乳腺癌组织中长非编码RNA SNHG16和SNHG19表达及其与病理特征、预后的关系

doi:10.3969/j.issn.1671-7171.2025.12.007

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摘要 【目的】探讨乳腺癌组织中长非编码RNA(LncRNA)SNHG16和SNHG19的表达水平及其与病理特征、预后的关系。【方法】检测98例乳腺癌患者的乳腺癌组织和癌旁正常组织中LncRNA SNHG16和SNHG19的表达水平,分析其与乳腺癌患者的病理特征和预后的关系。【结果】乳腺癌组织中LncRNA SNHG16和SNHG19的表达水平显著高于相邻正常组织(均P<0.05)。LncRNA SNHG16和SNHG19高表达组患者3年存活率均显著低于低表达组(P<0.05)。LncRNA SNHG16和SNHG19的表达与患者年龄、雌激素受体(ER)、孕激素受体 (PR)及淋巴结转移显著相关(均P<0.05),且LncRNA SNHG19的表达与TNM分期亦显著相关(均P<0.05)。患者较大年龄、ER阴性、PR阴性、TNM分期Ⅲ~Ⅳ期、淋巴结发生转移、LncRNA SNHG16高表达和LncRNA SNHG19高表达均是影响患者预后的危险因素(均P<0.05)。【结论】LncRNA SNHG16和SNHG19可能是乳腺癌预后不良的重要生物标志物,其可为乳腺癌的诊断、预后评估和治疗提供参考。

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	刘素娟
	周小芬
	王大鹏

关键词 ：乳腺肿瘤, 病理学, 免疫组织化学, RNA,长链非编码, 预后

Abstract：【Objective】 To investigate the correlation between the expression levels of long non-coding RNA(LncRNA) SNHG16 and SNHG19 in breast cancer tissues and the pathological characteristics as well as prognosis of patients.【Methods】 The expression levels of LncRNA SNHG16 and SNHG19 were detected in breast cancer tissues and adjacent normal tissues from 98 patients with breast cancer. Their associations with pathological features and prognosis were analyzed.【Results】 The expression levels of LncRNA SNHG16 and SNHG19 in breast cancer tissues were significantly higher than those in adjacent normal tissues (both P<0.05). Patients with high expression levels of LncRNA SNHG16 and SNHG19 had significantly lower 3-year survival rates than those with low expression (both P<0.05). The expression levels of LncRNA SNHG16 and SNHG19 were significantly correlated with patient age, estrogen receptor (ER) status, progesterone receptor (PR) status, and lymph node metastasis (all P<0.05). Additionally,LncRNA SNHG19 expression was significantly associated with TNM staging (P<0.05). Advanced age, ER negativity, PR negativity, TNM stage Ⅲ-Ⅳ, lymph node metastasis, high LncRNA SNHG16 expression, and high LncRNA SNHG19 expression were all risk factors affecting patient prognosis (all P<0.05).【Conclusion】 LncRNA SNHG16 and SNHG19 may act as important biomarkers for poor prognosis in breast cancer. They can provide references for diagnosis, prognostic evaluation, and treatment of breast cancer.

Key words： Breast Neoplasms Pathology Immunohistochemistry RNA, Long Noncoding Prognosis

收稿日期: 2025-06-27

中图分类号:

R737.9

引用本文:

刘素娟, 周小芬, 王大鹏. 乳腺癌组织中长非编码RNA SNHG16和SNHG19表达及其与病理特征、预后的关系[J]. 医学临床研究, 2025, 42(12): 2039-2041.
LIU Sujuan, ZHOU Xiaofen, WANG Dapeng. Relationship of the Expression of Long Non-Coding RNAs SNHG16 and SNHG19 in Breast Cancer Tissues with Pathological Features and Prognosis. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2039-2041.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.12.007 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I12/2039

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