Abstract：【Objective】To investigate the correlation between bone metabolism indexes and estimated glomerular filtration rate (eGFR) in elderly patients with type 2 diabetic nephropathy. 【Methods】A total of 129 elderly patients with type 2 diabetic nephropathy admitted from May 2019 to October 2020 were selected as the observation group, and 125 patients with simple type 2 diabetes (T2DM) were selected as the control group. The general information, bone metabolism indexes and eGFR of the two groups of patients were recorded. Bone metabolism index ｛blood calcium (Ca), blood phosphorus (P), osteocalcin (OCN), 25 hydroxy vitamin D3[25(OH)D3], parathyroid hormone (PTH) and total type Ⅰ｝ procollagen amino terminal were compared between the two groups. The correlation of eGFR with bone metabolism index, parathyroid hormone (PTH) and propeptide (T-PINP) was analyzed. 【Results】There were no statistically significant differences in gender, age, body mass index (BMI), combined with hypertension, and combined with hyperlipidemia between the two groups (P>0.05). Compared with the control group, the observation group had a longer course of diabetes with higher level of fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), urine albumin, blood P, OCN, PTH, T-PINP and eGFR increased (P<0.05), while the blood Ca and 25(OH)D3 levels decreased in the observation group (all P<0.05). Compared to patients with renal function stage Ⅰ~Ⅱ, OCN, PTH and T-PINP in patients with stage Ⅲ~Ⅴ increased (all P<0.001), while their 25(OH)D3 and eGFR decreased (all P<0.05). OCN (r=-0.863, P=0.002), PTH (r=-0.754, P=0.013) and T-PINP (r= -0.728, P=0.018) were negatively correlated with eGFR(r=-0.863,P=0.002;r=-0.754,P=0.013;r=-0.728,P=0.018), while 25(OH)D3 was positively correlated with eGFR (r=0.802, P=0.005). 【Conclusion】There are abnormalities in bone metabolism and eGFR in elderly patients with type 2 diabetic nephropathy, and there is a correlation of eGFR with OCN, PTH, T-PINP and 25(OH)D3.
陈玉昌, 王重阳. 老年2型糖尿病性肾病患者骨代谢指标与肾小球滤过率的相关性分析[J]. 医学临床研究, 2021, 38(12): 1777-1779.
CHEN Yu-chang, WANG Chong-yang. Relationship between Bone Metabolism Indexes and Glomerular Filtration Rate in Elderly Patients with Type 2 Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2021, 38(12): 1777-1779.
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2021, Vol. 38 
