冠心病患者血清perilipin-5、RBP-4、FGF-23水平变化及其与冠状动脉狭窄程度的相关性

doi:10.3969/j.issn.1671-7171.2024.07.015

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摘要【目的】探讨冠心病患者血清脂滴蛋白-5(perilipin-5)、视黄醇结合蛋白-4(RBP-4)、成纤维细胞生长因子-23(FGF-23)水平变化及其与冠状动脉狭窄程度的相关性。【方法】选取2020年5月至2023年1月两院收治的142例冠心病患者(观察组),另选取100例同期体检的健康志愿者作为对照组。比较两组血清perilipin-5、RBP-4、FGF-23水平,比较不同冠心病类型、病变支数、狭窄程度患者血清perilipin-5、RBP-4、FGF-23水平,分析血清perilipin-5、RBP-4、FGF-23与病变支数、狭窄程度的相关性及对狭窄程度的诊断价值。【结果】观察组血清RBP-4、FGF-23水平高于对照组,血清perilipin-5水平低于对照组,差异有统计学意义(P<0.05)。稳定性心绞痛患者血清perilipin-5水平高于不稳定型心绞痛、急性心肌梗死患者,血清RBP-4、FGF-23水平低于不稳定型心绞痛、急性心肌梗死患者,差异有统计学意义(P<0.05)。轻度狭窄患者血清perilipin-5水平高于中度狭窄、重度狭窄患者,血清RBP-4、FGF-23水平低于中度狭窄、重度狭窄患者,差异有统计学意义(P<0.05)。单支病变患者血清perilipin-5水平高于双支病变、多支病变患者,血清RBP-4、FGF-23水平低于双支病变、多支病变患者,差异有统计学意义(P<0.05)。Spearman相关性分析,血清perilipin-5与病变支数、狭窄程度呈负相关,RBP-4、FGF-23与病变支数、狭窄程度呈正相关。受试者工作特征曲线分析显示,血清perilipin-5、RBP-4、FGF-23联合诊断冠心病狭窄程度的AUC为0.819,优于各单一指标诊断(P<0.05)。【结论】血清perilipin-5、RBP-4、FGF-23水平变化与冠心病患者病情显著相关,三者联合诊断有助于实现疾病危险分层。

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	刘金金
	郝亚杰
	付振强

关键词 ：冠心病, 冠状动脉狭窄, 脂蛋白类/血液, 视黄醇结合蛋白质类/血液, 成纤维细胞生长因子/血液

Abstract：【Objective】To investigate the changes in serum levels of perilipin-5, retinol binding protein-4 (RBP-4), and fibroblast growth factor-23 (FGF-23) in patients with coronary heart disease and their correlation with the degree of coronary artery stenosis. 【Methods】A total of 142 patients with coronary heart disease admitted to two hospitals from May 2020 to January 2023 (observation group) were selected, and 100 healthy volunteers who underwent physical examinations during the same period were selected as the control group. We compared the changes in serum levels of perilipin-5, RBP-4, and FGF-23 between two groups, and compared the levels of perilipin-5, RBP-4, and FGF-23 in patients with different types of coronary heart disease, number of lesion branches, and degree of stenosis. We analyzed the correlation between serum levels of perilipin-5, RBP-4, and FGF-23 and the number of lesion branches and degree of stenosis, as well as their diagnostic value for the degree of stenosis. 【Results】The serum levels of RBP-4 and FGF-23 in the observation group were higher than those in the control group, and the serum level of perilipin-5 was lower than that in the control group, with statistical significance (P<0.05). The serum levels of perilipin-5 in patients with stable angina are higher than those in patients with unstable angina and acute myocardial infarction, while the serum levels of RBP-4 and FGF-23 are lower than those in patients with unstable angina and acute myocardial infarction, and the differences are statistically significant (P<0.05). The serum levels of perilipin-5 in patients with mild stenosis were higher than those in patients with moderate and severe stenosis, while the serum levels of RBP-4 and FGF-23 were lower than those in patients with moderate and severe stenosis, and the differences were statistically significant (P<0.05). The serum level of perilipin-5 in patients with single vessel disease is higher than that in patients with double vessel disease and multi vessel disease, while the serum levels of RBP-4 and FGF-23 are lower than those in patients with double vessel disease and multi vessel disease, and the differences are statistically significant (P<0.05). Spearman correlation analysis showed that serum perilipin-5 is negatively correlated with the number and degree of stenosis of the lesion, while RBP-4 and FGF-23 are positively correlated with the number and degree of stenosis of the lesion. The analysis of the working characteristic curve of the subjects showed that the AUC of the combined diagnosis of perilipin-5, RBP-4, and FGF-23 for the degree of coronary heart disease stenosis was 0.819, which was better than the diagnosis of each single indicator (P<0.05). 【Conclusion】The changes in serum levels of perilipin-5, RBP-4, and FGF-23 are significantly correlated with the condition of coronary heart disease patients. The combined diagnosis of the three can help achieve disease risk stratification.

Key words： Coronary Disease Coronary Stenosis Lipoproteins/BL Retinol-Binding Proteins/BL Fibroblast Growth Factors/BL

收稿日期: 2023-09-18

中图分类号:

R541.4

引用本文:

刘金金, 郝亚杰, 付振强. 冠心病患者血清perilipin-5、RBP-4、FGF-23水平变化及其与冠状动脉狭窄程度的相关性[J]. 医学临床研究, 2024, 41(7): 1013-1016.
LIU Jinjin, HAO Yajie, FU Zhenqiang. Changes in Serum Levels of Perilipin-5, RBP-4, FGF-23 in Patients with Coronary Heart Disease and their Correlation with the Degree of Coronary Artery Stenosis. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1013-1016.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.07.015 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I7/1013

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