Abstract：【Objective】To explore the more effective and safe way of quetiapine combined with midazolam in the treatment of Alzheimer's disease with sleep disturbance. 【Methods】A total of 127 patients with AD and sleep dysfunction were randomly divided into the observation group (n+65) and the control group (n=62). Patients in control group received quetiapine alone, while quetiapine plus midazolam were treated in the observation group. To Clinical efficacy and adverse effect between two groups were compared. 【Results】After 4 weeks of treatment, the total effective rate in the observation group was 96.92% (63/65), which was significantly higher than 80.65% (50/62) in the control group, and the difference was statistically significant (χ2=8.57, P<0.05). After 8 weeks of treatment, the total effective rate of the observation group was 100.00% (65/65), which was significantly higher than 87.10% (54/62) of the control group, and the difference was statistically significant (χ2=8.95, P<0.05). Before treatment, there were no statistically significant differences in the PSQI scores of sleep quality, time to fall asleep, daytime function, sleep disorder, sleep time, sleeping drugs, and total scores between the two groups of patients (all P>0.05). After 4 weeks and 8 weeks of treatment, the observation group's PSQI scores for sleep quality, time to fall asleep, daytime function, sleep time, sleeping drugs and other scores and total scores were significantly lower than those of the control group; And the differences were statistically significant (both P<0.05). However, there was no statistically significant difference in sleep disorder scores between the two groups (P>0.05). The total incidence of adverse reactions in the observation group was 3.07% (2/65), which was significantly lower than 14.52% (9/62) in the control group, and the difference was statistically significant (χ2=5.249, P=0.028).【Conclusion】Quetiapine combined with midazolam in the treatment of Alzheimer's disease with sleep disturbance was more effective and safer than singular quetiapine treatment and it was worth of application.
邱峥, 何必华, 林力. 喹硫平联合咪达唑仑治疗阿尔茨海默病合并睡眠功能障碍的临床疗效及安全性[J]. 医学临床研究, 2021, 38(10): 1490-1492.
QIU Zheng, HE Bi- hua, LIN Li. Efficacy and Safety of Quetiapine Joint Midazolam in the Treatment of Alzheimer's Disease with Sleep Disturbance. JOURNAL OF CLINICAL RESEARCH, 2021, 38(10): 1490-1492.
2021, Vol. 38 
