The Value of Echocardiographic Parameters, Peripheral Blood T Lymphocyte Subsets, NF-κB, and CD64 Levels in Predicting the Prognosis of Neonatal Sepsis
WANG Fei
Children's Hospital Affiliated to Zhengzhou University/Children's Hospital of Henan Province Zhengzhou Children's Hospital,Zhengzhou Henan 450052
Abstract：【Objective】To explore the value of echocardiographic parameters, peripheral blood T lymphocyte subsets, nuclear factor-κB(NF-κB), and cluster differentiation antigen 64(CD64) levels in predicting the prognosis of neonatal sepsis. 【Methods】 A total of 95 neonatal sepsis patients admitted to our hospital from January 2020 to February 2023 were selected and divided into a survival group(n=80) and a death group(n=15) according to their prognosis. The echocardiographic parameters [left ventricular short axis shortening fraction(FS), ascending aorta diameter(AAO), left ventricular ejection fraction(LVEF)], myocardial injury markers [creatine kinase(CK), creatine kinase isoenzyme(CK-MB)], T lymphocyte subsets(CD3+, CD4+, CD8+), NF-κB, and CD64 levels were compared between the two groups. Logistic multivariable regression analysis was used to analyze the relevant factors affecting the poor prognosis of neonatal sepsis. The receiver operating characteristic(ROC) curve was used to analyze the clinical value of electrocardiogram and laboratory indicators in predicting the prognosis of neonatal sepsis. 【Results】 There was no significant difference in the levels of creatine kinase CK and CK-MB between the two groups(P>0.05). The FS, AAO, and LVEF in the survival group were higher than those in the death group, and the difference was statistically significant(P<0.05). There was no significant difference in the CD8+ level between the two groups(P>0.05). The CD3+ and CD4+ levels in the survival group were higher than those in the death group, while the NF-κB and CD64 levels were lower, and the difference was statistically significant(P<0.05). There was no significant difference in the NLR and CRP levels between the two groups(P>0.05). The WBC level in the survival group was lower than that in the death group, and the difference was statistically significant(P<0.05). Logistic multivariable regression analysis showed that FS, LVEF, and CD64 were related factors affecting the prognosis of neonatal sepsis(P<0.05). The area under the ROC curve for FS, LVEF, and CD64 combined to predict the prognosis of neonatal sepsis was 0.948, which was significantly higher than that of each individual indicator(0.827, 0.895, and 0.877, respectively)(P<0.05). 【Conclusion】The combined detection of FS, LVEF, and CD64 has good predictive value for the prognosis of neonatal sepsis. Clinicians can closely monitor these indicators to timely judge the prognosis of neonatal sepsis and take relevant intervention measures.
王菲. 超声心动图参数及外周血T淋巴细胞亚群、NF-κB、CD64水平预测新生儿败血症预后的价值[J]. 医学临床研究, 2024, 41(3): 340-343.
WANG Fei. The Value of Echocardiographic Parameters, Peripheral Blood T Lymphocyte Subsets, NF-κB, and CD64 Levels in Predicting the Prognosis of Neonatal Sepsis. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 340-343.
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2024, Vol. 41 
