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| Analysis and significance of VEGF, Plasma Lipoprotein Associated Phospholipid A2 and Platelet Activation in Patients with Cerebral Infarction Complicated with Hyperlipidemia |
| HAN Zheng-ran, YAN Feng-xia, WANG Shuang |
| Department of Neurology, Bozhou People Undefineds Hospital,An hui,236800 China |
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Abstract 【Objective】To investigate the changes and significance of VEGF (vascular endothelial growth factor),Lp-PLA2(Plasma lipoprotein associated phospholipid A2)and platelet activation in patients with cerebral infarction complicated with hyperlipidemia. 【Methods】From January 2017 to September 2018, 56 patients with cerebral infarction complicated with hyperlipidemia were randomly selected as the observation group and 30 healthy persons as the control group. Serum VEGF and Lp-PLA2 levels were measured by ELISA and platelet activation function was measured by flow cytometry. At the same time, SPSS Pearson correlation analysis software was used to analyze the relationship between the level of VEGF,Lp-PLA2 and platelet activation function and cerebral infarction with hyperlipidemia.【Results】The levels of serum VEGF and plasma Lp-PLA2 in the observation group were significantly higher than those in the control group. CD63p, CD63 and PMA in the observation group were significantly higher than those in the control group (P<0.05). SPSS Pearson analysis showed that the levels of VEGF, Lp-PLA2 and platelet activation were positively related with severity of cerebral infarction complicated with hyperlipidemia. 【Conclusion】Platelet activation indices increase in patients with cerebral infarction and hyperlipidemia. Hypoxia and inflammatory infiltration are higher in brain tissue. It s necessary to inhibit platelet activation, improve hypoxia and control inflammatory reaction in cerebral infarction patients with hyperlipidemia.
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Received: 29 November 2018
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2019, Vol. 36 
