Effects of Sevilamer Carbonate on HO-1、iPTH、FGF-23 and Calcium and Phosphorus Metabolism in Patients with Chronic Renal Failure Complicated with Hyperphosphatemia
WANG Hui, LIU Fang, CHEN Cheng
Department of Blood Purification, Wuhan Red Cross Hospital, Wuhan Hubei 430000
Abstract：【Objective】To investigate the effects of sevilamer carbonate on heme oxidase-1(HO-1), fibroblast growth factor 23(FGF-23), whole-segment parathyroid hormone (iPTH) and calcium and phosphorus metabolism in patients with chronic renal failure (CRF) complicated with hyperphosphatemia.【Methods】From July 2015 to January 2017, 70 patients with CRF complicated with hyperphosphatemia in our hospital were selected and divided into control group and observation group according to different treatment methods. The control group was treated with conventional hemodialysis, while the observation group was treated with sevilamer carbonate on the basis of the control group. The levels of HO-1, iPTH, FGF-23, calcium and phosphorus metabolism and clinical efficacy of the two groups before and after treatment were compared.【Results】The total effective rate of the observation group was 91.42%, which was significantly higher than 68.57% of the control group (P<0.05). There was no significant difference in the levels of calcium, phosphorus, HO-1, iPTH and FGF-23 between the two groups before treatment (P>0.05); after treatment, the levels of phosphorus, HO-1, iPTH and FGF-23 in the observation group were significantly lower than those in the control group, and the calcium level was significantly higher than that in the control group, with statistical significance (P<0.05). The incidence of complications in the observation group was 11.43%, which was significantly higher than that in the control group (20.00%), and the difference was not statistically significant (P>0.05) 【Conclusion】Sevilamer carbonate combined with hemodialysis in the treatment of CRF patients with hyperphosphatemia can effectively reduce the levels of HO-1, iPTH and FGF-23, regulate the metabolism of calcium and phosphorus, and have low complications, which is worthy of clinical application.
王辉, 刘芳, 陈程. 碳酸司维拉姆对慢性肾衰竭合并高磷血症患者HO-1、iPTH、 FGF-23水平和钙磷代谢水平的影响[J]. 医学临床研究, 2020, 37(6): 854-856.
WANG Hui, LIU Fang, CHEN Cheng. Effects of Sevilamer Carbonate on HO-1、iPTH、FGF-23 and Calcium and Phosphorus Metabolism in Patients with Chronic Renal Failure Complicated with Hyperphosphatemia. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 854-856.
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2020, Vol. 37 
