复方甘草酸苷联合他克莫司治疗过敏性紫癜性肾炎患儿的临床效果

doi:10.3969/j.issn.1671-7171.2024.02.026

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摘要【目的】探讨复方甘草酸苷联合他克莫司治疗过敏性紫癜性肾炎患儿的临床效果。【方法】选择2020年1月至2023年1月本院收治的88例过敏性紫癜性肾炎患儿,采用随机数字表法将其分为观察组与对照组,每组44例。对照组采用复方甘草酸苷治疗,观察组采用复方甘草酸苷联合他克莫司治疗,两组治疗时间均为2个月。比较两组患儿肾功能指标[免疫球蛋白G(lgG)、免疫球蛋白A(lgA)]、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]及不良反应发生情况。【结果】治疗后,两组lgG、lgA水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);两组血清IL-6、TNF-α水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。观察组患者临床有效率高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。【结论】复方甘草酸苷联合他克莫司可改善过敏性紫癜性肾炎患儿肾功能,缓解炎症反应,临床治疗效果较好,且不良反应发生率低,值得推广与应用。

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	张琼
	周芳
	郭亚菊

关键词 ：紫癜,过敏性/并发症, 肾炎/并发症, 甘草酸/药理学, 他克莫司结合蛋白质类/药理学

Abstract：【Objective】To explore the clinical effect of compound glycyrrhizic acid glycoside combined with tacrolimus in the treatment of children with allergic purpura nephritis. 【Methods】A total of 88 children with allergic purpura nephritis admitted to our hospital from January 2020 to January 2023 were selected and randomly divided into an observation group and a control group using a random number table method, with 44 cases in each group. The control group was treated with compound glycyrrhizic acid glycoside, while the observation group was treated with compound glycyrrhizic acid glycoside combined with tacrolimus. The treatment time for both groups was 2 months. Two groups of children were compared in terms of renal function indicators [immunoglobulin G (lgG), immunoglobulin A (lgA)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α)], oxidative stress indicators [malondialdehyde (MDA), superoxide dismutase (SOD)], and incidence of adverse reactions. 【Results】After treatment, the levels of lgG and lgA in both groups were lower than before treatment, and the observation group was lower than the control group, with a statistically significant difference (P<0.05); The serum levels of IL-6 and TNF-α in the two groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). The clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】The combination of compound glycyrrhizic acid glycoside and tacrolimus can improve renal function and alleviate inflammatory reactions in children with allergic purpura nephritis. The clinical treatment effect is good, and the incidence of adverse reactions is low. It is worth promoting and applying.

Key words： Purpura, Schoenlein-Henoch/CO Nephritis/CO Glycyrrhizic Acid/PD Tacrolimus Binding Proteins/PD

收稿日期: 2023-06-19

中图分类号:

R726.923.4

通讯作者: *E-mail:15991667416@163.com

引用本文:

张琼, 周芳, 郭亚菊. 复方甘草酸苷联合他克莫司治疗过敏性紫癜性肾炎患儿的临床效果[J]. 医学临床研究, 2024, 41(2): 251-253.
ZHANG Qiong, ZHOU Fang, GUO Yaju. Clinical Efficacy of Compound Glycyrrhizic Acid Glycoside Combined with Tacrolimus in the Treatment of Children with Allergic Purpura Nephritis. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 251-253.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.02.026 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I2/251

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