摘要【目的】探讨化痰祛瘀方治疗痰浊瘀血型偏头痛急性发作的临床疗效。【方法】选择西安市碑林区中医医院收治的110例偏头痛患者,随机分为观察组和对照组,每组55例。观察组患者给予化痰祛瘀方治疗,对照组患者给予口服西比灵治疗。比较两组的临床疗效、中医证候积分、血液流变学指标、颅多普勒超声(TCD)检测结果及不良反应发生情况。【结果】观察组临床总有效率高于对照组(94.54% vs 81.82%, P<0.05);治疗后,观察组血浆比黏度、全血比黏度、红细胞压积水平均低于对照组(均P<0.05);治疗后,观察组中医证候积分低于对照组[(4.48±1.02)分 vs (6.76±1.20)分,P<0.05];两组患者治疗后大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)的平均血流速度较治疗前均降低(P<0.05),且观察组患者各指标水平低于对照组(均P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】痰浊瘀血型偏头痛患者用化痰祛瘀方治疗效果较好,可有效缓解偏头痛的临床症状,降低血液黏稠度,改善脑部血氧供应,且安全性高,值得临床推广。
Abstract：【Objective】To investigate the clinical effect of Chinese medicine Huatan Quyu decoction on acute attack of migraine with phlegm turbidity and blood stasis type. 【Methods】 A total of 110 patients with migraine admitted to Xi'an Beilin District Hospital of Traditional Chinese Medicine(TCM) were randomly divided into the observation group and the control group with 55 cases each. The patients in the observation group were treated with Huatan Quyu decoction,while the patients in the control group were treated with oral Sibirin. The clinical efficacy, TCM symptom score, hemorheology index, TCD test and the incidence of adverse reactions between the two groups were compared. 【Results】The total clinical effective rate in the observation group was 94.54%, which was higher than that of 81.82% in the control group(P<0.05). After treatment, the plasma specific viscosity, whole blood specific viscosity, hematocrit levels in the observation group were lower(P<0.05). The TCM syndrome score in the observation group after treatment was also lower than that in the control group after treatment(P<0.05). The average blood flow velocity of anterior cerebral artery(ACA), the middle cerebral artery(MCA), posterior cerebral artery(PCA) in the two groups were lower than that before treatment (P<0.05). While The levels of MCA, ACA and PCA in the observation group were lower than that in the control group (P<0.05). The incidence of adverse reactions in the two groups was not statistically different(P>0.05).【Conclusion】Huatan Quyu decoction has a good clinical effect on migraine patients of phlegm turbidity and blood stasis type. It can effectively relieve the clinical symptoms of migraine, reduce blood viscosity, improve brain blood oxygen supply, and has high safety, which is worthy of clinical promotion.
李茂林, 刘延菊. 化痰祛瘀方治疗痰浊瘀血型偏头痛急性发作的临床疗效[J]. 医学临床研究, 2024, 41(2): 237-239.
LI Maolin, LIU Yanju. Clinical Effect of Huatan Quyu Recipe on Acute Attack of Migraine with Type of Phlegm Turbidity and Blood Stasis. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 237-239.
2024, Vol. 41 
