The Correlation between Coronary Artery Calcium Score and Short-Term Prognosis after Coronary Artery Disease Interventional Surgery
ZHANG Hongwei, LI Xinguo
Department of Geriatric Cardiovascular Medical,North Campus,Xi'an International Medical Center/Yan'an University School of Medicine,Xi'an Shaanxi 710119
Abstract：【Objective】 To explore the correlation between Coronary Artery Calcium Score (CCS) and the short-term prognosis of patients with Coronary Artery Disease (CAD) after interventional surgery. 【Methods】 A total of 120 patients who underwent coronary artery interventional treatment and coronary artery CT angiography (CTA) were included in the study. CCS was calculated for each patient. Patients were followed up for 6 months outside the hospital to record the occurrence of major adverse cardiac events (MACE) and the survival time without events. Based on those information, patients were divided into two groups: the poor prognosis group (n=27) and the good prognosis group (n=93). The relationship and predictive value of CCS in patients with their prognosis were analyzed. 【Results】 The age, CCS, serum creatinine (Scr), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). The time without MACE and Left Ventricular Ejection Fraction (LVEF) were significantly lower in the poor prognosis group compared to the good prognosis group (P<0.05).CCS showed a positive correlation with age (r=0.518, P<0.05) and Scr (r=0.407, P<0.05), and a negative correlation with LVEF (r=-0.215, P<0.05).The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for predicting MACE using CCS was 0.84(95%CI: 0.76-0.92).CCS, LVEF, and NT-proBNP were correlated with poor prognosis in patients, with odds ratios (OR) (95%CI) of 1.46 (0.61-3.49), 1.01 (0.98-1.05), and 1.24 (1.03-1.82), respectively. 【Conclusion】 CCS is an independent risk factor for poor short-term prognosis in patients undergoing interventional treatment for CAD and is a potential clinical indicator for assessing MACE.
[1] 李宁, 李海涛, 陈亮. 冠脉钙化程度对256层螺旋CT诊断冠脉狭窄病变的影响[J].实用医学杂志, 2014, 30(8): 1254-1257. [2] PEIX A,BATISTA E,CABRERA LO,et al. Gated-SPECT myocardial perfusion imaging and coronary calcium score for evaluation of patients with acute chest pain and a normal or nondiagnostic electrocardiogram[J].Coron Artery Dis,2012,23(7): 438-444. [3] SONG H G,KANG S J,AHN J M,et a1.Intravascular ultrasound assessment of optimal stent area to prevent in-stent restenosis after zotarolimus-, everolimus-, and sirolimus-eluting stent implantation[J].Catheter Card,2014,83(6):873-878. [4] 张茵,宋雷,宋莹,等. 冠状动脉病变钙化程度对介人治疗后冠心病患者远期预后的影响[J].中华心血管病杂志,2019,47(1):34-41. [5] 《中国心血管健康与疾病报告》编写组 .《中国心血管健康与疾病报告 2020》要点解读[J] 中国心血管杂志,2021,26(3):209-218. [6] 吕滨,庄囡,戴汝平,等. 冠状动脉钙化和CT 血管造影与常规危险因素诊断和预测冠心病的对比研究[J].中华心血管病杂志,2004,32(6):492-496. [7] AGATSTON A S,JANOWITZ W R,HILDNER F J,et al. Quantification of coronary artery calcium using ultrafast computed tomography[J].J Am Coll Cardiol,1990,15(4):827-832. [8] 张剑,韩雅玲,荆全民,等. 冠状动脉钙化积分与冠心病危险因素的相关性[J].中国介入心脏病学杂志,2011,19(6):318-321. [9] 何赟,丁凯,许建兴.CTA对冠脉狭窄的定量分析及诊断冠脉病变的应用价值[J].医学临床研究,2021,38(1):154-156. [10] 黄震,洪新华,印春涛.64排螺旋CT对不同严重程度冠状动脉钙化病变所致狭窄的诊断准确性及其临床价值[J].医学临床研究,2019,36(11):2201-2203. [11] GÉNÉREUX P,MADHAVAN M V,MINTZ G S,et al.Ischemic outcomes after coronary intervention of calcified vessels in acute coronary syndromes. Pooled analysis from the HORIZONS-AMI and ACUITY TRIALS[J].J Am Coll Cardiol,2014,63(18):1845-1854. [12] 何榕,韩江莉,许佳文,等. 钙化积分对冠状动脉介入治疗的稳定性冠心病患者的预测价值[J].中国介入心脏病学杂志,2011,19(1):2-6. [13] 朱新林,杨德辉,谭兵,等.硝酸甘油联合盐酸替罗非班治疗经皮冠状动脉介入术发生无复流现象时的临床疗效研究[J].中国现代手术学杂志,2016,16(2):119-121.
2024, Vol. 41 
