Effect of Sevelamer Combined with Hemoperfusion Therapy on Itching Severity and Calcium-phosphorus Metabolism Indicators in Patients with Uremic Skin Itching
QI Shiping, XIONG Meizhen
Department of Nephrology,Fengcheng People's Hospital of Jiangxi Province, Fengcheng Jiangxi 331100
Abstract：【Objective】To explore the effect of sevelamer combined with hemoperfusion therapy on itching severity and calcium-phosphorus metabolism in patients with uremic skin itching.【Methods】A total of 76 patients with uremic skin itching admitted to the hospital from July 2022 to February 2024 were randomly divided into two groups using a random number table. The control group (n=38 cases) received blood perfusion therapy, while the observation group (n=38 cases) received sevelamer in addition to hemoperfusion of the control group. The itch severity score, inflammatory factors, calcium and phosphorus metabolism indicator, and quality of life were compared between two groups.【Results】After treatment, the sleep score, symptom and sign score, social psychological score, high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), interleukin-6 (IL-6), blood phosphorus, blood calcium, and total parathyroid hormone (iPTH) levels in the observation group were all lower than those in the control group (P<0.05). The World Health Organization Quality of Life Inventory (WHOQOL-BREF) scores were higher than those in the control group, with significantly statistical differences (P<0.05).【Conclusion】The application of sevelamer combined with blood perfusion therapy has significant therapeutic effects, which can alleviate itching symptoms, reduce inflammatory reactions, improve calcium and phosphorus metabolism indicators, and enhance quality of life.
2024, Vol. 41 
