The Effect of the Combination of Alprazolam and Five Tone Therapy in the Treatment of Coronary Heart Disease with Insomnia and its Impact on Sleep Status and Heart Rate Variability in Patients
ZHENG Nannan, LI Jun, ZHANG Xiaodong
The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou Henan 450000
Abstract：【Objective】To explore the effect of alprazolam combined with five tone therapy in the treatment of coronary heart disease with insomnia and its impact on sleep status and heart rate variability in patients. 【Methods】A total of 98 patients with coronary heart disease and insomnia admitted to our hospital from April 2021 to December 2022 were selected. They were randomly divided into a control group and an observation group using a random number table method, with 49 cases in each group. Both groups were treated with basic coronary heart disease, the control group was treated with aprazolam, and the observation group was treated with aprazolam combined with five tone therapy. Two groups were compared in terms of efficacy, cardiovascular adverse events, disease-related scores before and after treatment [total score of traditional Chinese medicine syndrome, Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Hamilton Anxiety Scale (HANA)], heart rate variability indicators [mean square difference between adjacent normal RR intervals (RMSSD), 24-hour sinus rhythm RR interval standard deviation (SDNN), mean standard deviation between RR intervals (SDANN)], and laboratory indicators [leptin, melatonin (MT), angiotensin Ⅱ (Ang Ⅱ)]. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the total score of traditional Chinese medicine syndromes, ISI score, PSQI score, and HANA score in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the RMSSD, SDNN, and SDANN of the two groups were higher than before treatment, while the observation group was higher than the control group, with statistical significance (P<0.05). After treatment, the MT levels in both groups were higher than before treatment, while the levels of leptin and Ang Ⅱ were lower than before treatment. The difference between the observation group and the control group was statistically significant (P<0.05). The total incidence of cardiovascular adverse events in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】The combination of alprazolam and five tone therapy has a good therapeutic effect on patients with coronary heart disease and insomnia. It can effectively improve sleep status, increase heart rate variability, promote disease recovery, and reduce the incidence of cardiovascular and cerebrovascular adverse events.
郑楠楠, 李军, 张晓东. 阿普唑仑联合五音疗法治疗冠心病伴失眠的效果及对患者睡眠状态、心率变异性的影响[J]. 医学临床研究, 2024, 41(4): 583-586.
ZHENG Nannan, LI Jun, ZHANG Xiaodong. The Effect of the Combination of Alprazolam and Five Tone Therapy in the Treatment of Coronary Heart Disease with Insomnia and its Impact on Sleep Status and Heart Rate Variability in Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 583-586.
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2024, Vol. 41 
