腹腔镜下卵巢囊肿剔除术对患者卵巢功能、炎症因子及T淋巴细胞亚群水平的影响

doi:10.3969/j.issn.1671-7171.2024.02.027

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摘要【目的】探讨腹腔镜下卵巢囊肿剔除术对患者卵巢功能、炎症因子及T淋巴细胞亚群水平的影响。【方法】选取2019年1月至2023年1月本院妇科收治的76例卵巢囊肿患者,根据手术方法不同分为对照组和观察组,每组38例。对照组行开腹卵巢囊肿剔除术治疗,观察组行腹腔镜下卵巢囊肿剔除术治疗,比较两组手术前后卵巢功能[雌二醇(E₂)、促卵泡激素(FSH)、黄体生成素(LH)]、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及T淋巴细胞亚群水平(CD3⁺、CD4⁺ 及CD4⁺/CD8⁺)。【结果】两组术后3个月FSH、LH均升高,但观察组低于对照组(P<0.05);两组术后3个月E₂均降低,但观察组高于对照组(P<0.05)。观察组患者术后IL-6、TNF-α、CRP水平低于对照组,差异有统计学意义 ( P<0.05)。两组患者术前CD4⁺、CD4⁺/CD8⁺比较,差异无统计学意义( P>0.05);术后1 d,两组患者血清CD3⁺、CD4⁺、CD4⁺/CD8⁺均较术前明显降低,但观察组高于对照组,差异均有统计学意义(P<0.05);观察组患者术后3 d血清 CD3⁺、CD4⁺、CD4⁺/ CD8⁺恢复至术前水平。【结论】腹腔镜下卵巢囊肿剔除术可有效促进患者卵巢功能恢复,并减轻机体炎症反应,提高T淋巴细胞亚群水平,减轻对机体细胞免疫功能的抑制,有利于患者术后康复。

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	王敏
	李国玉
	王兰

关键词 ：卵巢囊肿/外科学, 腹腔镜检查, 卵巢功能试验, T淋巴细胞亚群

Abstract：【Objective】To explore the effects of laparoscopic ovarian cystectomy on ovarian function, inflammatory factors, and T lymphocyte subsets in patients. 【Methods】A total of 76 patients with ovarian cysts admitted to the gynecology department of our hospital from January 2019 to January 2023 were selected and divided into a control group and an observation group based on different surgical methods, with 38 cases in each group. The control group underwent open ovarian cystectomy, while the observation group underwent laparoscopic ovarian cystectomy. Ovarian function [estradiol (E₂), follicle stimulating hormone (FSH), luteinizing hormone (LH)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), C-reactive protein (CRP)], and T lymphocyte subsets (CD3⁺, CD4⁺, and CD4⁺/CD8⁺) before and after surgery were compared between the two groups. 【Results】FSH and LH increased in both groups 3 months after surgery, but the observation group was lower than the control group (P<0.05); E₂ levels decreased in both groups 3 months after surgery, but the observation group was higher than the control group (P<0.05). The postoperative levels of IL-6, TNF-α, and CRP in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in preoperative CD4⁺ and CD4⁺/CD8⁺ between the two groups of patients (P>0.05).On the 1st day after surgery, the serum CD3⁺, CD4⁺, CD4⁺/CD8⁺ levels in both groups of patients were significantly lower than before surgery, but the observation group was higher than the control group, and the differences were statistically significant (P<0.05).The serum CD3⁺, CD4⁺, CD4⁺/CD8⁺ levels in the observation group patients returned to preoperative levels 3 days after surgery. 【Conclusion】Laparoscopic ovarian cyst removal surgery can effectively promote the recovery of ovarian function in patients, reduce the body's inflammatory response, increase the level of T lymphocyte subsets, and alleviate the suppression of cellular immune function, which is beneficial for postoperative recovery of patients.

Key words： Ovarian Cysts/SU Laparoscopy Ovarian Function Tests T-Lymphocyte Subsets

收稿日期: 2023-06-26

中图分类号:

R711.75

引用本文:

王敏, 李国玉, 王兰. 腹腔镜下卵巢囊肿剔除术对患者卵巢功能、炎症因子及T淋巴细胞亚群水平的影响[J]. 医学临床研究, 2024, 41(2): 254-257.
WANG Min, LI Guoyu, WANG Lan. The Effects of Laparoscopic Ovarian Cystectomy on Ovarian Function, Inflammatory Factors and T Lymphocyte Subsets. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 254-257.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.02.027 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I2/254

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