妊娠期糖尿病孕妇血清miR-16-5p、胎盘组织FGF21 mRNA的表达及意义

doi:10.3969/j.issn.1671-7171.2024.03.014

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摘要【目的】探讨妊娠期糖尿病(GDM)孕妇血清miR-16-5p、胎盘组织成纤维细胞生长因子21(FGF21) mRNA的表达及意义。【方法】选取2021年7月至2023年2月新乡医学院第三附属医院收治的102例GDM患者(观察组),另选取在新乡医学院第三附属医院定期产检的99例健康孕妇(对照组)。比较两组外周血miR-16-5p、胎盘组织FGF21表达水平,分析GDM发病的影响因素、GDM患者miR-16-5p与FGF21表达的相关性及miR-16-5p 对GDM发病的预测价值。【结果】观察组miR-16-5p相对表达量、FGF21 mRNA相对表达量高于对照组(P<0.05)。Logistic多因素回归分析显示:年龄、孕前体重指数、miR-16-5p相对表达量、FGF21 mRNA相对表达量是GDM发病的影响因素(P<0.05)。Pearson相关性分析显示:GDM患者miR-16-5p相对表达量与胎盘组织FGF21 mRNA相对表达量呈正相关(P<0.05)。受试者工作特征(ROC)曲线分析结果显示:外周血miR-16-5p相对表达量预测GDM发生的灵敏度为78.43%,特异度为83.84%,AUC为0.820。【结论】miR-16-5p、FGF21 mRNA表达与GDM发病有关,GDM患者外周血miR-16-5p与胎盘组织FGF21 mRNA表达呈正相关,miR-16-5p预测GDM发病的效能良好。

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	宋小玉
	姜清英

关键词 ：糖尿病,妊娠, 微RNAs/血液, 成纤维细胞生长因子

Abstract：【Objective】To investigate the expression and significance of serum miR-16-5p and placental fibroblast growth factor 21(FGF21) mRNA in pregnant women with gestational diabetes mellitus(GDM).【Methods】A total of 102 GDM patients admitted to the Third Affiliated Hospital of Xinxiang Medical College from July 2021 to February 2023 were selected as the observation group, and 99 healthy pregnant women admitted to the Third Affiliated Hospital of Xinxiang Medical College during the same period were selected as the control group. The clinical data such as the expression of miR-16-5p in peripheral blood and the expression of FGF21 in placental tissue of the two groups were collected. The factors affecting the incidence of GDM were analyzed. The correlation between miR-16-5p and FGF21 expression in GDM patients in the study group was analyzed. The value of miR-16-5p in predicting the occurrence of GDM was analyzed. 【Results】The relative expression of miR-16-5p and FGF21 mRNA in the observation group were higher than those in the control group(P<0.05). Logistic multivariate regression analysis showed that age, pre-pregnancy body mass index, relative expression of miR-16-5p and the relative expression of FGF21 mRNA were independent factors affecting the incidence of GDM(P<0.05). Pearson correlation analysis showed that the relative expression of miR-16-5p in GDM patients was positively correlated with the relative expression of FGF21 mRNA in placental tissue(P<0.05). The results of ROC curve analysis showed that the sensitivity of the relative expression of miR-16-5p in peripheral blood to predict the onset of GDM was 78.43%, the specificity was 83.84%, and the AUC was 0.820. 【Conclusion】The expressions of miR-16-5p and FGF21 mRNA are related to the pathogenesis of GDM. The expression of miR-16-5p in peripheral blood of GDM patients is positively correlated with the expression of FGF21 in placental tissue. The expression of miR-16-5p has a good effect on predicting the pathogenesis of GDM.

Key words： Diabetes, Gestational MicroRNAs/BL Fibroblast Growth Factors

收稿日期: 2023-03-02

中图分类号:

R714.256

引用本文:

宋小玉, 姜清英. 妊娠期糖尿病孕妇血清miR-16-5p、胎盘组织FGF21 mRNA的表达及意义[J]. 医学临床研究, 2024, 41(3): 371-374.
SONG Xiaoyu, JIANG Qingying. Expression and Significance of miR-16-5p and FGF21 mRNA in Patients with Gestational Diabetes Mellitus. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 371-374.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.03.014 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I3/371

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