Efficacy of Letrozole Combined with Recombinant Human Growth Hormone in the Treatment of Adolescent Short Stature Boys and Drug Effects on Physical Development and Bone Metabolism
Abstract：【Objective】To study the efficacy of letrozole combined with recombinant human growth hormone in treating boys with pubertal short stature and drug effects on physical development and bone metabolism.【Methods】One hundred and fifty boys with adolescent short stature disorder admitted to the hospital from January 2021 to January 2022 were divided into a control group and a combination group with 75 cases each by the random number table method. The control group was treated with recombinant human growth hormone and the combination group was treated with letrozole combined with recombinant human growth hormone. The physical development indexes [height,weight,growth velocity (GV),height standard deviation score (HtSDS)],serum bone metabolism indexes [osteocalcin (OC),bone alkaline phosphatase (BALP),pre-collagen type Ⅰ amino-terminal peptide (PINP),β-collagen degradation product (β-CTX)],serum appetite stimulating hormone (Ghrelin),serum insulin-like growth factor binding protein-3 (IGFBP-3) levels,core generalized children's quality of life scale (PedsQL) scores,and incidence of adverse reactions were compared between the two groups.【Results】The physical development indexes in the combined group were higher than those in the control group after 6 and 12 months of treatment (P<0.05). After 6 and 12 months of treatment,the improvement of serum bone metabolism indexes and levels of both serum Ghrelin and IGFBP-3 in the combined group were greater than those in the control group (P<0.05). The PedsQL score in the combined group was higher than that in the control group after 6 and 12 months of treatment (P<0.05 ). The overall incidence of adverse reactions in the combined group was 9.33% and overall incidence of adverse reactions was 6.67% in the control group,which was not statistically significant (P>0.05).【Conclusion】The combination of letrozole and recombinant human growth hormone is effective in treating male children with adolescent short stature disorder,and it can regulate the level of bone metabolic indexes and promote the growth and development of children with high safety.
符承丽, 牛宛柯. 来曲唑联合重组人生长激素治疗青春期身材矮小症男性患儿的疗效及对其体格发育、骨代谢的影响[J]. 医学临床研究, 2023, 40(9): 1389-1391.
FU Chengli, NIU Wanke. Efficacy of Letrozole Combined with Recombinant Human Growth Hormone in the Treatment of Adolescent Short Stature Boys and Drug Effects on Physical Development and Bone Metabolism. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1389-1391.
2023, Vol. 40 
