Abstract：【Objective】To investigate the effect of scalp nerve block-assisted general anesthesia on stress response and vital signs in patients undergoing Intracranial space-occupying operation. 【Methods】 A total of 90 patients undergoing elective intracranial space-occupying operation in our hospital were randomly divided into two groups:the 45 patients in the control group underwent general anesthesia and the other 45 patients in the observation group underwent scalp nerve block-assisted general anesthesia. Vital signs such as diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR) and serum dopamine (DA), adrenaline (A), noradrenaline (NE) were compared between the two groups at different time points:before anesthesia induction (T0), upper head frame placement (T1), skin incision (T2), periosteal separation (T3), bone flap/craniectomy (T4), intraoperative (T5), skin suture (T6), extubation (T7). and other body stress factor levels and the usage of drug doses in the two groups was recorded. 【Results】There were no significant differences in DBP,SBP and HR between the two groups at T0, T4, and T5 (P>0.05); While the DBP, SBP, HR at T1, T6, and T7 in the observation group were lower those in the control group; the DBP of the observation group at T2 was lower than that of the control group, and HR at T3 in the observation group was lower than that in the control group (P<0.05). There were no significant differences between the two groups in terms of SBP and HR at T2 plus SBP and DBP at T3 (P>0.05). There were no significant differences in serum DA, A and NE levels between the two groups at T0 (P>0.05). The serum DA, A and NE levels of the observation group were lower than those of the control group at T1, T2, T3, T4, T5, T6 and T7; And the differences were statistically significant (P<0.05). The remifentanil doses in the observation group and the control group were (2.24±1.60) mg and (4.72±1.52) mg, respectively, with statistically significant difference between the two groups (P<0.05). There was no significant difference of the propofol usage between the two groups (P>0.05). 【Conclusion】Scalp nerve block-assisted general anesthesia can better maintain the stability of vital signs during Intracranial space-occupying operation, relieve the relieve body stress and reduce the usage of general analgesics.
2023, Vol. 40 
