT thickening group (30 cases) and carotid plaque group (24 cases). Detecting and comparing the body mass index (BMI), blood pressure, blood glucose, blood lipids, serum Hcy, blood uric acid (UA), glycosylated hemoglobin (HbA1C), serum creatinine (Scr), IMT levels among the three groups. The relationship between serum Hcy, HbA1C, blood pressure and carotid IMT was analyzed. 【Results】There were significant differences in serum Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure between the three groups (P<0.05). The levels of serum Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure in the carotid plaque group were significantly higher than those in the IMT thickening group. The serum levels of Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure were significantly higher in the IMT thickening group than that in the normal IMT Group (P<0.05). Pearson correlation analysis showed that IMT was positively correlated with Hcy, HbA1C, systolic blood pressure and diastolic blood pressure (P<0.05). Using IMT as the test variable, Hcy, HbA1C, systolic blood pressure and diastolic blood pressure were used as independent variables to carry out two-class logistic regression analysis. The results showed that independent risk factors for IMT thickening were Hcy and systolic blood pressure. 【Conclusion】 The levels of serum Hcy, HbA1C and systolic blood pressure in patients with type 2 diabetes mellitus complicated with H-type hypertension are significantly correlated with IMT, which is an independent risk factor for IMT thickening. 2019 Vol. 36 (6): 1120-1122 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1123 Changes of microRNA133, HE4 and HO-1 Levels in Patients with Chronic Heart Failure and their Correlation with Cardiac Function ZHU Tong, LU Yan, LIU Chun-miao,et al DOI: 10.3969/j.issn.1671-7171.2019.06.028 【Objective】To investigate the correlation between serum microRNA133 (microRNA133), human epididymal protein 4 (HE4), heme oxygenase 1 (HO-1) and cardiac function in patients with chronic heart failure (CHF). 【Methods】The clinical data of 140 patients with CHF (observation group) admitted to our hospital from October 2016 to August 2017 were selected, and 70 healthy persons in the same period were selected as the control group. Serum levels of microRNA133, HE4 and HO-1 were detected and compared between the two groups, and the correlation between microRNA133, HE4 and HO-1 levels and LVEF in CHF patients was analyzed. 【Results】The serum HE4, HO-1 and microRNA-133 levels in the observation group were significantly higher than those in the control group (P<0.05). Serum HE4, HO-1 and microRNA-133 levels in CHF patients gradually increased with the increase of NYHA classification, and there were significant differences between groups (P<0.05). Serum HE4, HO-1 and microRNA133 levels in the observation group were negatively correlated with LVEF in CHF patients (rHE4=-0.611,rHO-1=-0.628,rmiRNA-133=-0.702 mean P<0.05).【Conclusion】The expression of microRNA-133, HE4 and HO-1 increases significantly in CHF patients, while the expression of microRNA-133, HE4 and HO-1 is negatively correlated with cardiac function in CHF patients. 2019 Vol. 36 (6): 1123-1124 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1125 Preventive Effect of Perioperative Hemoglobin and Prothrombin Time Monitoring on Reducing the Risk of Gastrointestinal Bleeding after Aortic Valve Replacement in Elderly Patients with Aortic Stenosis WANG Xiao-jun, TAO Yue DOI: 10.3969/j.issn.1671-7171.2019.06.029 【Objective】To analyze the preventive effect of hemoglobin and prothrombin time monitoring on the risk of gastrointestinal bleeding after aortic valve replacement in elderly patients with aortic stenosis. 【Methods】A total of 76 patients with aortic stenosis who underwent aortic valve replacement in our hospital from May 2016 to September 2017 were enrolled in our hospital. Blood samples were collected from all selected patients at 12h (T0), intraoperative (T1), and 12h (T2) after surgery. Hemoglobin was sampled from whole blood and immediately detected after collection. The detection method was high-performance liquid chromatography. Prothrombin time (PT) was measured using a Sysmex CA-7000 automated hemagglutination analyzer. Statistical analysis of the resulting data was performed using software SPSS 16.0. 【Results】 The hemoglobin levels in the case group at T1 and T2 were significantly lower than those in the control group (P<0.05). The hemoglobin level at T1 was significantly lower than that at T0 (P<0.05). The hemoglobin level at T2 was significantly higher than that at T1 (P<0.05). The prothrombin time in the case group at T1 and T2 was significantly longer than that in the control group (P<0.05). The prothrombin time at T1 was significantly longer than that at T0 (P<0.05). Prothrombin time was significantly shorter than T1 (P<0.05). Patients with upper gastrointestinal hemorrhage had hemoglobin and prothrombin measured in three different periods: 12h (T0), intraoperative (T1), and 12h (T2). There was a negative correlation (P<0.05). There was a negative correlation between hemoglobin and prothrombin levels during the intraoperative (T1) period in patients without upper gastrointestinal hemorrhage (P<0.05), 12 h before surgery (T0), and 12 h after surgery (P<0.05). 【Conclusion】Perioperative hemoglobin and prothrombin time monitoring have a certain preventive effect on reducing the risk of gastrointestinal bleeding after aortic valve replacement in elderly patients with aortic stenosis. At the same time, patients with a focus on hemoglobin reduction and prothrombin time should be paid attention to during the detection process. Once the relevant postoperative complications occur, the cause and symptomatic treatment should be promptly performed. 2019 Vol. 36 (6): 1125-1127 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1128 Analysis and significance of VEGF, Plasma Lipoprotein Associated Phospholipid A2 and Platelet Activation in Patients with Cerebral Infarction Complicated with Hyperlipidemia HAN Zheng-ran, YAN Feng-xia, WANG Shuang DOI: 10.3969/j.issn.1671-7171.2019.06.030 【Objective】To investigate the changes and significance of VEGF (vascular endothelial growth factor),Lp-PLA2(Plasma lipoprotein associated phospholipid A2)and platelet activation in patients with cerebral infarction complicated with hyperlipidemia. 【Methods】From January 2017 to September 2018, 56 patients with cerebral infarction complicated with hyperlipidemia were randomly selected as the observation group and 30 healthy persons as the control group. Serum VEGF and Lp-PLA2 levels were measured by ELISA and platelet activation function was measured by flow cytometry. At the same time, SPSS Pearson correlation analysis software was used to analyze the relationship between the level of VEGF,Lp-PLA2 and platelet activation function and cerebral infarction with hyperlipidemia.【Results】The levels of serum VEGF and plasma Lp-PLA2 in the observation group were significantly higher than those in the control group. CD63p, CD63 and PMA in the observation group were significantly higher than those in the control group (P<0.05). SPSS Pearson analysis showed that the levels of VEGF, Lp-PLA2 and platelet activation were positively related with severity of cerebral infarction complicated with hyperlipidemia. 【Conclusion】Platelet activation indices increase in patients with cerebral infarction and hyperlipidemia. Hypoxia and inflammatory infiltration are higher in brain tissue. It s necessary to inhibit platelet activation, improve hypoxia and control inflammatory reaction in cerebral infarction patients with hyperlipidemia. 2019 Vol. 36 (6): 1128-1129 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1130 Effect of Different Moisturizing Pretreatment Methods on the Cleaning Effect of External Instruments LI Hui, HAN Feng-li, CHEN Jing-jing DOI: 10.3969/j.issn.1671-7171.2019.06.031 【Objective】To explore the effect of different moisturizing pretreatment methods on the cleaning effect of external instruments. 【Methods】From January 2018 to June 2018, 86 foreign medical instruments were randomly selected from the disinfection and supply center of our hospital. They were randomly divided into group A and group B, each with 43 pieces. Group A was soaked with neutral multi enzyme cleaner, and B group was sprayed with gel moisturizer pretreatment. The cleaning effect was evaluated by comparing two groups of instruments routine test, occult blood residue detection, protein residue detection and ATP test results. 【Results】There was no significant difference in visual inspection and magnifying glass assistant examination between the two groups (P>0.05). The results of occult blood test, protein residue test and ATP fluorescence test in group B were better than those in group A, and the difference was statistically significant (P<0.05). 【Conclusion】The qualified rate of pretreatment for external equipment sprayed gel moisturizer was higher than that of pretreatment with soaking multi enzyme cleaner. 2019 Vol. 36 (6): 1130-1132 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )

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