miRNA-208b预测AMI后左心室重构的临床价值

doi:10.3969/j.issn.1671-7171.2024.04.021

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摘要【目的】探讨miRNA-208b(miR-208b)预测急性心肌梗死(AMI)后左心室重构的临床价值。【方法】选择2018年11月2020年9月本院收治的167例AMI患者,根据患者左心室是否出现重构将其分为重构组(n=62)和非重构组(n=105)。分析两组患者临床指标及miR-208b表达情况,分析miR-208b与左心室重构的相关性,采用受试者工作特征(ROC)曲线分析miR-208b评估AMI患者左心室重构的价值。【结果】重构组患者最终左室舒张末期容积(LVEDV)、左室舒张末期容积增加值(△LVEDV)、低密度脂蛋白胆固醇(LDL-C)、肌钙蛋白I(cTnI)及脑利钠肽(BNP)水平高于非重构组,miR-208b表达水平低于非重构组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,miR-208b与BNP及最终LVEDV呈负相关(P<0.05),与cTnI呈正相关(P<0.05)。ROC曲线分析显示,miR-208b预测AMI后左心室重构的价值较高,其曲线下面积(AUC)(95%CI)为0.80(0.73~0.87),其最佳诊断界值为3.17。二元Logistic回归分析显示,miR-208b、cTnI、LVEDV及BNP与左心室重构密切相关(P<0.05)。【结论】miR-208b是潜在的诊断AMI后左心室重构的重要临床指标,临床医师可根据AMI患者miR-208b表达情况预估其发生左心室重构的风险。

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	牛洪梅

关键词 ：心肌梗死, 急性病, 微RNAs, 心室重构

Abstract：【Objective】To explore the clinical value of miRNA-208b (miR-208b) in predicting left ventricular remodeling after acute myocardial infarction (AMI). 【Methods】A total of 167 AMI patients admitted to our hospital from November 2018 to September 2020 were selected, and they were divided into a remodeling group (n=62) and a non remodeling group (n=105) based on whether there was left ventricular remodeling during follow-up. The clinical indicators and expression of miR-208b, as well as the correlation between miR-208b and left ventricular remodeling, were analyzed in two groups of patients. The receiver operating characteristic (ROC) curve analysis was used to evaluate the value of miR-208b in left ventricular remodeling in AMI patients. 【Results】The final left ventricular end diastolic volume (LVEDV), left ventricular end diastolic volume increase (LVEDV), low-density lipoprotein cholesterol (LDL-C), cardiac troponin I (cTnI), and brain natriuretic peptide (BNP) levels of patients in the reconstruction group were higher than those in the non reconstruction group, and the expression level of miR-208b was lower than that in the non reconstruction group, with statistical significance (P<0.05). Pearson correlation analysis showed that miR-208b was negatively correlated with BNP and final LVEDV (P<0.05), and positively correlated with cTnI (P<0.05). ROC curve analysis showed that miR-208b had a high value in predicting left ventricular remodeling after AMI, with an area under the curve (AUC) (95%CI) of 0.80(0.73-0.87) and an optimal diagnostic threshold of 3.17. Binary logistic regression analysis showed that miR-208b, cTnI, LVEDV, and BNP were closely related to left ventricular remodeling (P<0.05). 【Conclusion】miR-208b is a potential clinical indicator for diagnosing left ventricular remodeling after AMI, and clinical physicians can estimate the risk of left ventricular remodeling in AMI patients based on miR-208b expression.

Key words： Myocardial Infarction Acute Disease MicroRNAs Ventricular Remodeling

收稿日期: 2022-05-11

中图分类号:

R542.22

引用本文:

牛洪梅. miRNA-208b预测AMI后左心室重构的临床价值[J]. 医学临床研究, 2024, 41(4): 555-557.
NIU Hongmei. The Clinical Value of miRNA-208b in Predicting Left Ventricular Remodeling after AMI. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 555-557.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.04.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I4/555

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