外周血miR-200b-3p和miR-181b-5p联合多层螺旋CT灌注扫描对前列腺增生与前列腺癌的鉴别诊断价值

doi:10.3969/j.issn.1671-7171.2024.04.009

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摘要【目的】探讨多层螺旋CT(MSCT)灌注扫描联合血清微小RNA-200b-3p(miR-200b-3p)、微小RNA-181b-5p(miR-181b-5p)对前列腺增生(BPH)和前列腺癌的鉴别价值。【方法】选取2021年5月至2023年9月本院收治的249例前列腺病变患者,根据病理结果将其分为BPH组(n=144)和前列腺癌组(n=105)。采用Logistic回归分析血清miR-200b-3p、miR-181b-5p及MSCT灌注参数与前列腺癌的关系,绘制受试者工作特征曲线分析MSCT灌注参数联合血清miR-200b-3p、miR-181b-5p对前列腺癌的诊断价值。【结果】前列腺癌组患者血清miR-200b-3p水平高于BPH组,血清miR-181b-5p水平低于BPH组(P<0.05)。前列腺癌组患者相对血流量(rBF)、表面渗透性(PS)显著高于BPH组(P<0.05)。rBF、PS、miR-200b-3p、miR-181b-5p单独及联合诊断前列腺癌的曲线下面积分别为0.780、0.760、0.763、0.801、0.932。Logistic回归分析结果显示:miR-200b-3p>1.23、rBF>50.54 mL/(min?100 g)、PS>28.82 mL/(min?100 g)是影响前列腺癌发生的独立危险因素(P<0.05);miR-181b-5p＜0.90是影响前列腺癌发生的保护因素(P<0.05)。【结论】MSCT灌注成像参数联合血清miR-200b-3p、miR-181b-5p检测可为鉴别诊断BPH和前列腺癌提供可靠依据。

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	孟晟瑾

关键词 ：前列腺增生/诊断, 前列腺肿瘤/诊断, 体层摄影术, 螺旋计算机, 微RNAs

Abstract：【Objective】To explore the differential value of multi-slice spiral CT (MSCT) perfusion scan combined with serum microRNA-200b-3p (miR-200b-3p) and microRNA-181b-5p (miR-181b-5p) in benign prostatic hyperplasia (BPH) and prostate cancer. 【Methods】A total of 249 patients with prostate lesions admitted to our hospital from May 2021 to September 2023 were selected and divided into BPH group (n=144) and prostate cancer group (n=105) based on pathological results. Logistic regression analysis was used to investigate the relationship between serum miR-200b-3p, miR-181b-5p, and MSCT perfusion parameters with prostate cancer. A receiver operating characteristic curve was plotted to analyze the diagnostic value of MSCT perfusion parameters combined with serum miR-200b-3p and miR-181b-5p for prostate cancer. 【Results】The serum miR-200b-3p levels in the prostate cancer group were higher than those in the BPH group, while the serum miR-181b-5p levels were lower than those in the BPH group (P<0.05). The rBF and PS of patients in the prostate cancer group were significantly higher than those in the BPH group (P<0.05). The area under the curve of rBF, PS, miR-200b-3p, and miR-181b-5p for single and combined diagnosis of prostate cancer were 0.780, 0.760, 0.763, 0.801, and 0.932, respectively. The results of logistic regression analysis showed that rBF>50.54 mL/(min?100 g), PS>28.82 mL/(min?100 g),miR-200b-3p>1.23 were independent risk factors affecting the occurrence of prostate cancer (P<0.05); MiR-181b-5p<0.90 is a protective factor affecting the occurrence of prostate cancer (P<0.05). 【Conclusion】 The combination of MSCT perfusion imaging parameters and serum miR-200b-3p and miR-181b-5p detection can provide reliable basis for the differential diagnosis of BPH and prostate cancer.

Key words： Prostatic Hyperplasia/DI Prostatic Neoplasms/DI Tomography, Spiral Computed MicroRNAs

收稿日期: 2023-11-16

中图分类号:

R697.32

引用本文:

孟晟瑾. 外周血miR-200b-3p和miR-181b-5p联合多层螺旋CT灌注扫描对前列腺增生与前列腺癌的鉴别诊断价值[J]. 医学临床研究, 2024, 41(4): 511-514.
MENG Shengjin. Differential Diagnostic Value of Peripheral Blood miR-200b-3p and miR-181b-5p Combined with Multi-Slice Spiral CT Perfusion Scan for Benign Prostatic Hyperplasia and Prostate Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 511-514.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.04.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I4/511

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