Abstract：【Objective】To investigate the clinical significance of bone metabolism biochemical indexes detection in high-risk elderly patients with osteoporosis (OP). 【Methods】Elderly patients with OP (group B,n=67), elderly patients with high-risk of OP (group A, n=75) and elderly patients without OP (control group, n=52) were selected as study subjects. Bone mineral density (BMD) of lumbar L2~4 and femoral neck was measured. Levels of bone metabolism indexes, including serum calcium (Ca), phosphorus (P), β-Crosslaps (β-CTX), N-terminal osteocalcin (N-MID), total collagen type I amino-terminal propeptide (PINP) and 25-hydroxy vitamin D [25-(OH) D3] were determined. 【Results】There were no significant differences in serum Ca and P between the three groups (P>0.05). P I NP and β-CTX in group B were higher than those in group A and the control group while N-MID and BMD of lumbar L2~4 and femoral neck were lower in group B than those in group A and the control group(P<0.05). There were no significant differences in other indexes (P>0.05). There was significant difference in PINP between group A and the control group (P<0.05). The 25-(OH) D3 in group B and group A were lower than that in control group (P<0.05), but there was no significant difference between group A and group B (P>0.05). 【Conclusion】Dynamic monitoring of changes of levels of PINP and 25-(OH) D3 can be used to screen elderly patients with high risk of OP.
2016, Vol. 33 
