术前血清Lp-PLA2与NLRP3水平对IABP辅助PCI治疗的高危冠心病患者发生MACE的预测价值

doi:10.3969/j.issn.1671-7171.2024.05.016

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摘要【目的】探讨术前血清脂蛋白相关磷脂酶A2(Lp-PLA2)与核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)水平对主动脉内球囊反搏(IABP)辅助经皮冠状动脉介入治疗(PCI)高危冠心病患者发生心血管不良事件(MACE)的预测价值。【方法】选取本院收治的120例高危冠心病患者,所有患者均行IABP辅助PCI治疗。统计术后6个月内MACE发生情况,分为非MACE组和MACE组,比较两组术前血清Lp-PLA2、NLRP3水平,分析术前血清Lp-PLA2、NLRP3水平与冠脉狭窄程度的相关性,采用受试者工作特征(ROC)曲线分析术前血清Lp-PLA2、NLRP3水平预测术后发生MACE的价值。【结果】120例IABP辅助PCI术后高危冠心病患者MACE发生率为34.17%(41/120);MACE组术前血清Lp-PLA2、NLRP3水平均高于非MACE组(P<0.05)。Spearman相关性分析显示,术前血清Lp-PLA2、NLRP3水平与冠脉狭窄程度呈正相关(r_s=0.750、0.815,均P<0.05)。重度患者术前血清Lp-PLA2、NLRP3水平高于中度、轻度患者,中度患者高于轻度患者(P<0.05)。ROC曲线分析显示,术前血清Lp-PLA2、NLRP3水平单独预测的曲线下面积分别为0.770、0.844,二者联合预测AUC为0.909(P<0.05)。【结论】术前血清Lp-PLA2、NLRP3水平与高危冠心病患者冠脉狭窄程度呈正相关,二者联合检测可为临床预测高危冠心病患者IABP辅助PCI手术治疗后发生MACE提供一定参考依据。

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	王涛
	邹永辉
	杨蕾

关键词 ：冠心病, 1-烷基-2-乙酰甘油磷酸胆碱酯酶/血液, NLR家族,热蛋白结构域包含蛋白3/血液, 经皮冠状动脉介入治疗

Abstract：【Objective】To explore the predictive value of preoperative serum lipoprotein associated phospholipase A2 (Lp-PLA2) and nucleotide binding oligomeric domain like receptor protein 3 (NLRP3) levels for cardiovascular adverse events (MACE) in high-risk coronary heart disease patients undergoing intra-aortic balloon counterpulsation (IABP) assisted percutaneous coronary intervention (PCI).【Methods】A total of 120 high-risk coronary heart disease patients admitted to our hospital were selected and all underwent IABP assisted PCI treatment. The incidence of MACE within 6 months after surgery was statistically analyzed and divided into the non MACE group and the MACE group. The preoperative serum Lp-PLA2 levels were compared between the two groups NLRP3 level. The correlation between preoperative serum Lp-PLA2 and NLRP3 levels and the degree of coronary stenosis were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the value of preoperative serum Lp-PLA2 and NLRP3 level in predicting postoperative MACE.【Results】The incidence of MACE in 120 high-risk coronary heart disease patients after IABP assisted PCI was 34.17% (41/120); Preoperative serum Lp-PLA2 in the MACE group The levels of NLRP3 were higher than those in the non MACE group (P<0.05). Spearman correlation analysis showed that preoperative serum Lp-PLA2 The level of NLRP3 was positively correlated with the degree of coronary stenosis (r_s=0.750, 0.815, all P<0.05). The level of preoperative serum Lp-PLA2 and NLRP3 in severe patients was higher those in moderate and mild patients, with moderate patients having higher levels than mild patients (P<0.05). ROC curve analysis showed that the area under the curve predicted by preoperative serum Lp-PLA2 and NLRP3 level alone was 0.770 and 0.844, respectively. The joint prediction of AUC by the two was 0.909 (P<0.05).【Conclusion】The level of Preoperative serum Lp-PLA2 and NLRP3 was positively correlated with the degree of coronary artery stenosis in high-risk coronary heart disease patients. The combined detection of the two can provide a certain reference for clinical prediction of MACE in high-risk coronary heart disease patients after IABP assisted PCI surgery.

Key words： Coronary Disease 1-Alkyl-2-acetylglycerophosphocholine Esterase/BL NLR Family, Pyrin Domain-Containing 3 Protein/BL Percutaneous Coronary Intervention

收稿日期: 2023-06-30

中图分类号:

R541.4

引用本文:

王涛, 邹永辉, 杨蕾. 术前血清Lp-PLA2与NLRP3水平对IABP辅助PCI治疗的高危冠心病患者发生MACE的预测价值[J]. 医学临床研究, 2024, 41(5): 700-703.
WANG Tao, ZOU Yonghui, YANG Lei. The Predictive Value of Preoperative Serum Lp-PLA2 and NLRP3 Levels for MACE in High-Risk Coronary Heart Disease Patients Treated with IABP Assisted PCI. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 700-703.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.05.016 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I5/700

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