Abstract：【Objective】To explore the effect of sevelamer carbonate on the transforming growth factor β1 (TGF-β1) / Smad pathway in elderly patients with end-stage renal disease (ESRD) complicated with hyperphosphatemia. 【Methods】Eighty-two elderly patients with ESRD and hyperphosphatemia were randomly divided into two groups,with 41 cases in each group. The control group was treated with calcium carbonate,while the observation group was treated with sevelamer carbonate. The levels of intact parathyroid hormone (iPTH),serum calcium ,serum phosphorus,lipid [total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)],renal function [serum creatinine (Scr),blood urea nitrogen (BUN)] and TGF-β1,Smad,and the occurrence rate of adverse reactions were compared between the two groups before and after treatment. 【Results】After treatment,the levels of serum calcium ,serum phosphorus,TG,TC,LDL-C,Scr,and BUN in both groups were lower than those before treatment (P<0.05),and these indicators in the observation group were lower than those in the control group (P<0.05). There were no significant differences in the levels of iPTH,HDL-C before and after treatment between the two groups (P>0.05). The levels of TGF-β1 were lower and the levels of Smad 7 were higher after treatment in both groups (P<0.05). The level of TGF-β1 in the observation group was lower than that in the control group,and the level of Smad 7 was higher than that in the control group (P<0.05). There was no significant difference in the occurrence rate of adverse reactions between the two groups (P>0.05). 【Conclusion】Sevelamer carbonate has a significant therapeutic effect on elderly patients with ESRD complicated with hyperphosphatemia. It can inhibit the expression of the TGF-β1/Smad signaling pathway,reduce the levels of blood calcium,phosphorus,and lipids,and is safe for medication use,hence it is worth promoting.
崔莹雪, 陈博婷, 张盼. 碳酸司维拉姆对老年终末期肾病合并高磷酸血症患者TGF-β1/Smad通路的影响[J]. 医学临床研究, 2023, 40(8): 1200-1203.
CUI Ying-xue, CHEN Bo-ting, ZHANG Pan. Effect of Sevelamer Carbonate on TGF-β1/Smad Pathway in Elderly Patients with End-stage Renal Disease and Hyperphosphatemia. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1200-1203.
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2023, Vol. 40 
