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| Effect of Intermedin on the Disease and Survival Status of Patients with Sepsis |
| YANG Xiao-mei, HANG Min, XU Lei,et al |
| Emergency Department, Public-benefit Hospital, Pudong New Area, Shanghai, 200135 |
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Abstract 【Objective】To investigate the effect of Intermedin (IMD) on the severity and survival of sepsis patients. 【Methods】 Ninety-four cases of sepsis were observed group, 86 cases of healthy people were control group. According to the severity of sepsis, the patients in the observation group were divided into 18 cases of systemic inflammatory response syndrome (SIRS), 34 cases of sepsis, 22 cases of severe sepsis and 20 cases of septic shock. The levels of IMD, serum adiponectin, tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were compared between the observation group and the control group. The acute physiology and chronic health score Ⅱ (APACHE Ⅱ) and the sequential organ failure assessment score (SOFA) were compared between the four groups. 【Results】The levels of IMD and serum adiponectin in the observation group were lower than those in the control group, and the levels of TNF-alpha and CRP were higher than those in the control group (P<0.05). The levels of IMD and serum adiponectin in the SIRS group, sepsis group, severe sepsis group and the septic shock group decreased in turn, the levels of TNF-alpha and CRP, APACHE Ⅱ and SOFA scores increased in turn, with significant differences among the four groups (P<0.05). 【Conclusion】 IMD is lower in sepsis patients, and the more serious the condition is, the lower the level of IMD is. The clinical condition of sepsis patients can be predicted by IMD.
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Received: 29 May 2018
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2019, Vol. 36 
