Abstract【Objective】To investigate the effect of endoscopic injection of snake venom hemocoagulase on coagulation function and hemorheology in patients with upper gastrointestinal hemorrhage.【Methods】One hundred and thirty-six patients with upper gastrointestinal bleeding admitted to our hospital from July 2015 to June 2016 were selected as the study subjects, and randomly divided into observation group and control group with 68 cases in each group. The control group was sprayed and injected with 1:10000 epinephrine under endoscope. The observation group was injected with snake venom hemocoagulase on the basis of the control group. The hemostatic effect, coagulation function, Hemorheology and adverse reactions were compared between the two groups.【Result】The effective rate of the observation group was 95.59% higher than 85.29% of the control group, and the operative rate was 1.47% lower than 10.29% of the control group (all P<0.05); after 3 days of treatment, the prothrombin time (PT) and partial thromboplastin time (APTT) of the observation group were significantly shorter than those of the control group, and the platelet (PLT) and fibrinogen (FIB) were significantly higher than those of the control group (all P<0.05). High shear viscosity, whole blood low shear viscosity and hematocrit were significantly higher than those of the control group, and ESR was significantly lower than those of the control group (all P<0.05). Complications such as abdominal pain and fever in the two groups had no statistical significance (7.35% vs 4.41%, P<0.05).【Conclusion】Endoscopic injection of snake venom hemagglutinin can improve the hemostatic effect and reduce the operation rate in patients with upper gastrointestinal hemorrhage. The mechanism may be related to the improvement of blood coagulation function and the regulation of hemorheology.
HUANG Lin. Effect of Endoscopic Injection of Snake Venom Hemocoagulase on Coagulation Function and Hemorheology in Upper Gastrointestinal Hemorrhage[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(6): 1056-1058.
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2019, Vol. 36 
